Skip to main content
PMC home page
Gut logoLink to Gut
. 1992 Nov;33(11):1477–1481. doi: 10.1136/gut.33.11.1477

Gastric antral dysrhythmias in children with chronic idiopathic intestinal pseudoobstruction.

S P Devane 1, A M Ravelli 1, W M Bisset 1, V V Smith 1, B D Lake 1, P J Milla 1
PMCID: PMC1379531  PMID: 1452071

Abstract

Chronic idiopathic intestinal pseudoobstruction is a serious disorder of intestinal neuromuscular function resulting in recurrent episodes of intestinal obstruction, and is caused by primary disease of the enteric nerves or enteric smooth muscle. Gastric electrical control activity detected by the non-invasive technique of surface electrogastrography was investigated in 11 children (0.1-16 years) with proven chronic idiopathic intestinal pseudoobstruction (four with known disease of the enteric nerves, three with disease of smooth muscle cells, and four without defined pathology), to determine whether abnormalities were present and whether these were useful in detecting the underlying pathology. Abnormalities were present in eight of 11 patients. Persistent tachygastria (electrical control activity frequency > 5 cycles/minute) was found in three patients, all with a proven neuropathy. A continuously irregular frequency was found in five patients, three with a proven myopathy and two with undefined pathology. A normal electrical control activity frequency was present in three patients, one with a proven neuropathy and two with undefined pathology. It is suggested that this non-invasive technique may provide a useful screening test of the pathophysiological basis of the functional obstruction in children with chronic idiopathic intestinal pseudoobstruction.

Full text

PDF
1477

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abell T. L., Malagelada J. R. Glucagon-evoked gastric dysrhythmias in humans shown by an improved electrogastrographic technique. Gastroenterology. 1985 Jun;88(6):1932–1940. doi: 10.1016/0016-5085(85)90022-8. [DOI] [PubMed] [Google Scholar]
  2. Abell T. L., Malagelada J. R., Lucas A. R., Brown M. L., Camilleri M., Go V. L., Azpiroz F., Callaway C. W., Kao P. C., Zinsmeister A. R. Gastric electromechanical and neurohormonal function in anorexia nervosa. Gastroenterology. 1987 Nov;93(5):958–965. doi: 10.1016/0016-5085(87)90557-9. [DOI] [PubMed] [Google Scholar]
  3. Blank E. L., Karaus M., Glicklich M., Sarna S. K., Werlin S. L. Gastrointestinal myoelectric activity in an infant with congenital idiopathic motility disorder. Dig Dis Sci. 1989 Jul;34(7):1124–1131. doi: 10.1007/BF01536386. [DOI] [PubMed] [Google Scholar]
  4. Cucchiara S., Janssens J., Vantrappen G., Geboes K., Ceccatelli P. Gastric electrical dysrhythmias (tachygastria and tachyarrhythmia) in a girl with chronic intractable vomiting. J Pediatr. 1986 Feb;108(2):264–267. doi: 10.1016/s0022-3476(86)81001-0. [DOI] [PubMed] [Google Scholar]
  5. Fenton T. R., Harries J. T., Milla P. J. Disordered small intestinal motility: a rational basis for toddlers' diarrhoea. Gut. 1983 Oct;24(10):897–903. doi: 10.1136/gut.24.10.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Geldof H., van der Schee E. J., van Blankenstein M., Grashuis J. L. Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting. Gut. 1986 Jul;27(7):799–808. doi: 10.1136/gut.27.7.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Geldof H., van der Schee E. J., van Blankenstein M., Smout A. J., Akkermans L. M. Effects of highly selective vagotomy on gastric myoelectrical activity. An electrogastrographic study. Dig Dis Sci. 1990 Aug;35(8):969–975. doi: 10.1007/BF01537245. [DOI] [PubMed] [Google Scholar]
  8. Hamilton J. W., Bellahsene B. E., Reichelderfer M., Webster J. G., Bass P. Human electrogastrograms. Comparison of surface and mucosal recordings. Dig Dis Sci. 1986 Jan;31(1):33–39. doi: 10.1007/BF01347907. [DOI] [PubMed] [Google Scholar]
  9. Hyman P. E., McDiarmid S. V., Napolitano J., Abrams C. E., Tomomasa T. Antroduodenal motility in children with chronic intestinal pseudo-obstruction. J Pediatr. 1988 Jun;112(6):899–905. doi: 10.1016/s0022-3476(88)80211-7. [DOI] [PubMed] [Google Scholar]
  10. Kelly K. A. Differential responses of the canine gastric corpus and antrum to electric stimulation. Am J Physiol. 1974 Jan;226(1):230–234. doi: 10.1152/ajplegacy.1974.226.1.230. [DOI] [PubMed] [Google Scholar]
  11. Krishnamurthy S., Schuffler M. D. Pathology of neuromuscular disorders of the small intestine and colon. Gastroenterology. 1987 Sep;93(3):610–639. doi: 10.1016/0016-5085(87)90926-7. [DOI] [PubMed] [Google Scholar]
  12. Navarro J., Sonsino E., Boige N., Nabarra B., Ferkadji L., Mashako L. M., Cezard J. P. Visceral neuropathies responsible for chronic intestinal pseudo-obstruction syndrome in pediatric practice: analysis of 26 cases. J Pediatr Gastroenterol Nutr. 1990 Aug;11(2):179–195. doi: 10.1097/00005176-199008000-00006. [DOI] [PubMed] [Google Scholar]
  13. Nelsen T. S., Kohatsu S. Clinical electrogastrography and its relationship to gastric surgery. Am J Surg. 1968 Aug;116(2):215–222. doi: 10.1016/0002-9610(68)90496-0. [DOI] [PubMed] [Google Scholar]
  14. Stanghellini V., Camilleri M., Malagelada J. R. Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings. Gut. 1987 Jan;28(1):5–12. doi: 10.1136/gut.28.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Telander R. L., Morgan K. G., Kreulen D. L., Schmalz P. F., Kelly K. A., Szurszewski J. H. Human gastric atony with tachygastria and gastric retention. Gastroenterology. 1978 Sep;75(3):497–501. [PubMed] [Google Scholar]
  16. van der Schee E. J., Grashuis J. L. Running spectrum analysis as an aid in the representation and interpretation of electrogastrographic signals. Med Biol Eng Comput. 1987 Jan;25(1):57–62. doi: 10.1007/BF02442821. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES