Skip to main content
PMC home page
Gut logoLink to Gut
. 1990 Jul;31(7):767–769. doi: 10.1136/gut.31.7.767

Gastric emptying in patients with fundal gastritis and gastric cancer.

M Tatsuta 1, H Iishi 1, S Okuda 1
PMCID: PMC1378532  PMID: 2370013

Abstract

Gastric emptying was compared in patients with gastric cancers and fundal gastritis to determine its value in identifying patients at high risk of gastric cancer. Gastric emptying was measured by the acetaminophen absorption method, and the extent of fundal gastritis was determined by the endoscopic Congo red test. The results showed that gastric emptying was significantly slower in patients with severe fundal gastritis than in those without. Gastric emptying in patients with differentiated adenocarcinomas was significantly slower than in those with undifferentiated adenocarcinoma, its value being similar to that in patients with severe fundal gastritis. The Congo red test showed that the incidence of severe fundal gastritis was significantly greater in patients with differentiated adenocarcinomas than in those with undifferentiated cancers. These findings suggest that delayed gastric emptying may allow prolonged contact between dietary carcinogens and the stomach.

Full text

PDF
768

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ameer B., Greenblatt D. J., Divoll M., Abernethy D. R., Shargel L. High-performance liquid chromatographic determination of acetaminophen in plasma: single-dose pharmacokinetic studies. J Chromatogr. 1981 Nov 13;226(1):224–230. doi: 10.1016/s0378-4347(00)84226-7. [DOI] [PubMed] [Google Scholar]
  2. Clements J. A., Heading R. C., Nimmo W. S., Prescott L. F. Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther. 1978 Oct;24(4):420–431. doi: 10.1002/cpt1978244420. [DOI] [PubMed] [Google Scholar]
  3. Davies W. T., Kirkpatrick J. R., Owen G. M., Shields R. Gastric emptying in atrophic gastritis and carcinoma of the stomach. Scand J Gastroenterol. 1971;6(4):297–301. doi: 10.3109/00365527109181123. [DOI] [PubMed] [Google Scholar]
  4. Harasawa S., Tani N., Suzuki S., Miwa M., Sakita R., Nomiyama T., Miwa T. Gastric emptying in normal subjects and patients with peptic ulcer: a study using the acetaminophen method. Gastroenterol Jpn. 1979;14(1):1–10. doi: 10.1007/BF02774597. [DOI] [PubMed] [Google Scholar]
  5. Heading R. C., Nimmo J., Prescott L. F., Tothill P. The dependence of paracetamol absorption on the rate of gastric emptying. Br J Pharmacol. 1973 Feb;47(2):415–421. doi: 10.1111/j.1476-5381.1973.tb08339.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holt S., Heading R. C., Clements J. A., Tothill P., Prescott L. F. Acetaminophen absorption and metabolism in celiac disease and Crohn's disease. Clin Pharmacol Ther. 1981 Aug;30(2):232–238. doi: 10.1038/clpt.1981.153. [DOI] [PubMed] [Google Scholar]
  7. Kawamoto H., Yamamura H., Tatsuta M., Okuda S. Effect of glucagon on gastric motility examined by the acetaminophen absorption method and the endoscopic procedure. Arzneimittelforschung. 1985;35(9):1475–1477. [PubMed] [Google Scholar]
  8. Minami H., McCallum R. W. The physiology and pathophysiology of gastric emptying in humans. Gastroenterology. 1984 Jun;86(6):1592–1610. [PubMed] [Google Scholar]
  9. SOMMERS S. C. Constitutional aspects of gastric carcinoma. AMA Arch Pathol. 1958 Oct;66(4):487–493. [PubMed] [Google Scholar]
  10. Stemmermann G. N., Mower H. Gastritis, nitrosamines, and gastric cancer. J Clin Gastroenterol. 1981;3(Suppl 2):23–27. [PubMed] [Google Scholar]
  11. Tatsuta M., Iishi H., Okuda S. Gastric emptying and gastrointestinal symptoms in patients with atrophic gastritis and the effects of domperidone. Scand J Gastroenterol. 1989 Mar;24(2):251–256. doi: 10.3109/00365528909093043. [DOI] [PubMed] [Google Scholar]
  12. Tatsuta M., Iishi H., Okuda S. Location of peptic ulcers in relation to antral and fundal gastritis by chromoendoscopic follow-up examinations. Dig Dis Sci. 1986 Jan;31(1):7–11. doi: 10.1007/BF01347902. [DOI] [PubMed] [Google Scholar]
  13. Tatsuta M., Okuda S., Tamura H., Taniguchi H. Endoscopic diagnosis of early gastric cancer by the endoscopic Congo red-methylene blue test. Cancer. 1982 Dec 15;50(12):2956–2960. doi: 10.1002/1097-0142(19821215)50:12<2956::aid-cncr2820501242>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  14. Tatsuta M., Okuda S., Taniguchi H., Tamura H. Gross and histological types of early gastric carcinomas in relation to the acid-secreting area. Cancer. 1979 Jan;43(1):317–321. doi: 10.1002/1097-0142(197901)43:1<317::aid-cncr2820430146>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  15. Whitehead R., Truelove S. C., Gear M. W. The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens. J Clin Pathol. 1972 Jan;25(1):1–11. doi: 10.1136/jcp.25.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES