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. 1994 Oct;35(10):1433–1438. doi: 10.1136/gut.35.10.1433

Incidence of inflammatory bowel disease in northern France (1988-1990).

C Gower-Rousseau 1, J L Salomez 1, J L Dupas 1, R Marti 1, M C Nuttens 1, A Votte 1, M Lemahieu 1, B Lemaire 1, J F Colombel 1, A Cortot 1
PMCID: PMC1375020  PMID: 7959201

Abstract

There were no data concerning the incidence of inflammatory bowel disease (IBD) in France. The aim of this study was to investigate the incidence of Crohn's disease and ulcerative colitis in northern France. This prospective population based study was realised through the gastroenterologists of the region Nord-Pas de Calais and the Somme Department. Each gastroenterologist referred patients consulting for the first time with clinical symptoms compatible with IBD. Data were collected by an interviewer practitioner present at the gastroenterologist's consulting room. Two independent expert gastroenterologists assessed each case in a blind manner and made a final diagnosis of Crohn's disease, ulcerative colitis, ulcerative proctitis, or unclassifiable chronic colitis. From 1988 to 1990, 1291 cases of IBD were recorded: 674 (52%) Crohn's disease, 466 (36%) ulcerative colitis including 162 proctitis (35%), and 151 (12%) unclassifiable chronic colitis. The mean annual incidence was 4.9 per 100,000 for Crohn's disease and 3.2 for ulcerative colitis. The sex ratio F/M was 1.3 for Crohn's disease and 0.8 for ulcerative colitis. The highest age specific incidence rate for Crohn's disease was between 20 and 29 years: 13.1 for women and 9.8 for men. The highest age specific incidence rate for ulcerative colitis was between 20 and 39 years: 5.5 for women and 6.5 for men. This first French prospective study has shown an incidence rate for Crohn's disease comparable with that seen in north European studies but lower than that seen for ulcerative colitis. These results could be related to the different environmental factors or the genetic background of the population studied, or both.

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Selected References

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  1. Benoni C., Nilsson A. Smoking habits in patients with inflammatory bowel disease. Scand J Gastroenterol. 1984 Sep;19(6):824–830. [PubMed] [Google Scholar]
  2. Bergman L., Krause U. The incidence of Crohn's disease in central Sweden. Scand J Gastroenterol. 1975;10(7):725–729. [PubMed] [Google Scholar]
  3. Berner J., Kiaer T. Ulcerative colitis and Crohn's disease on the Faroe Islands 1964-83. A retrospective epidemiological survey. Scand J Gastroenterol. 1986 Mar;21(2):188–192. doi: 10.3109/00365528609034645. [DOI] [PubMed] [Google Scholar]
  4. Binder V., Both H., Hansen P. K., Hendriksen C., Kreiner S., Torp-Pedersen K. Incidence and prevalence of ulcerative colitis and Crohn's disease in the County of Copenhagen, 1962 to 1978. Gastroenterology. 1982 Sep;83(3):563–568. [PubMed] [Google Scholar]
  5. Boyko E. J., Koepsell T. D., Perera D. R., Inui T. S. Risk of ulcerative colitis among former and current cigarette smokers. N Engl J Med. 1987 Mar 19;316(12):707–710. doi: 10.1056/NEJM198703193161202. [DOI] [PubMed] [Google Scholar]
  6. Brahme F., Lindström C., Wenckert A. Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden. Gastroenterology. 1975 Aug;69(2):342–351. [PubMed] [Google Scholar]
  7. Calkins B. M., Lilienfeld A. M., Garland C. F., Mendeloff A. I. Trends in incidence rates of ulcerative colitis and Crohn's disease. Dig Dis Sci. 1984 Oct;29(10):913–920. doi: 10.1007/BF01312480. [DOI] [PubMed] [Google Scholar]
  8. Daiss W., Scheurlen M., Malchow H. Epidemiology of inflammatory bowel disease in the county of Tübingen (West Germany). Scand J Gastroenterol Suppl. 1989;170:39–55. doi: 10.3109/00365528909091349. [DOI] [PubMed] [Google Scholar]
  9. Devlin H. B., Datta D., Dellipiani A. W. The incidence and prevalence of inflammatory bowel disease in North Tees Health District. World J Surg. 1980;4(2):183–193. doi: 10.1007/BF02393573. [DOI] [PubMed] [Google Scholar]
  10. Ekbom A., Helmick C., Zack M., Adami H. O. The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. Gastroenterology. 1991 Feb;100(2):350–358. doi: 10.1016/0016-5085(91)90202-v. [DOI] [PubMed] [Google Scholar]
  11. Evans J. G., Acheson E. D. An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area. Gut. 1965 Aug;6(4):311–324. doi: 10.1136/gut.6.4.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Fellows I. W., Freeman J. G., Holmes G. K. Crohn's disease in the city of Derby, 1951-85. Gut. 1990 Nov;31(11):1262–1265. doi: 10.1136/gut.31.11.1262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Garland C. F., Lilienfeld A. M., Mendeloff A. I., Markowitz J. A., Terrell K. B., Garland F. C. Incidence rates of ulcerative colitis and Crohn's disease in fifteen areas of the United States. Gastroenterology. 1981 Dec;81(6):1115–1124. [PubMed] [Google Scholar]
  14. Gilat T., Ribak J., Benaroya Y., Zemishlany Z., Weissman I. Ulcerative colitis in the Jewish population of Tel-Aviv Jafo. I. Epidemiology. Gastroenterology. 1974 Mar;66(3):335–342. [PubMed] [Google Scholar]
  15. Gollop J. H., Phillips S. F., Melton L. J., 3rd, Zinsmeister A. R. Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982. Gut. 1988 Jan;29(1):49–56. doi: 10.1136/gut.29.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Halme L., von Smitten K., Husa A. The incidence of Crohn's disease in the Helsinki metropolitan area during 1975-1985. Ann Chir Gynaecol. 1989;78(2):115–119. [PubMed] [Google Scholar]
  17. Haug K., Schrumpf E., Halvorsen J. F., Fluge G., Hamre E., Hamre T., Skjøllingstad R. Epidemiology of Crohn's disease in western Norway. Study group of Inflammatory Bowel Disease in Western Norway. Scand J Gastroenterol. 1989 Dec;24(10):1271–1275. doi: 10.3109/00365528909090798. [DOI] [PubMed] [Google Scholar]
  18. Hellers G. Crohn's disease in Stockholm county 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis. Acta Chir Scand Suppl. 1979;490:1–84. [PubMed] [Google Scholar]
  19. Jick H., Walker A. M. Cigarette smoking and ulcerative colitis. N Engl J Med. 1983 Feb 3;308(5):261–263. doi: 10.1056/NEJM198302033080507. [DOI] [PubMed] [Google Scholar]
  20. Kildebo S., Breckan R., Nordgaard K., Burhol P. G., Jorde R. The incidence of Crohn's disease in northern Norway from 1983 to 1986. Northern Norway Gastroenterology Society. Scand J Gastroenterol. 1989 Dec;24(10):1265–1270. doi: 10.3109/00365528909090797. [DOI] [PubMed] [Google Scholar]
  21. Kyle J. Crohn's disease in the northeastern and northern Isles of Scotland: an epidemiological review. Gastroenterology. 1992 Aug;103(2):392–399. doi: 10.1016/0016-5085(92)90826-k. [DOI] [PubMed] [Google Scholar]
  22. Lee F. I., Costello F. T. Crohn's disease in Blackpool--incidence and prevalence 1968-80. Gut. 1985 Mar;26(3):274–278. doi: 10.1136/gut.26.3.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Munkholm P., Langholz E., Nielsen O. H., Kreiner S., Binder V. Incidence and prevalence of Crohn's disease in the county of Copenhagen, 1962-87: a sixfold increase in incidence. Scand J Gastroenterol. 1992 Jul;27(7):609–614. doi: 10.3109/00365529209000127. [DOI] [PubMed] [Google Scholar]
  24. Nordenvall B., Broström O., Berglund M., Monsen U., Nordenström J., Sörstad J., Hellers G. Incidence of ulcerative colitis in Stockholm County 1955-1979. Scand J Gastroenterol. 1985 Sep;20(7):783–790. doi: 10.3109/00365528509088823. [DOI] [PubMed] [Google Scholar]
  25. Norlén B. J., Krause U., Bergman L. An epidemiological study of Crohn's disease. Scand J Gastroenterol. 1970;5(5):385–390. [PubMed] [Google Scholar]
  26. Notteghem B., Salomez J. L., Gower-Rousseau C., Marti R., Lemahieu M., Nuttens M. C., Dupas J. L., Colombel J. F., Cortot A. Que deviennent les colites aiguës inclassées? Résultats d'une étude de cohorte de 104 malades dans la région Nord-Pas-de-Calais. Registre des Maladies Inflammatoires du Tube Digestif du Nord-Quest de la France. Gastroenterol Clin Biol. 1993;17(11):811–815. [PubMed] [Google Scholar]
  27. Reumaux D., Delecourt L., Colombel J. F., Noël L. H., Duthilleul P., Cortot A. Anti-neutrophil cytoplasmic autoantibodies in relatives of patients with ulcerative colitis. Gastroenterology. 1992 Nov;103(5):1706–1706. doi: 10.1016/0016-5085(92)91208-l. [DOI] [PubMed] [Google Scholar]
  28. Ritchie J. K., Powell-Tuck J., Lennard-Jones J. E. Clinical outcome of the first ten years of ulcerative colitis and proctitis. Lancet. 1978 May 27;1(8074):1140–1143. doi: 10.1016/s0140-6736(78)90312-4. [DOI] [PubMed] [Google Scholar]
  29. Rose J. D., Roberts G. M., Williams G., Mayberry J. F., Rhodes J. Cardiff Crohn's disease jubilee: the incidence over 50 years. Gut. 1988 Mar;29(3):346–351. doi: 10.1136/gut.29.3.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Sedlack R. E., Nobrega F. T., Kurland L. T., Sauer W. G. Inflammatory colon disease in Rochester, Minnesota, 1935-1964. Gastroenterology. 1972 May;62(5):935–941. [PubMed] [Google Scholar]
  31. Sedlack R. E., Whisnant J., Elveback L. R., Kurland L. T. Incidence of Crohn's disease in Olmsted County, Minnesota, 1935-1975. Am J Epidemiol. 1980 Dec;112(6):759–763. doi: 10.1093/oxfordjournals.aje.a113048. [DOI] [PubMed] [Google Scholar]
  32. Shanahan F., Duerr R. H., Rotter J. I., Yang H., Sutherland L. R., McElree C., Landers C. J., Targan S. R. Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology. 1992 Aug;103(2):456–461. doi: 10.1016/0016-5085(92)90834-l. [DOI] [PubMed] [Google Scholar]
  33. Shivananda S., Hordijk M. L., Ten Kate F. J., Probert C. S., Mayberry J. F. Differential diagnosis of inflammatory bowel disease. A comparison of various diagnostic classifications. Scand J Gastroenterol. 1991 Feb;26(2):167–173. doi: 10.3109/00365529109025027. [DOI] [PubMed] [Google Scholar]
  34. Shivananda S., Peña A. S., Nap M., Weterman I. T., Mayberry J. F., Ruitenberg E. J., Hoedemaeker P. J. Epidemiology of Crohn's disease in Regio Leiden, The Netherlands. A population study from 1979 to 1983. Gastroenterology. 1987 Nov;93(5):966–974. doi: 10.1016/0016-5085(87)90558-0. [DOI] [PubMed] [Google Scholar]
  35. Sonnenberg A. Geographic variation in the incidence of and mortality from inflammatory bowel disease. Dis Colon Rectum. 1986 Dec;29(12):854–861. doi: 10.1007/BF02555363. [DOI] [PubMed] [Google Scholar]
  36. Sonnenberg A., McCarty D. J., Jacobsen S. J. Geographic variation of inflammatory bowel disease within the United States. Gastroenterology. 1991 Jan;100(1):143–149. doi: 10.1016/0016-5085(91)90594-b. [DOI] [PubMed] [Google Scholar]
  37. Stonnington C. M., Phillips S. F., Melton L. J., 3rd, Zinsmeister A. R. Chronic ulcerative colitis: incidence and prevalence in a community. Gut. 1987 Apr;28(4):402–409. doi: 10.1136/gut.28.4.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Stowe S. P., Redmond S. R., Stormont J. M., Shah A. N., Chessin L. N., Segal H. L., Chey W. Y. An epidemiologic study of inflammatory bowel disease in Rochester, New York. Hospital incidence. Gastroenterology. 1990 Jan;98(1):104–110. doi: 10.1016/0016-5085(90)91297-j. [DOI] [PubMed] [Google Scholar]
  39. Tobin M. V., Logan R. F., Langman M. J., McConnell R. B., Gilmore I. T. Cigarette smoking and inflammatory bowel disease. Gastroenterology. 1987 Aug;93(2):316–321. doi: 10.1016/0016-5085(87)91021-3. [DOI] [PubMed] [Google Scholar]

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