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. 1989 Apr;27(4):499–505. doi: 10.1111/j.1365-2125.1989.tb05399.x

The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers.

P J Hoskin 1, G W Hanks 1, G W Aherne 1, D Chapman 1, P Littleton 1, J Filshie 1
PMCID: PMC1379730  PMID: 2719903

Abstract

1. The absolute bioavailability of morphine from oral aqueous solution, a controlled release oral tablet (MST-Continus) and a controlled release buccal tablet has been investigated in six healthy volunteers. 2. Analysis of plasma samples for morphine and its active metabolite morphine-6-glucuronide (M6G) was by means of a differential radioimmunoassay technique. Absolute bioavailability for morphine was estimated to be 23.9% after oral solution, 22.4% after MST-Continus and 18.7% after the buccal tablet. Maximum plasma morphine concentrations were seen at 45 min (oral solution), 2.5 h (MST) and 6 h (buccal). 3. There was no difference in the amount of M6G appearing in plasma after intravenous, oral or buccal administration but the mean ratio of AUCs for M6G: morphine in plasma after intravenous morphine was 2 : 1 compared with 11 : 1 after oral and buccal morphine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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