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. 1994 Jul;35(7):884–890. doi: 10.1136/gut.35.7.884

Effects of intraluminal acidification on oesophageal motor activity.

I Bontempo 1, L Piretta 1, E Corazziari 1, F Michetti 1, F Anzini 1, A Torsoli 1
PMCID: PMC1374833  PMID: 8063214

Abstract

This study assessed the effect of prolonged intraluminal acidification on the motor activity of the entire oesophageal body (under controlled conditions). Intraoesophageal pressures were recorded in 13 endoscopy negative subjects with gastro-oesophageal reflux disease in whom saline, HC1 0.1 N, and saline solutions were infused (1.5 ml/min) blindly in the oesophageal body, 6 cm distal to the upper oesophageal sphincter for three consecutive periods of 45 minutes each. These findings were compared with those of a control group. Intraoesophageal acidification caused an increase in the deglutition frequency (p < 0.02), the occurrence of multipeaked waves (p < 0.04) as well as a decrease of the propagating velocity (p < 0.04) of the primary peristaltic contractions. Furthermore, intraoesophageal acidification determined an increase, at all levels of the oesophagus, of the duration (p < 0.04) and, more noticeable in the proximal oesophageal body, of the amplitude (p < 0.02) of primary peristaltic contraction waves. In conclusion prolonged intraoesophageal acidification can considerably affect frequency of deglutition, morphology, and propagating patterns of primary peristaltic contractions. This study shows that these effects are independent from volume distension of the oesophagus and supports the presence of acid sensitive receptors in the oesophageal mucosa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahtaridis G., Snape W. J., Jr, Cohen S. Lower esophageal sphincter pressure as an index of gastroesophageal acid reflux. Dig Dis Sci. 1981 Nov;26(11):993–998. doi: 10.1007/BF01314761. [DOI] [PubMed] [Google Scholar]
  2. Burns T. W., Venturatos S. G. Esophageal motor function and response to acid perfusion in patients with symptomatic reflux esophagitis. Dig Dis Sci. 1985 Jun;30(6):529–535. doi: 10.1007/BF01320258. [DOI] [PubMed] [Google Scholar]
  3. Campo S., Traube M. Lower esophageal sphincter dysfunction in diffuse esophageal spasm. Am J Gastroenterol. 1989 Aug;84(8):928–932. [PubMed] [Google Scholar]
  4. Cohen S., Harris L. D. The lower esophageal sphincter. Gastroenterology. 1972 Dec;63(6):1066–1073. [PubMed] [Google Scholar]
  5. Corazziari E., Materia E., Pozzessere C., Anzini F., Torsoli A. Intraluminal pH and oesophageal motility in patients with gastro-oesophageal reflux. Digestion. 1986;35(3):151–157. doi: 10.1159/000199361. [DOI] [PubMed] [Google Scholar]
  6. Corazziari E., Pozzessere C., Dani S., Anzini F., Torsoli A. Intraluminal pH esophageal motility. Gastroenterology. 1978 Aug;75(2):275–277. [PubMed] [Google Scholar]
  7. De Caestecker J. S., Pryde A., Heading R. C. Comparison of intravenous edrophonium and oesophageal acid perfusion during oesophageal manometry in patients with non-cardiac chest pain. Gut. 1988 Aug;29(8):1029–1034. doi: 10.1136/gut.29.8.1029. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Garabedian M. Uses of esophageal manometry and acid perfusion in the study of gastroesophageal reflux and hiatal hernia. Surg Clin North Am. 1971 Jun;51(3):589–596. doi: 10.1016/s0039-6109(16)39433-6. [DOI] [PubMed] [Google Scholar]
  9. Helm J. F., Massey B. T., Martin C. J., Dodds W. J., Hogan W. J., Arndorfer R. C. Oesophageal acidification does not increase lower oesophageal sphincter pressure. Gut. 1990 Mar;31(3):266–269. doi: 10.1136/gut.31.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hollis J. B., Castell D. O. Effect of dry swallows and wet swallows of different volumes on esophageal peristalsis. J Appl Physiol. 1975 Jun;38(6):1161–1164. doi: 10.1152/jappl.1975.38.6.1161. [DOI] [PubMed] [Google Scholar]
  11. Kahrilas P. J., Dodds W. J., Hogan W. J., Kern M., Arndorfer R. C., Reece A. Esophageal peristaltic dysfunction in peptic esophagitis. Gastroenterology. 1986 Oct;91(4):897–904. doi: 10.1016/0016-5085(86)90692-x. [DOI] [PubMed] [Google Scholar]
  12. Katz P. O., Knuff T. E., Benjamin S. B., Castell D. O. Abnormal esophageal pressures in reflux esophagitis: cause or effect? Am J Gastroenterol. 1986 Sep;81(9):744–746. [PubMed] [Google Scholar]
  13. Kjellén G., Tibbling L. Oesophageal motility during acid-provoked heartburn and chest pain. Scand J Gastroenterol. 1985 Oct;20(8):937–940. doi: 10.3109/00365528509088851. [DOI] [PubMed] [Google Scholar]
  14. Madsen T., Wallin L., Boesby S., Larsen V. H. Spontaneous peristaltic activity in the oesophagus after imitated acid gastro-oesophageal reflux. A study in normal subjects. Scand J Gastroenterol. 1982 Sep;17(6):811–815. doi: 10.3109/00365528209181098. [DOI] [PubMed] [Google Scholar]
  15. Richter J. E., Johns D. N., Wu W. C., Castell D. O. Are esophageal motility abnormalities produced during the intraesophageal acid perfusion test? JAMA. 1985 Apr 5;253(13):1914–1917. [PubMed] [Google Scholar]
  16. SIEGEL C. I., HENDRIX T. R. Esophageal motor abnormalities induced by acid perfusion in patients with heartburn. J Clin Invest. 1963 May;42:686–695. doi: 10.1172/JCI104760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Skinner D. B., Booth D. J. Assessment of distal esophageal function in patients with hiatal hernia and-or gastroesophageal reflux. Ann Surg. 1970 Oct;172(4):627–637. doi: 10.1097/00000658-197010000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Thurer R. L., Demeester T. R., Johnson L. F. The distal esophageal sphincter and its relationship to gastroesophageal reflux. J Surg Res. 1974 Apr;16(4):418–423. doi: 10.1016/0022-4804(74)90063-8. [DOI] [PubMed] [Google Scholar]

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