Skip to main content
PMC home page
Gut logoLink to Gut
. 1993 Sep;34(9):1210–1214. doi: 10.1136/gut.34.9.1210

In vivo rectal inflammatory mediator changes with radiotherapy to the pelvis.

A T Cole 1, K Slater 1, M Sokal 1, C J Hawkey 1
PMCID: PMC1375456  PMID: 8406156

Abstract

In vivo changes in the rectal values of eicosanoid inflammatory mediators induced by pelvic radiotherapy were measured to study the pathophysiology of the early radiation bowel reaction. Ten patients having pelvic radiotherapy, aged 57 to 78, had rectal dialysis. Values of the eicosanoids leukotriene B4 (LTB4), thromboxane B2 (TXB2), and prostaglandin E2 (PGE2) were measured before radiotherapy, at the end of radiotherapy, and at least four weeks after radiotherapy. Values of LTB4 rose with radiotherapy from 0.21 ng.ml-1 (median) to 1.14 ng.ml-1 (p = 0.012); PGE2 rose from 0.60 ng.ml-1 to 1.58 ng.ml-1 (p = 0.038), and TXB2 rose from 0.365 ng.ml-1 to 1.6 ng.ml-1 (p = 0.005). The rise in eicosanoid inflammatory mediators may have an important role in the pathophysiology of the early radiation bowel reaction.

Full text

PDF
1211

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alam I., Ohuchi K., Levine L. Determination of cyclooxygenase products and prostaglandin metabolites using high-pressure liquid chromatography and radioimmunoassay. Anal Biochem. 1979 Mar;93(2):339–345. doi: 10.1016/s0003-2697(79)80160-8. [DOI] [PubMed] [Google Scholar]
  2. Arlow F. L., Dekovich A. A., Priest R. J., Beher W. T. Bile acids in radiation-induced diarrhea. South Med J. 1987 Oct;80(10):1259–1261. doi: 10.1097/00007611-198710000-00015. [DOI] [PubMed] [Google Scholar]
  3. Barrow S. E., Ward P. S., Sleightholm M. A., Ritter J. M., Dollery C. T. Cigarette smoking: profiles of thromboxane- and prostacyclin-derived products in human urine. Biochim Biophys Acta. 1989 Oct 13;993(1):121–127. doi: 10.1016/0304-4165(89)90151-7. [DOI] [PubMed] [Google Scholar]
  4. Bloomer W. D., Hellman S. Normal tissue responses to radiation therapy. N Engl J Med. 1975 Jul 10;293(2):80–83. doi: 10.1056/NEJM197507102930206. [DOI] [PubMed] [Google Scholar]
  5. Bosch A., Frias Z. Complications after radiation therapy for cervical carcinoma. Acta Radiol Ther Phys Biol. 1977 May;16(1):53–62. doi: 10.3109/02841867709133933. [DOI] [PubMed] [Google Scholar]
  6. Brach M. A., Hass R., Sherman M. L., Gunji H., Weichselbaum R., Kufe D. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest. 1991 Aug;88(2):691–695. doi: 10.1172/JCI115354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chadwick V. S., Schlup M. M., Cooper B. T., Broom M. F. Enzymes degrading bacterial chemotactic F-met peptides in human ileal and colonic mucosa. J Gastroenterol Hepatol. 1990 Jul-Aug;5(4):375–381. doi: 10.1111/j.1440-1746.1990.tb01412.x. [DOI] [PubMed] [Google Scholar]
  8. Empey L. R., Papp J. D., Jewell L. D., Fedorak R. N. Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats. Dig Dis Sci. 1992 Feb;37(2):205–214. doi: 10.1007/BF01308173. [DOI] [PubMed] [Google Scholar]
  9. Evans M. L., Graham M. M., Mahler P. A., Rasey J. S. Use of steroids to suppress vascular response to radiation. Int J Radiat Oncol Biol Phys. 1987 Apr;13(4):563–567. doi: 10.1016/0360-3016(87)90072-1. [DOI] [PubMed] [Google Scholar]
  10. Gilinsky N. H., Burns D. G., Barbezat G. O., Levin W., Myers H. S., Marks I. N. The natural history of radiation-induced proctosigmoiditis: an analysis of 88 patients. Q J Med. 1983 Winter;52(205):40–53. [PubMed] [Google Scholar]
  11. Goldman G., Welbourn R., Valeri C. R., Shepro D., Hechtman H. B. Thromboxane A2 induces leukotriene B4 synthesis that in turn mediates neutrophil diapedesis via CD 18 activation. Microvasc Res. 1991 May;41(3):367–375. doi: 10.1016/0026-2862(91)90035-a. [DOI] [PubMed] [Google Scholar]
  12. Gresele P., Deckmyn H., Nenci G. G., Vermylen J. Thromboxane synthase inhibitors, thromboxane receptor antagonists and dual blockers in thrombotic disorders. Trends Pharmacol Sci. 1991 Apr;12(4):158–163. doi: 10.1016/0165-6147(91)90533-x. [DOI] [PubMed] [Google Scholar]
  13. Hanson W. R., DeLaurentiis K. Comparison of in vivo murine intestinal radiation protection by E-prostaglandins. Prostaglandins. 1987;33 (Suppl):93–104. doi: 10.1016/0090-6980(87)90052-9. [DOI] [PubMed] [Google Scholar]
  14. Hawkey C. J., Truelove S. C. Effect of prednisolone on prostaglandin synthesis by rectal mucosa in ulcerative colitis: investigation by laminar flow bioassay and radioimmunoassay. Gut. 1981 Mar;22(3):190–193. doi: 10.1136/gut.22.3.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Lauritsen K., Laursen L. S., Bukhave K., Rask-Madsen J. Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology. 1986 Oct;91(4):837–844. doi: 10.1016/0016-5085(86)90684-0. [DOI] [PubMed] [Google Scholar]
  16. McMillan R. M., Walker E. R. Designing therapeutically effective 5-lipoxygenase inhibitors. Trends Pharmacol Sci. 1992 Aug;13(8):323–330. doi: 10.1016/0165-6147(92)90100-k. [DOI] [PubMed] [Google Scholar]
  17. Mennie A. T., Dalley V. Aspirin in radiation-induced diarrhoea. Lancet. 1973 May 19;1(7812):1131–1131. doi: 10.1016/s0140-6736(73)90451-0. [DOI] [PubMed] [Google Scholar]
  18. Palmblad J., Malmsten C. L., Udén A. M., Rådmark O., Engstedt L., Samuelsson B. Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. Blood. 1981 Sep;58(3):658–661. [PubMed] [Google Scholar]
  19. Powell W. S. Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. Prostaglandins. 1980 Nov;20(5):947–957. doi: 10.1016/0090-6980(80)90144-6. [DOI] [PubMed] [Google Scholar]
  20. Rampton D. S., Sladen G. E., Youlten L. J. Rectal mucosal prostaglandin E2 release and its relation to disease activity, electrical potential difference, and treatment in ulcerative colitis. Gut. 1980 Jul;21(7):591–596. doi: 10.1136/gut.21.7.591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Weisbrot I. M., Liber A. F., Gordon B. S. The effects of therapeutic radiation on colonic mucosa. Cancer. 1975 Sep;36(3):931–940. doi: 10.1002/1097-0142(197509)36:3<931::aid-cncr2820360314>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES