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. 1992 Dec;33(12):1617–1620. doi: 10.1136/gut.33.12.1617

Concentrations of metals in gastric juice in health and peptic ulcer disease.

J J Powell 1, S M Greenfield 1, R P Thompson 1
PMCID: PMC1379571  PMID: 1487162

Abstract

The concentrations of essential metal cations in gastric juice, collected at endoscopy from 17 normal patients and 11 with peptic ulcer disease, were determined by inductively coupled plasma emission spectrometry. Mean fasting levels in normal gastric juice were as follows: sodium 47.7 mM, potassium 14.6 mM, calcium 0.8 mM, magnesium 0.36 mM, zinc 13 microM, and copper 1.2 microM: these did not differ significantly in health or disease. Because samples were contaminated with iron, the concentration of this metal was only estimated (ca 3.5 microM in normal subjects), and this secretion could represent a significant proportion of the daily loss of endogenous iron. The pH of gastric juice predicted the concentrations of magnesium and calcium, but not copper or zinc, in the juice. It is concluded that previously reported values for trace metals in gastric juice have been incorrect and that the very low amounts secreted in the gastric juice will not interfere with the absorption of other trace metals from the diet. In contrast, the concentrations of macroelements in gastric juice may be sufficient to stimulate the absorption of trace metals from the gut.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bales C. W., Freeland-Graves J. H., Askey S., Behmardi F., Pobocik R. S., Fickel J. J., Greenlee P. Zinc, magnesium, copper, and protein concentrations in human saliva: age- and sex-related differences. Am J Clin Nutr. 1990 Mar;51(3):462–469. doi: 10.1093/ajcn/51.3.462. [DOI] [PubMed] [Google Scholar]
  2. Coleman J. R., Young L. B. Metal binding by intestinal mucus. Scan Electron Microsc. 1979;(2):801–806. [PubMed] [Google Scholar]
  3. Conrad M. E., Umbreit J. N., Moore E. G. A role for mucin in the absorption of inorganic iron and other metal cations. A study in rats. Gastroenterology. 1991 Jan;100(1):129–136. doi: 10.1016/0016-5085(91)90592-9. [DOI] [PubMed] [Google Scholar]
  4. Crowther R. S., Marriott C. Counter-ion binding to mucus glycoproteins. J Pharm Pharmacol. 1984 Jan;36(1):21–26. doi: 10.1111/j.2042-7158.1984.tb02980.x. [DOI] [PubMed] [Google Scholar]
  5. Escolar G., Bulbena O. Zinc compounds, a new treatment in peptic ulcer. Drugs Exp Clin Res. 1989;15(2):83–89. [PubMed] [Google Scholar]
  6. Flanagan P. R. Trace metal interactions involving the intestinal absorption mechanisms of iron and zinc. Adv Exp Med Biol. 1989;249:35–44. doi: 10.1007/978-1-4684-9111-1_4. [DOI] [PubMed] [Google Scholar]
  7. Gollan J. L., Davis P. S., Deller D. J. Copper content of human alimentary secretions. Clin Biochem. 1971 Apr;4(1):42–44. doi: 10.1016/s0009-9120(71)90423-1. [DOI] [PubMed] [Google Scholar]
  8. Greger J. L., Sickles V. S. Saliva zinc levels: potential indicators of zinc status. Am J Clin Nutr. 1979 Sep;32(9):1859–1866. doi: 10.1093/ajcn/32.9.1859. [DOI] [PubMed] [Google Scholar]
  9. Ishihara N., Matsushiro T. Biliary and urinary excretion of metals in humans. Arch Environ Health. 1986 Sep-Oct;41(5):324–330. doi: 10.1080/00039896.1986.9936705. [DOI] [PubMed] [Google Scholar]
  10. Kimura I., Yamana M., Onoshi T., Nishizaki Y. [The iron content of the gastric juice: in relation to the cause of idiopathic hypochromic anemia]. Nihon Ketsueki Gakkai Zasshi. 1968 Apr;31(2):199–203. [PubMed] [Google Scholar]
  11. MOORE E. W., SCARLATA R. W. THE DETERMINATION OF GASTRIC ACIDITY BY THE GLASS ELECTRODE. Gastroenterology. 1965 Aug;49:178–188. [PubMed] [Google Scholar]
  12. Makhlouf G. M., McManus J. P., Card W. I. A quantitative statement of the two-component hypothesis of gastric secretion. Gastroenterology. 1966 Aug;51(2):149–171. [PubMed] [Google Scholar]
  13. Malinowska D. H., Sachs G. Cellular mechanisms of acid secretion. Clin Gastroenterol. 1984 May;13(2):309–326. [PubMed] [Google Scholar]
  14. Moore E. W. Determination of pH by the glass electrode: pH meter calibration for gastric analysis. Gastroenterology. 1968 Apr;54(4):501–507. [PubMed] [Google Scholar]
  15. Rossander-Hultén L., Brune M., Sandström B., Lönnerdal B., Hallberg L. Competitive inhibition of iron absorption by manganese and zinc in humans. Am J Clin Nutr. 1991 Jul;54(1):152–156. doi: 10.1093/ajcn/54.1.152. [DOI] [PubMed] [Google Scholar]
  16. Rudzki Z., Baker R. J., Deller D. J. The iron-binding glycoprotein of human gastric juice. II. Nature of the interaction of the glycoprotein with iron. Digestion. 1973;8(1):53–67. doi: 10.1159/000197300. [DOI] [PubMed] [Google Scholar]

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