Skip to main content
PMC home page
Gut logoLink to Gut
. 1992 Sep;33(9):1170–1173. doi: 10.1136/gut.33.9.1170

Effect of acute cigarette smoking on gastric secretion.

J C Roxburgh 1, P F Whitfield 1, M Hobsley 1
PMCID: PMC1379480  PMID: 1427367

Abstract

The effects of smoking one cigarette on a plateau of submaximal gastric secretion induced by histamine acid phosphate (16 nmol kg-1 h-1 (0.005 mg kg-1 h-1)) were measured in eight normal volunteers and in eight duodenal ulcer subjects. The rate of secretion in both groups fell by 25% without any statistically significant change in pyloric loss or duodenogastric reflux. It is concluded that smoking reduces gastric secretion. The possibility that relative antral hypoacidity induced by regular smoking produces an increase in parietal cell mass via a feedback mechanism mediated by gastrin is discussed: such a mechanism would explain the previously reported positive correlation between maximal gastric secretion of acid and the total dose of cigarettes.

Full text

PDF
1172

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armitage A. K., Dollery C. T., George C. F., Houseman T. H., Lewis P. J., Turner D. M. Absorption and metabolism of nicotine from cigarettes. Br Med J. 1975 Nov 8;4(5992):313–316. doi: 10.1136/bmj.4.5992.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ashton A., Telford R. Letter: Blood carboxyhaemoglobin levels in smokers. Br Med J. 1973 Dec 22;4(5894):740–740. doi: 10.1136/bmj.4.5894.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aubrey D. A. The effects on human gastric secretion of prolonged continuous intravenous infusions of maximal and supramaximal doses of histamine acid phosphate and pentagastrin. Gut. 1970 May;11(5):392–394. doi: 10.1136/gut.11.5.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brandsborg O., Christensen N. J., Galbo H., Brandsborg M., Løvgreen N. A. The effect of exercise, smoking and propranolol on serum gastrin in patients with duodenal ulcer and in vagotomized subjects. Scand J Clin Lab Invest. 1978 Sep;38(5):441–446. doi: 10.1080/00365517809108449. [DOI] [PubMed] [Google Scholar]
  5. Cohen M. M., Debas H. T., Holubitsky I. B., Harrison R. C. Effect of nausea on human gastric secretory responses. Am J Dig Dis. 1971 Feb;16(2):156–159. doi: 10.1007/BF02284455. [DOI] [PubMed] [Google Scholar]
  6. Crean G. P., Marshall M. W., Rumsey R. D. Parietal cell hyperplasia induced by the administration of pentagastrin (ICI 50,123) to rats. Gastroenterology. 1969 Aug;57(2):147–155. [PubMed] [Google Scholar]
  7. Debas H. T., Cohen M. M. Effect of smoking on gastric secretion stimulated by pentagastrin. Lancet. 1972 Jan 1;1(7740):43–44. doi: 10.1016/s0140-6736(72)90039-6. [DOI] [PubMed] [Google Scholar]
  8. Feurle G. E. Effect of rising intragastric pH induced by several antacids on serum gastrin concentrations in duodenal ulcer patients and in a control group. Gastroenterology. 1975 Jan;68(1):1–7. [PubMed] [Google Scholar]
  9. Fletcher D. R., Shulkes A., Hardy K. J. The effect of cigarette smoking on gastric acid secretion and gastric mucosal blood flow in man. Aust N Z J Med. 1985 Aug;15(4):417–420. doi: 10.1111/j.1445-5994.1985.tb02763.x. [DOI] [PubMed] [Google Scholar]
  10. Fung W. P., Tye C. Y. Effect of smoking on gastric acid secretion. Aust N Z J Med. 1973 Jun;3(3):251–254. doi: 10.1111/j.1445-5994.1973.tb03090.x. [DOI] [PubMed] [Google Scholar]
  11. Helander H. F. Parietal cell structure during inhibition of acid secretion. Scand J Gastroenterol Suppl. 1984;101:21–26. [PubMed] [Google Scholar]
  12. Hersey S. J., Chew C. S., Campbell L., Hopkins E. Mechanism of action of SCN in isolated gastric glands. Am J Physiol. 1981 Mar;240(3):G232–G238. doi: 10.1152/ajpgi.1981.240.3.G232. [DOI] [PubMed] [Google Scholar]
  13. Häkanson R., Hedenbro J., Liedberg G., Rehfeld J. F., Stadil F. Activation of histidine decarboxylase by H2-receptor blockade: mechanism of action. Br J Pharmacol. 1975 Jan;53(1):127–130. doi: 10.1111/j.1476-5381.1975.tb07339.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Isaac P. F., Rand M. J. Cigarette smoking and plasma levels of nicotine. Nature. 1972 Apr 7;236(5345):308–310. doi: 10.1038/236308a0. [DOI] [PubMed] [Google Scholar]
  15. Johnson L. R. The trophic action of gastrointestinal hormones. Gastroenterology. 1976 Feb;70(2):278–288. [PubMed] [Google Scholar]
  16. Massarrat S., Enschai F., Pittner P. M. Increased gastric secretory capacity in smokers without gastrointestinal lesions. Gut. 1986 Apr;27(4):433–439. doi: 10.1136/gut.27.4.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Parente F., Lazzaroni M., Sangaletti O., Baroni S., Bianchi Porro G. Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients. Gut. 1985 Dec;26(12):1327–1332. doi: 10.1136/gut.26.12.1327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sonnenberg A., Hüsmert N. Effect of nicotine on gastric mucosal blood flow and acid secretion. Gut. 1982 Jun;23(6):532–535. doi: 10.1136/gut.23.6.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sundler F., Håkanson R., Carlsson E., Larsson H., Mattsson H. Hypergastrinemia after blockade of acid secretion in the rat: trophic effects. Digestion. 1986;35 (Suppl 1):56–69. doi: 10.1159/000199382. [DOI] [PubMed] [Google Scholar]
  20. Thompson J. H., Angulo M. Chronic effects of nicotine on gastric secretion in vagotomized rats. Experientia. 1971 Apr 15;27(4):404–405. doi: 10.1007/BF02137276. [DOI] [PubMed] [Google Scholar]
  21. Whitecross D. P., Clarke A. D., Piper D. W. The effect of cigarette smoking on human gastric secretion. Scand J Gastroenterol. 1974;9(4):399–403. [PubMed] [Google Scholar]
  22. Whitfield P. F., Hobsley M. A standardized technique for the performance of accurate gastric secretion studies. Agents Actions. 1979 Oct;9(4):327–332. doi: 10.1007/BF01970656. [DOI] [PubMed] [Google Scholar]
  23. Whitfield P. F., Hobsley M. Comparison of maximal gastric secretion in smokers and non-smokers with and without duodenal ulcer. Gut. 1987 May;28(5):557–560. doi: 10.1136/gut.28.5.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wilkinson A. R., Johnston D. Inhibitory effect of cigarette smoking on gastric secretion stimulated by pentagastrin in man. Lancet. 1971 Sep 18;2(7725):628–632. doi: 10.1016/s0140-6736(71)80070-3. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES