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. 1993 Oct;34(10):1389–1393. doi: 10.1136/gut.34.10.1389

Non-penetrance and late appearance of polyps in families with familial adenomatous polyposis.

D G Evans 1, S P Guy 1, N Thakker 1, J G Armstrong 1, C Dodd 1, D R Davies 1, C Babbs 1, T Clancy 1, T Warnes 1, P Sloan 1, et al.
PMCID: PMC1374547  PMID: 8244107

Abstract

One case of non-penetrance of the familial adenomatous polyposis (FAP) gene at 59 years of age and late onset of polyps on endoscopy and biopsy in this and two other families is described. Screening protocols should include dental screening as well as indirect ophthalmoscopy and endoscopy to detect minimal manifestations of the gene. In the absence of a specific DNA predictive test, bowel screening should continue well beyond 30 years of age.

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Selected References

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