Abstract
Ten healthy volunteers (six men and four women, aged 22-41 years) were studied in a crossover trial. The study was divided into three one week periods. During each period the subjects either ran on a treadmill, cycled on a bicycle ergometer, or rested in a chair for 1 hour every day. The exercise was performed at two thirds predicted maximum heart rate (equivalent to 50% VO2 max). The sequences were rotated; no studies were performed in the perimenstrual period. Transit was measured by the method of measuring the excretion of a single dose of radio-opaque markers; all stools were collected, weighed, and x rayed after the ingestion of radio-opaque markers. Dietary fibre and fluid intake were measured on the fourth day of each test period by 24 hour record. Lifestyle was otherwise unchanged. Transit time was dramatically accelerated by moderate exercise (both jogging and cycling); however, stool weight, defecation frequency, dietary fibre intake, and fluid intake did not change significantly. Whole gut transit changed from 51.2 hours (95% confidence intervals 41.9 to 60.5) at rest to 36.6 hours (31.6 to 39.2) when riding and 34.0 hours (28.8 to 39.2) when jogging. Riding and running both differed significantly from resting (p less than 0.01); the difference between riding and running was not significant.
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- BRADLEY S. E., CHILDS A. W., COMBES B., COURNAND A., WADE O. L., WHEELER H. O. The effect of exercise on the splanchnic blood flow and splanchnic blood volume in normal man. Clin Sci. 1956 Aug;15(3):457–463. [PubMed] [Google Scholar]
- Banister E. W., Griffiths J. Blood levels of adrenergic amines during exercise. J Appl Physiol. 1972 Nov;33(5):674–676. doi: 10.1152/jappl.1972.33.5.674. [DOI] [PubMed] [Google Scholar]
- Bingham S. A., Cummings J. H. Effect of exercise and physical fitness on large intestinal function. Gastroenterology. 1989 Dec;97(6):1389–1399. doi: 10.1016/0016-5085(89)90381-8. [DOI] [PubMed] [Google Scholar]
- Bloom S. R., Johnson R. H., Park D. M., Rennie M. J., Sulaiman W. R. Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals. J Physiol. 1976 Jun;258(1):1–18. doi: 10.1113/jphysiol.1976.sp011403. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brandsborg O., Christensen N. J., Galbo H., Brandsborg M., Løvgreen N. A. The effect of exercise, smoking and propranolol on serum gastrin in patients with duodenal ulcer and in vagotomized subjects. Scand J Clin Lab Invest. 1978 Sep;38(5):441–446. doi: 10.1080/00365517809108449. [DOI] [PubMed] [Google Scholar]
- Cammack J., Read N. W., Cann P. A., Greenwood B., Holgate A. M. Effect of prolonged exercise on the passage of a solid meal through the stomach and small intestine. Gut. 1982 Nov;23(11):957–961. doi: 10.1136/gut.23.11.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carr D. B., Bullen B. A., Skrinar G. S., Arnold M. A., Rosenblatt M., Beitins I. Z., Martin J. B., McArthur J. W. Physical conditioning facilitates the exercise-induced secretion of beta-endorphin and beta-lipotropin in women. N Engl J Med. 1981 Sep 3;305(10):560–563. doi: 10.1056/NEJM198109033051006. [DOI] [PubMed] [Google Scholar]
- Carrió I., Estorch M., Serra-Grima R., Ginjaume M., Notivol R., Calabuig R., Vilardell F. Gastric emptying in marathon runners. Gut. 1989 Feb;30(2):152–155. doi: 10.1136/gut.30.2.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clausen J. P. Effect of physical training on cardiovascular adjustments to exercise in man. Physiol Rev. 1977 Oct;57(4):779–815. doi: 10.1152/physrev.1977.57.4.779. [DOI] [PubMed] [Google Scholar]
- Costill D. L., Saltin B. Factors limiting gastric emptying during rest and exercise. J Appl Physiol. 1974 Nov;37(5):679–683. doi: 10.1152/jappl.1974.37.5.679. [DOI] [PubMed] [Google Scholar]
- Cummings J. H., Jenkins D. J., Wiggins H. S. Measurement of the mean transit time of dietary residue through the human gut. Gut. 1976 Mar;17(3):210–218. doi: 10.1136/gut.17.3.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies G. J., Crowder M., Reid B., Dickerson J. W. Bowel function measurements of individuals with different eating patterns. Gut. 1986 Feb;27(2):164–169. doi: 10.1136/gut.27.2.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Demers L. M., Harrison T. S., Halbert D. R., Santen R. J. Effect of prolonged exercise on plasma prostaglandin levels. Prostaglandins Med. 1981 Apr;6(4):413–418. doi: 10.1016/0161-4630(81)90073-2. [DOI] [PubMed] [Google Scholar]
- Feldman M., Nixon J. V. Effect of exercise on postprandial gastric secretion and emptying in humans. J Appl Physiol Respir Environ Exerc Physiol. 1982 Oct;53(4):851–854. doi: 10.1152/jappl.1982.53.4.851. [DOI] [PubMed] [Google Scholar]
- Fogoros R. N. 'Runner's trots'. Gastrointestinal disturbances in runners. JAMA. 1980 May 2;243(17):1743–1744. doi: 10.1001/jama.243.17.1743. [DOI] [PubMed] [Google Scholar]
- Frisch R. E., Wyshak G., Albright N. L., Albright T. E., Schiff I., Witschi J., Marguglio M. Lower lifetime occurrence of breast cancer and cancers of the reproductive system among former college athletes. Am J Clin Nutr. 1987 Jan;45(1 Suppl):328–335. doi: 10.1093/ajcn/45.1.328. [DOI] [PubMed] [Google Scholar]
- Galbo H., Holst J. J., Christensen N. J. Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. J Appl Physiol. 1975 Jan;38(1):70–76. doi: 10.1152/jappl.1975.38.1.70. [DOI] [PubMed] [Google Scholar]
- Garabrant D. H., Peters J. M., Mack T. M., Bernstein L. Job activity and colon cancer risk. Am J Epidemiol. 1984 Jun;119(6):1005–1014. doi: 10.1093/oxfordjournals.aje.a113805. [DOI] [PubMed] [Google Scholar]
- Gerhardsson M., Norell S. E., Kiviranta H., Pedersen N. L., Ahlbom A. Sedentary jobs and colon cancer. Am J Epidemiol. 1986 May;123(5):775–780. doi: 10.1093/oxfordjournals.aje.a114306. [DOI] [PubMed] [Google Scholar]
- Hartley L. H., Mason J. W., Hogan R. P., Jones L. G., Kotchen T. A., Mougey E. H., Wherry F. E., Pennington L. L., Ricketts P. T. Multiple hormonal responses to prolonged exercise in relation to physical training. J Appl Physiol. 1972 Nov;33(5):607–610. doi: 10.1152/jappl.1972.33.5.607. [DOI] [PubMed] [Google Scholar]
- Hilsted J., Galbo H., Sonne B., Schwartz T., Fahrenkrug J., de Muckadell O. B., Lauritsen K. B., Tronier B. Gastroenteropancreatic hormonal changes during exercise. Am J Physiol. 1980 Sep;239(3):G136–G140. doi: 10.1152/ajpgi.1980.239.3.G136. [DOI] [PubMed] [Google Scholar]
- Hinds J. P., Stoney B., Wald A. Does gender or the menstrual cycle affect colonic transit? Am J Gastroenterol. 1989 Feb;84(2):123–126. [PubMed] [Google Scholar]
- Husemann B., Neubauer M. G., Duhme C. Sitzende Tätigkeit und Rektum-Sigma-Karzinom. Onkologie. 1980 Aug;3(4):168–171. doi: 10.1159/000214787. [DOI] [PubMed] [Google Scholar]
- McMahon L. F., Jr, Ryan M. J., Larson D., Fisher R. L. Occult gastrointestinal blood loss in marathon runners. Ann Intern Med. 1984 Jun;100(6):846–847. doi: 10.7326/0003-4819-100-6-846. [DOI] [PubMed] [Google Scholar]
- Meshkinpour H., Kemp C., Fairshter R. Effect of aerobic exercise on mouth-to-cecum transit time. Gastroenterology. 1989 Mar;96(3):938–941. [PubMed] [Google Scholar]
- Porter A. M. Do some marathon runners bleed into the gut? Br Med J (Clin Res Ed) 1983 Nov 12;287(6403):1427–1427. doi: 10.1136/bmj.287.6403.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROWELL L. B., BLACKMON J. R., BRUCE R. A. INDOCYANINE GREEN CLEARANCE AND ESTIMATED HEPATIC BLOOD FLOW DURING MILD TO MAXIMAL EXERCISE IN UPRIGHT MAN. J Clin Invest. 1964 Aug;43:1677–1690. doi: 10.1172/JCI105043. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees W. D., Rhodes J. Altered bowel habit and menstruation. Lancet. 1976 Aug 28;2(7983):475–475. doi: 10.1016/s0140-6736(76)92575-7. [DOI] [PubMed] [Google Scholar]
- Scheuer J., Tipton C. M. Cardiovascular adaptations to physical training. Annu Rev Physiol. 1977;39:221–251. doi: 10.1146/annurev.ph.39.030177.001253. [DOI] [PubMed] [Google Scholar]
- Stewart J. G., Ahlquist D. A., McGill D. B., Ilstrup D. M., Schwartz S., Owen R. A. Gastrointestinal blood loss and anemia in runners. Ann Intern Med. 1984 Jun;100(6):843–845. doi: 10.7326/0003-4819-100-6-843. [DOI] [PubMed] [Google Scholar]
- Sullivan S. N. The effect of running on the gastrointestinal tract. J Clin Gastroenterol. 1984 Oct;6(5):461–465. doi: 10.1097/00004836-198410000-00013. [DOI] [PubMed] [Google Scholar]
- Sullivan S. N. The gastrointestinal symptoms of running. N Engl J Med. 1981 Apr 9;304(15):915–915. doi: 10.1056/nejm198104093041522. [DOI] [PubMed] [Google Scholar]
- Turnbull G. K., Thompson D. G., Day S., Martin J., Walker E., Lennard-Jones J. E. Relationships between symptoms, menstrual cycle and orocaecal transit in normal and constipated women. Gut. 1989 Jan;30(1):30–34. doi: 10.1136/gut.30.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vena J. E., Graham S., Zielezny M., Swanson M. K., Barnes R. E., Nolan J. Lifetime occupational exercise and colon cancer. Am J Epidemiol. 1985 Sep;122(3):357–365. doi: 10.1093/oxfordjournals.aje.a114116. [DOI] [PubMed] [Google Scholar]
- Wu A. H., Paganini-Hill A., Ross R. K., Henderson B. E. Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study. Br J Cancer. 1987 Jun;55(6):687–694. doi: 10.1038/bjc.1987.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wyman J. B., Heaton K. W., Manning A. P., Wicks A. C. Variability of colonic function in healthy subjects. Gut. 1978 Feb;19(2):146–150. doi: 10.1136/gut.19.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]