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. 1989 May;27(5):607–611. doi: 10.1111/j.1365-2125.1989.tb03423.x

Comparative analgesic and anti-inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis.

S J Preston 1, M H Arnold 1, E M Beller 1, P M Brooks 1, W W Buchanan 1
PMCID: PMC1379926  PMID: 2788004

Abstract

1. Enteric coated sodium salicylate 4.8 g daily was compared with the same dose of enteric coated aspirin in 18 patients with rheumatoid arthritis. 2. After an initial washout period lasting 3 days, patients were randomly allocated to treatment with sodium salicylate or aspirin. After 2 weeks the two treatments were crossed over. 3. Pain relief, reduction in articular index of joint tenderness, increase in grip strength, decrease in digital joint circumference and patients' assessment showed significant improvement with both treatments compared with the washout period. No significant differences were found between the two therapies. 4. No correlation was found in the degree of improvement in any of the clinical outcomes and the salicylate concentrations at steady state.

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Selected References

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  1. Blechman W. J., Lechner B. L. Clinical comparative evaluation of choline magnesium trisalicylate and acetylsalicylic acid in rheumatoid arthritis. Rheumatol Rehabil. 1979 May;18(2):119–124. doi: 10.1093/rheumatology/18.2.119. [DOI] [PubMed] [Google Scholar]
  2. Brogden R. N., Heel R. C., Pakes G. E., Speight T. M., Avery G. S. Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. Drugs. 1980 Feb;19(2):84–106. doi: 10.2165/00003495-198019020-00002. [DOI] [PubMed] [Google Scholar]
  3. Brooks P. M., Walker J. J., Dick W. C. Phenylbutazone: a clinico-pharmacological study in rheumatoid arthritis. Br J Clin Pharmacol. 1975 Oct;2(5):437–442. doi: 10.1111/j.1365-2125.1975.tb00553.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Calabro J. J., Paulus H. E. Anti-inflammatory effect of acetylsalicylic acid in rheumatoid arthritis. Clin Orthop Relat Res. 1970;71:124–131. [PubMed] [Google Scholar]
  5. Clive D. M., Stoff J. S. Renal syndromes associated with nonsteroidal antiinflammatory drugs. N Engl J Med. 1984 Mar 1;310(9):563–572. doi: 10.1056/NEJM198403013100905. [DOI] [PubMed] [Google Scholar]
  6. Crook D., Collins A. J., Bacon P. A., Chan R. Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy. Ann Rheum Dis. 1976 Aug;35(4):327–332. doi: 10.1136/ard.35.4.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Day R. O., Furst D. E., Dromgoole S. H., Kamm B., Roe R., Paulus H. E. Relationship of serum naproxen concentration to efficacy in rheumatoid arthritis. Clin Pharmacol Ther. 1982 Jun;31(6):733–740. doi: 10.1038/clpt.1982.103. [DOI] [PubMed] [Google Scholar]
  8. DeSchepper P. J., Tjandramaga T. B., De Roo M., Verhaest L., Daurio C., Steelman S. L., Tempero K. F. Gastrointestinal blood loss after diflunisal and after aspirin: effect of ethanol. Clin Pharmacol Ther. 1978 Jun;23(6):669–676. doi: 10.1002/cpt1978236669. [DOI] [PubMed] [Google Scholar]
  9. Deodhar S. D., Dick W. C., Hodgkinson R., Buchanan W. W. Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis. Q J Med. 1973 Apr;42(166):387–401. [PubMed] [Google Scholar]
  10. Dunagan F. M., McGill P. E., Kelman A. W., Whiting B. Quantitation of dose and concentration-effect relationships for fenclofenac in rheumatoid arthritis. Br J Clin Pharmacol. 1986 Apr;21(4):409–416. doi: 10.1111/j.1365-2125.1986.tb05215.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ekstrand R., Alván G., L'e Orme M., Lewander R., Palmér L., Sarby B. Double-blind dose-response study of indomethacin in rheumatoid arthritis. Eur J Clin Pharmacol. 1980 Jun;17(6):437–442. doi: 10.1007/BF00570161. [DOI] [PubMed] [Google Scholar]
  12. Essigman W. K., Chamberlain M. A., Wright V. Diflunisal in osteoarthrosis of the hip and knee. Ann Rheum Dis. 1979 Apr;38(2):148–151. doi: 10.1136/ard.38.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Graham G. G., Champion G. D., Day R. O., Paull P. D. Patterns of plasma concentrations and urinary excretion of salicylate in rheumatoid arthritis. Clin Pharmacol Ther. 1977 Oct;22(4):410–420. doi: 10.1002/cpt1977224410. [DOI] [PubMed] [Google Scholar]
  14. Gurwich E. L., Raees S. M., Skosey J., Niazi S. Unbound plasma salicylate concentration in rheumatoid arthritis patients. Br J Rheumatol. 1984 Feb;23(1):66–73. doi: 10.1093/rheumatology/23.1.66. [DOI] [PubMed] [Google Scholar]
  15. LASAGNA L. Analgesic drugs. Am J Med Sci. 1961 Nov;242:620–627. doi: 10.1097/00000441-196111000-00013. [DOI] [PubMed] [Google Scholar]
  16. Lee P., Baxter A., Dick W. C., Webb J. An assessment of grip strength measurement in rheumatoid arthritis. Scand J Rheumatol. 1974;3(1):17–23. doi: 10.3109/03009747409165124. [DOI] [PubMed] [Google Scholar]
  17. Leonards J. R., Levy G. Gastrointestinal blood loss from aspirin and sodium salicylate tablets in man. Clin Pharmacol Ther. 1973 Jan-Feb;14(1):62–66. doi: 10.1002/cpt197314162. [DOI] [PubMed] [Google Scholar]
  18. Levy G. Aspirin, absorption rate and analgesic effect. Anesth Analg. 1965 Nov-Dec;44(6):837–841. [PubMed] [Google Scholar]
  19. Liyanage S. P., Tambar P. K. Comparative study of salsalate and aspirin in osteoarthrosis of the hip or knee. Curr Med Res Opin. 1978;5(6):450–453. doi: 10.1185/03007997809111914. [DOI] [PubMed] [Google Scholar]
  20. Mitchell K. G., Hearns J., Crean G. P. The effect of the non-steroidal anti-inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation. Br J Clin Pharmacol. 1984 Jan;17(1):27–30. doi: 10.1111/j.1365-2125.1984.tb04994.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Orme M., Holt P. J., Hughes G. R., Bulpitt C. J., Draffan G. H., Thorgeirsson S. S., Williams F., Davies D. S. Plasma concentration of phenylbutazone and its therapeutic effect-studies in patients with rheumatoid arthritis. Br J Clin Pharmacol. 1976 Feb;3(1):185–191. doi: 10.1111/j.1365-2125.1976.tb00587.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. PIERSON R. N., Jr, HOLT P. R., WATSON R. M., KEATING R. P. Aspirin and gastrointestinal bleeding. Chromate blood loss studies. Am J Med. 1961 Aug;31:259–265. doi: 10.1016/0002-9343(61)90114-0. [DOI] [PubMed] [Google Scholar]
  23. Paulus H. E., Siegel M., Mongan E., Okun R., Calabro J. J. Variations of serum concentrations and half-life of salicylate in patients with rheumatoid arthritis. Arthritis Rheum. 1971 Jul-Aug;14(4):527–532. doi: 10.1002/art.1780140412. [DOI] [PubMed] [Google Scholar]
  24. Pinckard R. N., Hawkins D., Farr R. S. In vitro acetylation of plasma proteins, enzymes and DNA by aspirin. Nature. 1968 Jul 6;219(5149):68–69. doi: 10.1038/219068a0. [DOI] [PubMed] [Google Scholar]
  25. Pinckard R. N., Hawkins D., Farr R. S. The inhibitory effect of salicylate on the acetylation of human albumin by acetylsalicylic acid. Arthritis Rheum. 1970 Jul-Aug;13(4):361–368. doi: 10.1002/art.1780130401. [DOI] [PubMed] [Google Scholar]
  26. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  27. Rich R. R., Johnson J. S. Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis. Arthritis Rheum. 1973 Jan-Feb;16(1):1–9. doi: 10.1002/art.1780160102. [DOI] [PubMed] [Google Scholar]
  28. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  29. SEED J. C. A CLINICAL COMPARISON OF THE ANTIPYRETIC POTENCY OF ASPIRIN AND SODIUM SALICYLATE. Clin Pharmacol Ther. 1965 May-Jun;6:354–358. doi: 10.1002/cpt196563354. [DOI] [PubMed] [Google Scholar]
  30. Samter M., Beers R. F., Jr Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med. 1968 May;68(5):975–983. doi: 10.7326/0003-4819-68-5-975. [DOI] [PubMed] [Google Scholar]
  31. Szczeklik A., Gryglewski R. J., Czerniawska-Mysik G. Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. Br Med J. 1975 Jan 11;1(5949):67–69. doi: 10.1136/bmj.1.5949.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. TRINDER P. Rapid determination of salicylate in biological fluids. Biochem J. 1954 Jun;57(2):301–303. doi: 10.1042/bj0570301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Webb J., Downie W. W., Dick W. C., Lee P. Evaluation of digital joint circumference measurements in rheumatoid arthritis. Scand J Rheumatol. 1973;2(3):127–131. doi: 10.3109/03009747309098831. [DOI] [PubMed] [Google Scholar]

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