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. 1990;30(Suppl 1):128S–130S. doi: 10.1111/j.1365-2125.1990.tb05483.x

Effect of hypo- and hyperthyroidism on binding of [3H]-nitrendipine to myocardial and brain membranes

Christoph Kosinski, Gerhard Gross, Gertraud Hanft
PMCID: PMC1368113  PMID: 2176516

Abstract

The density of calcium channel binding sites as determined by [3H]-nitrendipine binding was found to be decreased in hearts of hyperthyroid rats but hardly altered by hypothyroidism. In contrast, dihydropyridine binding sites in the cerebral cortex were unaffected by dysthyroid states. Myocardial [3H]-nitrendipine binding sites were also decreased after treatment of the animals with isoprenaline but not in spontaneously hypertensive rats. These findings suggest that myocardial hypertrophy is not necessarily accompanied by a loss of calcium channels and that thyroid hormone regulates the density of [3H]-nitrendipine binding sites in a tissue-specific manner.

Keywords: [3H]-nitrendipine binding, Ca++-channels, thyroid hormone, myocardial, hypertrophy, spontaneously hypertensive rats

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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