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. 1993 Jan;34(1):129–133. doi: 10.1136/gut.34.1.129

Contractile activity of the human colon: lessons from 24 hour studies.

G Bassotti 1, M D Crowell 1, W E Whitehead 1
PMCID: PMC1374115  PMID: 8432443

Abstract

The motor function of the colon is probably the least understood of the various hollow viscera of the human body. This is partly because of the marked variability of colonic motor function and the short recording periods usually used, generally not exceeding three hours. Most of the data available on human colonic motility originate from investigations conducted in the most distal portions of the viscus, because of technical difficulties in reaching its proximal portions. Although attempts have been made to solve these problems through the ingestion of radiotelemetric pressure sensors, these efforts have been hampered by intermittent signal loss and the inability to control the location of the capsule within the gastrointestinal tract. To overcome these problems, techniques have recently been developed that permit prolonged recordings (24 hours or more) of myoelectrical and contractile activity of the human colon, with both perfused and solid-state manometric systems. The present paper reviews the current experience in 24 hour recording from the human colon, with a primary emphasis on the more forceful propulsive contractile activity associated with the so called mass movements.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bassotti G., Betti C., Imbimbo B. P., Pelli M. A., Morelli A. Colonic motor response to eating: a manometric investigation in proximal and distal portions of the viscus in man. Am J Gastroenterol. 1989 Feb;84(2):118–122. [PubMed] [Google Scholar]
  2. Bassotti G., Betti C., Pelli M. A., Morelli A. Extensive investigation on colonic motility with pharmacological testing is useful for selecting surgical options in patients with inertia colica. Am J Gastroenterol. 1992 Jan;87(1):143–147. [PubMed] [Google Scholar]
  3. Bassotti G., Betti C., Pelli M. A., Morelli A. Prolonged (24-hour) manometric recording of rectal contractile activity in patients with slow transient constipation. Digestion. 1991;49(2):72–77. doi: 10.1159/000200706. [DOI] [PubMed] [Google Scholar]
  4. Bassotti G., Gaburri M., Imbimbo B. P., Rossi L., Farroni F., Pelli M. A., Morelli A. Colonic mass movements in idiopathic chronic constipation. Gut. 1988 Sep;29(9):1173–1179. doi: 10.1136/gut.29.9.1173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bassotti G., Gaburri M. Manometric investigation of high-amplitude propagated contractile activity of the human colon. Am J Physiol. 1988 Nov;255(5 Pt 1):G660–G664. doi: 10.1152/ajpgi.1988.255.5.G660. [DOI] [PubMed] [Google Scholar]
  6. Bassotti G., Imbimbo B. P., Betti C., Erbella G. S., Pelli M. A., Morelli A. Edrophonium chloride for testing colonic contractile activity in man. Acta Physiol Scand. 1991 Mar;141(3):289–293. doi: 10.1111/j.1748-1716.1991.tb09083.x. [DOI] [PubMed] [Google Scholar]
  7. Browning C., Valori R. M., Wingate D. L. Receiving, decoding and noise limiting systems for a new pressure-sensitive ingestible radio telemetric capsule. J Biomed Eng. 1983 Jul;5(3):262–266. doi: 10.1016/0141-5425(83)90108-5. [DOI] [PubMed] [Google Scholar]
  8. CHAUDHARY N. A., TRUELOVE S. C. Human colonic motility: a comparative study of normal subjects, patients with ulcerative colitis, and patients with the irritable colon syndrome. I. Resting patterns of motility. Gastroenterology. 1961 Jan;40:1–17. [PubMed] [Google Scholar]
  9. Christensen J., Caprilli R., Lund G. F. Electric slow waves in circular muscle of cat colon. Am J Physiol. 1969 Sep;217(3):771–776. doi: 10.1152/ajplegacy.1969.217.3.771. [DOI] [PubMed] [Google Scholar]
  10. Christensen J. The response of the colon to eating. Am J Clin Nutr. 1985 Nov;42(5 Suppl):1025–1032. doi: 10.1093/ajcn/42.5.1025. [DOI] [PubMed] [Google Scholar]
  11. Cook I. J., Reddy S. N., Collins S. M., Daniel E. E. Influence of recording techniques on measurement of canine colonic motility. Dig Dis Sci. 1988 Aug;33(8):999–1006. doi: 10.1007/BF01535997. [DOI] [PubMed] [Google Scholar]
  12. Crowell M. D., Bassotti G., Cheskin L. J., Schuster M. M., Whitehead W. E. Method for prolonged ambulatory monitoring of high-amplitude propagated contractions from colon. Am J Physiol. 1991 Aug;261(2 Pt 1):G263–G268. doi: 10.1152/ajpgi.1991.261.2.G263. [DOI] [PubMed] [Google Scholar]
  13. Dinoso V. P., Jr, Murthy S. N., Goldstein J., Rosner B. Basal motor activity of the distal colon: a reappraisal. Gastroenterology. 1983 Sep;85(3):637–642. [PubMed] [Google Scholar]
  14. Dinoso V. P., Jr, Murthy S. N., Goldstein J., Rosner B. Basal motor activity of the distal colon: a reappraisal. Gastroenterology. 1983 Sep;85(3):637–642. [PubMed] [Google Scholar]
  15. Duthie H. L. Colonic response to eating. Gastroenterology. 1978 Sep;75(3):527–528. [PubMed] [Google Scholar]
  16. El-Sharkawy T. Y. Electrical activities of the muscle layers of the canine colon. J Physiol. 1983 Sep;342:67–83. doi: 10.1113/jphysiol.1983.sp014840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Frexinos J., Bueno L., Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology. 1985 May;88(5 Pt 1):1104–1110. doi: 10.1016/s0016-5085(85)80067-6. [DOI] [PubMed] [Google Scholar]
  18. Frexinos J., Fioramonti J., Bueno L. Réponse colique à l'alimentation (RCA). Régulation et anomalies. Gastroenterol Clin Biol. 1986 Dec;10(12):837–840. [PubMed] [Google Scholar]
  19. Garcia D., Hita G., Mompean B., Hernandez A., Pellicer E., Morales G., Parrilla P. Colonic motility: electric and manometric description of mass movement. Dis Colon Rectum. 1991 Jul;34(7):577–584. doi: 10.1007/BF02049898. [DOI] [PubMed] [Google Scholar]
  20. Hagihara P. F., Griffen W. O., Jr Physiology of the colon and rectum. Surg Clin North Am. 1972 Aug;52(4):797–805. doi: 10.1016/s0039-6109(16)39779-1. [DOI] [PubMed] [Google Scholar]
  21. Hardcastle J. D., Mann C. V. Physical factors in the stimulation of colonic peristalsis. Gut. 1970 Jan;11(1):41–46. doi: 10.1136/gut.11.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hardcastle J. D., Mann C. V. Study of large bowel peristalsis. Gut. 1968 Oct;9(5):512–520. doi: 10.1136/gut.9.5.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Hertz A. F., Newton A. The normal movements of the colon in man. J Physiol. 1913 Oct 17;47(1-2):57–65. doi: 10.1113/jphysiol.1913.sp001613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Holdstock D. J., Misiewicz J. J., Smith T., Rowlands E. N. Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. Gut. 1970 Feb;11(2):91–99. doi: 10.1136/gut.11.2.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Huizinga J. D., Daniel E. E. Control of human colonic motor function. Dig Dis Sci. 1986 Aug;31(8):865–877. doi: 10.1007/BF01296057. [DOI] [PubMed] [Google Scholar]
  26. Kamm M. A., Hawley P. R., Lennard-Jones J. E. Outcome of colectomy for severe idiopathic constipation. Gut. 1988 Jul;29(7):969–973. doi: 10.1136/gut.29.7.969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Kerlin P., Zinsmeister A., Phillips S. Motor responses to food of the ileum, proximal colon, and distal colon of healthy humans. Gastroenterology. 1983 Apr;84(4):762–770. [PubMed] [Google Scholar]
  28. Krevsky B., Malmud L. S., D'Ercole F., Maurer A. H., Fisher R. S. Colonic transit scintigraphy. A physiologic approach to the quantitative measurement of colonic transit in humans. Gastroenterology. 1986 Nov;91(5):1102–1112. [PubMed] [Google Scholar]
  29. Kumar D., Williams N. S., Waldron D., Wingate D. L. Prolonged manometric recording of anorectal motor activity in ambulant human subjects: evidence of periodic activity. Gut. 1989 Jul;30(7):1007–1011. doi: 10.1136/gut.30.7.1007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Leon S. H., Krishnamurthy S., Schuffler M. D. Subtotal colectomy for severe idiopathic constipation. A follow-up study of 13 patients. Dig Dis Sci. 1987 Nov;32(11):1249–1254. doi: 10.1007/BF01296374. [DOI] [PubMed] [Google Scholar]
  31. Lind C. D. Motility disorders in the irritable bowel syndrome. Gastroenterol Clin North Am. 1991 Jun;20(2):279–295. [PubMed] [Google Scholar]
  32. Misiewicz J. J. Colonic motility. Gut. 1975 Apr;16(4):311–314. doi: 10.1136/gut.16.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Misiewicz J. J., Connell A. M., Pontes F. A. Comparison of the effect of meals and prostigmine on the proximal and distal colon in patients with and without diarrhoea. Gut. 1966 Oct;7(5):468–473. doi: 10.1136/gut.7.5.468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Misiewicz J. J. Measurement of intraluminal pressures: radiotelemetry, design of manometric studies, and computer analysis of records. Am J Dig Dis. 1968 May;13(5):389–396. doi: 10.1007/BF02233655. [DOI] [PubMed] [Google Scholar]
  35. Moreno-Osset E., Bazzocchi G., Lo S., Trombley B., Ristow E., Reddy S. N., Villanueva-Meyer J., Fain J. W., Jing J., Mena I. Association between postprandial changes in colonic intraluminal pressure and transit. Gastroenterology. 1989 May;96(5 Pt 1):1265–1273. doi: 10.1016/s0016-5085(89)80013-7. [DOI] [PubMed] [Google Scholar]
  36. Narducci F., Bassotti G., Daniotti S., Del Soldato P., Pelli M. A., Morelli A. Identification of muscarinic receptor subtype mediating colonic response to eating. Dig Dis Sci. 1985 Feb;30(2):124–128. doi: 10.1007/BF01308197. [DOI] [PubMed] [Google Scholar]
  37. Narducci F., Bassotti G., Gaburri M., Morelli A. Twenty four hour manometric recording of colonic motor activity in healthy man. Gut. 1987 Jan;28(1):17–25. doi: 10.1136/gut.28.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Orkin B. A., Hanson R. B., Kelly K. A., Phillips S. F., Dent J. Human anal motility while fasting, after feeding, and during sleep. Gastroenterology. 1991 Apr;100(4):1016–1023. doi: 10.1016/0016-5085(91)90277-r. [DOI] [PubMed] [Google Scholar]
  39. POSEY E. L., Jr, BARGEN J. A. Observations of normal and abnormal human intestinal motor function. Am J Med Sci. 1951 Jan;221(1):10–20. doi: 10.1097/00000441-195101000-00003. [DOI] [PubMed] [Google Scholar]
  40. Pinho M., Yoshioka K., Keighley M. R. Long term results of anorectal myectomy for chronic constipation. Br J Surg. 1989 Nov;76(11):1163–1164. doi: 10.1002/bjs.1800761117. [DOI] [PubMed] [Google Scholar]
  41. RAMORINO M. L., COLAGRANDE C. INTESTINAL MOTILITY: PRELIMINARY STUDIES WITH TELEMETERING CAPSULES AND SYNCHRONIZED FLUOROCINEMATOGRAPHY. Am J Dig Dis. 1964 Jan;9:64–71. doi: 10.1007/BF02232680. [DOI] [PubMed] [Google Scholar]
  42. RITCHIE J. A., ARDRAN G. M., TRUELOVE S. C. Motor activity of the sigmoid colon of humans. A combined study by intraluminal pressure recording and cineradiography. Gastroenterology. 1962 Dec;43:642–668. [PubMed] [Google Scholar]
  43. ROSENBLUM M. J., CUMMINS A. J. The effect of sleep and of amytal on the motor activity of the human sigmoid colon. Gastroenterology. 1954 Oct;27(4):445–450. [PubMed] [Google Scholar]
  44. Ritchie J. A. Colonic motor activity and bowel function. I. Normal movement of contents. Gut. 1968 Aug;9(4):442–456. doi: 10.1136/gut.9.4.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Ritchie J. A. Movement of segmental constrictions in the human colon. Gut. 1971 May;12(5):350–355. doi: 10.1136/gut.12.5.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Ritchie J. Mass peristalsis in the human colon after contact with oxyphenisatin. Gut. 1972 Mar;13(3):211–219. doi: 10.1136/gut.13.3.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Sarna S. K., Condon R., Cowles V. Colonic migrating and nonmigrating motor complexes in dogs. Am J Physiol. 1984 Apr;246(4 Pt 1):G355–G360. doi: 10.1152/ajpgi.1984.246.4.G355. [DOI] [PubMed] [Google Scholar]
  48. Sarna S. K. Physiology and pathophysiology of colonic motor activity (1). Dig Dis Sci. 1991 Jun;36(6):827–862. doi: 10.1007/BF01311244. [DOI] [PubMed] [Google Scholar]
  49. Schuurkes J. A., Tukker J. J. The interdigestive colonic motor complex of the dog. Arch Int Pharmacodyn Ther. 1980 Oct;247(2):329–334. [PubMed] [Google Scholar]
  50. Snape W. J., Jr, Matarazzo S. A., Cohen S. Effect of eating and gastrointestinal hormones on human colonic myoelectrical and motor activity. Gastroenterology. 1978 Sep;75(3):373–378. [PubMed] [Google Scholar]
  51. Snape W. J., Jr, Wright S. H., Battle W. M., Cohen S. The gastrocolic response: evidence for a neural mechanism. Gastroenterology. 1979 Dec;77(6):1235–1240. [PubMed] [Google Scholar]
  52. Soffer E. E., Scalabrini P., Wingate D. L. Prolonged ambulant monitoring of human colonic motility. Am J Physiol. 1989 Oct;257(4 Pt 1):G601–G606. doi: 10.1152/ajpgi.1989.257.4.G601. [DOI] [PubMed] [Google Scholar]
  53. Steadman C. J., Phillips S. F., Camilleri M., Haddad A. C., Hanson R. B. Variation of muscle tone in the human colon. Gastroenterology. 1991 Aug;101(2):373–381. doi: 10.1016/0016-5085(91)90014-c. [DOI] [PubMed] [Google Scholar]
  54. Torsoli A., Ramorino M. L., Ammaturo M. V., Capurso L., Paoluzi P., Anzini F. Mass movements and intracolonic pressures. Am J Dig Dis. 1971 Aug;16(8):693–696. doi: 10.1007/BF02239591. [DOI] [PubMed] [Google Scholar]
  55. Torsoli A., Ramorino M. L., Crucioli V. The relationships between anatomy and motor activity of the colon. Am J Dig Dis. 1968 May;13(5):462–467. doi: 10.1007/BF02233670. [DOI] [PubMed] [Google Scholar]
  56. Vasilevsky C. A., Nemer F. D., Balcos E. G., Christenson C. E., Goldberg S. M. Is subtotal colectomy a viable option in the management of chronic constipation? Dis Colon Rectum. 1988 Sep;31(9):679–681. doi: 10.1007/BF02552582. [DOI] [PubMed] [Google Scholar]
  57. Waldron D. J., Kumar D., Hallan R. I., Wingate D. L., Williams N. S. Evidence for motor neuropathy and reduced filling of the rectum in chronic intractable constipation. Gut. 1990 Nov;31(11):1284–1288. doi: 10.1136/gut.31.11.1284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Wyman J. B., Heaton K. W., Manning A. P., Wicks A. C. Variability of colonic function in healthy subjects. Gut. 1978 Feb;19(2):146–150. doi: 10.1136/gut.19.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Yoshioka K., Keighley M. R. Clinical results of colectomy for severe constipation. Br J Surg. 1989 Jun;76(6):600–604. doi: 10.1002/bjs.1800760625. [DOI] [PubMed] [Google Scholar]

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