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. 1991 Mar;32(3):299–302. doi: 10.1136/gut.32.3.299

Autoimmune chronic active hepatitis in a family.

S Hodges 1, A Lobo-Yeo 1, P Donaldson 1, M S Tanner 1, D Vergani 1
PMCID: PMC1378838  PMID: 2013424

Abstract

A positive family history of autoimmune disease is common among patients with autoimmune chronic active hepatitis, but usually autoimmunity is directed at organs other than the liver. We document for the first time the multiple occurrence of autoimmune chronic active hepatitis in a family. Out of a sibship of seven, three sisters developed this, one sister developed coeliac and autoimmune thyroid disease, one sister showed serological signs of autoimmunity, while the two brothers were well with no signs of autoimmunity. HLA typing showed that in association with the female sex DR3 seems to be more important than B8 in conferring susceptibility to autoimmune chronic active hepatitis, at least in this family.

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Selected References

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  1. Bodmer W. F. The HLA system and disease. The Oliver Sharpey Lecture 1979. J R Coll Physicians Lond. 1980 Jan;14(1):43–50. [PMC free article] [PubMed] [Google Scholar]
  2. Galbraith R. M., Smith M., Mackenzie R. M., Tee D. E., Doniach D., Williams R. High prevalence of seroimmunologic abnormalities in relatives of patients with active chronic hepatitis or primary biliary cirrhosis. N Engl J Med. 1974 Jan 10;290(2):63–69. doi: 10.1056/NEJM197401102900201. [DOI] [PubMed] [Google Scholar]
  3. Joske R. A., Laurence B. H. Familial cirrhosis with autoimmune features and raised immunoglobulin levels. Gastroenterology. 1970 Oct;59(4):546–552. [PubMed] [Google Scholar]
  4. Kakumu S., Yata K., Kashio T. Immunoregulatory T-cell function in acute and chronic liver disease. Gastroenterology. 1980 Oct;79(4):613–619. [PubMed] [Google Scholar]
  5. Krawitt E. L., Kilby A. E., Albertini R. J., Schanfield M. S., Chastenay B. F., Harper P. C., Mickey R. M., McAuliffe T. L. Immunogenetic studies of autoimmune chronic active hepatitis: HLA, immunoglobulin allotypes and autoantibodies. Hepatology. 1987 Nov-Dec;7(6):1305–1310. doi: 10.1002/hep.1840070621. [DOI] [PubMed] [Google Scholar]
  6. LaRusso N. F., Summerskill W. H., McCall J. T. Abnormalities of chemical tests for copper metabolism in chronic active liver disease: differentiation from Wilson's disease. Gastroenterology. 1976 May;70(5 PT1):653–655. [PubMed] [Google Scholar]
  7. Lobo-Yeo A., Alviggi L., Mieli-Vergani G., Portmann B., Mowat A. P., Vergani D. Preferential activation of helper/inducer T lymphocytes in autoimmune chronic active hepatitis. Clin Exp Immunol. 1987 Jan;67(1):95–104. [PMC free article] [PubMed] [Google Scholar]
  8. Mackay I. R., Morris P. J. Association of autoimmune active chronic hepatitis with HL-A1,8. Lancet. 1972 Oct 14;2(7781):793–795. doi: 10.1016/s0140-6736(72)92149-6. [DOI] [PubMed] [Google Scholar]
  9. Mackay I. R., Tait B. D. HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies. Gastroenterology. 1980 Jul;79(1):95–98. [PubMed] [Google Scholar]
  10. Nouri-Aria K. T., Donaldson P. T., Hegarty J. E., Eddleston A. L., Williams R. HLA A1-B8-DR3 and suppressor cell function in first-degree relatives of patients with autoimmune chronic active hepatitis. J Hepatol. 1985;1(3):235–241. doi: 10.1016/s0168-8278(85)80051-9. [DOI] [PubMed] [Google Scholar]
  11. Odièvre M., Maggiore G., Homberg J. C., Saadoun F., Couroucé A. M., Yvart J., Hadchouel M., Alagille D. Seroimmunologic classification of chronic hepatitis in 57 children. Hepatology. 1983 May-Jun;3(3):407–409. doi: 10.1002/hep.1840030320. [DOI] [PubMed] [Google Scholar]
  12. RUGGIERI B. A., BAGGENSTOSS A. H., LOGAN G. B. Juvenile cirrhosis; a clinicopathologic study of twenty-seven cases. AMA J Dis Child. 1957 Jul;94(1):64–76. [PubMed] [Google Scholar]
  13. Scheuer P. J. Chronic hepatitis: a problem for the pathologist. Histopathology. 1977 Jan;1(1):5–19. doi: 10.1111/j.1365-2559.1977.tb01640.x. [DOI] [PubMed] [Google Scholar]
  14. Smallwood R. A., McIlveen B., Rosenoer V. M., Sherlock S. Copper kinetics in liver disease. Gut. 1971 Feb;12(2):139–144. doi: 10.1136/gut.12.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sternlieb I., Scheinberg I. H. The role of radiocopper in the diagnosis of Wilson's disease. Gastroenterology. 1979 Jul;77(1):138–142. [PubMed] [Google Scholar]
  16. Swarbrick E. T., Fairclough P. D., Campbell P. J., Levison D. A., Greenwood R. H., Baker L. R. Coeliac disease, chronic active hepatiti, and mesangiocapillary glomerulonephritis in the same patient. Lancet. 1980 Nov 15;2(8203):1084–1085. doi: 10.1016/s0140-6736(80)92309-0. [DOI] [PubMed] [Google Scholar]
  17. Williams A. J., Marsh J., Stableforth D. E. Cryptogenic fibrosing alveolitis, chronic active hepatitis and autoimmune haemolytic anaemia in the same patient. Br J Dis Chest. 1985 Apr;79(2):200–203. [PubMed] [Google Scholar]

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