Skip to main content
PMC home page
Gut logoLink to Gut
. 1991 Aug;32(8):881–885. doi: 10.1136/gut.32.8.881

Compliance of adolescents with coeliac disease with a gluten free diet.

M Mayer 1, L Greco 1, R Troncone 1, S Auricchio 1, M N Marsh 1
PMCID: PMC1378956  PMID: 1885070

Abstract

A cohort of 123 patients with coeliac disease, diagnosed in the first three years of life and followed up for at least 10 years, was reevaluated during the teenage period in terms of compliance with the diet and clinical state. Mucosal structure and lymphocytes were assessed in small intestinal biopsy specimens obtained from 36 subjects, by computerised image analysis. Of these adolescents with coeliac disease, 65% were adhering to a strict gluten free diet, 11.4% were on a gluten free diet but with occasional gluten intake, and 23.6% were on a gluten containing diet. Clinical symptoms occurred more frequently in patients on a gluten containing diet, but not in patients on a semi-strict diet. Occasional intake of small amounts (0.06-2 g/day) of gluten did not produce increased concentrations of antigliadin antibodies but resulted in an appreciably increased crypt epithelial volume and expanded crypt intraepithelial lymphocyte population.

Full text

PDF
882

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker P. G., Barry R. E., Read A. E. Detection of continuing gluten ingestion in treated coeliac patients. Br Med J. 1975 Mar 1;1(5956):486–488. doi: 10.1136/bmj.1.5956.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cooper B. T., Holmes G. K., Ferguson R., Cooke W. T. Celiac disease and malignancy. Medicine (Baltimore) 1980 Jul;59(4):249–261. doi: 10.1097/00005792-198007000-00002. [DOI] [PubMed] [Google Scholar]
  3. Ferguson A., Ziegler K. Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis. Gut. 1986 Jun;27(6):675–679. doi: 10.1136/gut.27.6.675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Guandalini S., Ventura A., Ansaldi N., Giunta A. M., Greco L., Lazzari R., Mastella G., Rubino A. Diagnosis of coeliac disease: time for a change? Arch Dis Child. 1989 Sep;64(9):1320–1325. doi: 10.1136/adc.64.9.1320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Harris O. D., Cooke W. T., Thompson H., Waterhouse J. A. Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967 Jun;42(6):899–912. doi: 10.1016/0002-9343(67)90071-x. [DOI] [PubMed] [Google Scholar]
  6. Holmes G. K., Prior P., Lane M. R., Pope D., Allan R. N. Malignancy in coeliac disease--effect of a gluten free diet. Gut. 1989 Mar;30(3):333–338. doi: 10.1136/gut.30.3.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Holmes G. K., Stokes P. L., Sorahan T. M., Prior P., Waterhouse J. A., Cooke W. T. Coeliac disease, gluten-free diet, and malignancy. Gut. 1976 Aug;17(8):612–619. doi: 10.1136/gut.17.8.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jackson P. T., Glasgow J. F., Thom R. Parents' understanding of coeliac disease and diet. Arch Dis Child. 1985 Jul;60(7):672–674. doi: 10.1136/adc.60.7.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kokkonen J., Viitanen A., Similä S. Coping with a coeliac diet after adolescence. Helv Paediatr Acta. 1989 Feb;43(4):261–265. [PubMed] [Google Scholar]
  10. Kuitunen P., Savilahti E., Verkasalo M. Late mucosal relapse in a boy with coeliac disease and cow's milk allergy. Acta Paediatr Scand. 1986 Mar;75(2):340–342. doi: 10.1111/j.1651-2227.1986.tb10212.x. [DOI] [PubMed] [Google Scholar]
  11. Kumar P. J., Walker-Smith J., Milla P., Harris G., Colyer J., Halliday R. The teenage coeliac: follow up study of 102 patients. Arch Dis Child. 1988 Aug;63(8):916–920. doi: 10.1136/adc.63.8.916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marsh M. N. Measurement of intra-epithelial lymphocytes. Gut. 1986 Dec;27(12):1516–1517. doi: 10.1136/gut.27.12.1516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Marsh M. N. Studies of intestinal lymphoid tissue. XI--The immunopathology of cell-mediated reactions in gluten sensitivity and other enteropathies. Scanning Microsc. 1988 Sep;2(3):1663–1684. [PubMed] [Google Scholar]
  14. Mayer M., Greco L., Troncone R., Grimaldi M., Pansa G. Early prediction of relapse during gluten challenge in childhood celiac disease. J Pediatr Gastroenterol Nutr. 1989 May;8(4):474–479. doi: 10.1097/00005176-198905000-00009. [DOI] [PubMed] [Google Scholar]
  15. Montgomery A. M., Goka A. K., Kumar P. J., Farthing M. J., Clark M. L. Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies. Gut. 1988 Nov;29(11):1564–1568. doi: 10.1136/gut.29.11.1564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mortimer P. E., Stewart J. S., Norman A. P., Booth C. C. Follow-up study of coeliac disease. Br Med J. 1968 Jul 6;3(5609):7–9. doi: 10.1136/bmj.3.5609.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Niazi N. M., Leigh R., Crowe P., Marsh M. N. Morphometric analysis of small intestinal mucosa. I. Methodology, epithelial volume compartments and enumeration of inter-epithelial space lymphocytes. Virchows Arch A Pathol Anat Histopathol. 1984;404(1):49–60. doi: 10.1007/BF00704250. [DOI] [PubMed] [Google Scholar]
  18. Paerregaard A., Vilien M., Krasilnikoff P. A., Gudmand-Høyer E. Supposed coeliac disease during childhood and its presentation 14-38 years later. Scand J Gastroenterol. 1988 Jan;23(1):65–70. doi: 10.3109/00365528809093849. [DOI] [PubMed] [Google Scholar]
  19. Sheldon W. Prognosis in early adult life of coeliac children treated with a gluten-free diet. Br Med J. 1969 May 17;2(5654):401–404. doi: 10.1136/bmj.2.5654.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stein H., Dienemann D., Sperling M., Zeitz M., Riecken E. O. Identification of a T cell lymphoma category derived from intestinal-mucosa-associated T cells. Lancet. 1988 Nov 5;2(8619):1053–1054. doi: 10.1016/S0140-6736(88)90068-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Weir D. G., Hourihane D. O. Coeliac disease during the teenage period: the value of serial serum folate estimations. Gut. 1974 Jun;15(6):450–457. doi: 10.1136/gut.15.6.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Young W. F., Pringle E. M. 110 children with coeliac disease, 1950-1969. Arch Dis Child. 1971 Aug;46(248):421–436. doi: 10.1136/adc.46.248.421. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES