Abstract
1. The efficacy and safety of a novel percutaneous anaesthetic preparation based on amethocaine has been investigated in the paediatric clinical environment. 2. There were 1241 recorded applications on a named patient basis made to patients from infant to age 16 years. Of these, 88.7% had satisfactory anaesthesia to venepuncture challenge, rising to approximately 90% when the infant group was excluded. 3. A 30 min application time was found to be adequate for reliable topical anaesthesia. 4. There were no serious adverse reactions to the preparation. Of the total 6.9% recorded reactions, 6.3% were of a mild, transient erythema later identified as due to the vasodilator action of the drug. 5. A total of 123 patients received more than one application of the preparation. There was no evidence of sensitisation on subsequent exposure to the preparation. 6. The short application time required was found to be advantageous to ward and clinic routines.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLOM G. E. The reactions of hospitalized children to illness. Pediatrics. 1958 Sep;22(3):590–600. [PubMed] [Google Scholar]
- Clarke S., Radford M. Topical anaesthesia for venepuncture. Arch Dis Child. 1986 Nov;61(11):1132–1134. doi: 10.1136/adc.61.11.1132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ehrenström Reiz G. M., Reiz S. L. EMLA--a eutectic mixture of local anaesthetics for topical anaesthesia. Acta Anaesthesiol Scand. 1982 Dec;26(6):596–598. doi: 10.1111/j.1399-6576.1982.tb01822.x. [DOI] [PubMed] [Google Scholar]
- Hopkins C. S., Buckley C. J., Bush G. H. Pain-free injection in infants. Use of a lignocaine-prilocaine cream to prevent pain at intravenous induction of general anaesthesia in 1-5-year-old children. Anaesthesia. 1988 Mar;43(3):198–201. [PubMed] [Google Scholar]
- McCafferty D. F., Woolfson A. D., Boston V. In vivo assessment of percutaneous local anaesthetic preparations. Br J Anaesth. 1989 Jan;62(1):17–21. doi: 10.1093/bja/62.1.17. [DOI] [PubMed] [Google Scholar]
- McCafferty D. F., Woolfson A. D., McClelland K. H., Boston V. Comparative in vivo and in vitro assessment of the percutaneous absorption of local anaesthetics. Br J Anaesth. 1988 Jan;60(1):64–69. doi: 10.1093/bja/60.1.64. [DOI] [PubMed] [Google Scholar]
- Small J., Wallace R. G., Millar R., Woolfson A. D., McCafferty D. F. Pain-free cutting of split skin grafts by application of a percutaneous local anaesthetic cream. Br J Plast Surg. 1988 Sep;41(5):539–543. doi: 10.1016/0007-1226(88)90014-8. [DOI] [PubMed] [Google Scholar]
- Woolfson A. D., McCafferty D. F., McClelland K. H., Boston V. Concentration-response analysis of percutaneous local anaesthetic formulations. Br J Anaesth. 1988 Nov;61(5):589–592. doi: 10.1093/bja/61.5.589. [DOI] [PubMed] [Google Scholar]