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. 1991 Feb;31(2):139–142. doi: 10.1111/j.1365-2125.1991.tb05501.x

Inhibition of the metabolism of paracetamol by isoniazid.

M M Epstein 1, S D Nelson 1, J T Slattery 1, T F Kalhorn 1, R A Wall 1, J M Wright 1
PMCID: PMC1368379  PMID: 2049229

Abstract

1. The effect of isoniazid given daily for 7 days on paracetamol (acetaminophen) kinetics and metabolism was studied in 10 healthy volunteers. Paracetamol, 500 mg, was given before isoniazid, on day 7 of isoniazid administration, and 2 days after the last dose of isoniazid. 2. On day 7, isoniazid markedly inhibited the formation clearance of the glutathione and catechol metabolites by 69.7% and 62.2%, respectively. Total paracetamol clearance was lowered by 15.2%. There was no effect of isoniazid on the non-oxidative pathways of paracetamol elimination. 3. Two days after isoniazid was discontinued, paracetamol metabolism had returned to pre-isoniazid values.

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Selected References

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