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. 1989 Oct;28(4):415–420. doi: 10.1111/j.1365-2125.1989.tb03521.x

Lisinopril dose-response relationship in essential hypertension

H J Gomez, V J Cirillo, J A Sromovsky, E S Otterbein, W C Shaw, J E Rush, S G Chrysant, A H Gradman, A S Leon, E P MacCarthy, E B Nelson, J Pool, A Vedin
PMCID: PMC1379991  PMID: 2556172

Abstract

1 This was a multicentre, double-blind, parallel study in 216 patients with mild to moderate (supine diastolic blood pressure = 95-115 mm Hg) essential hypertension.

2 After a 4-week placebo washout, patients were randomized to placebo or lisinopril 1.25, 5, 20 or 80 mg once daily for 6 consecutive weeks. Supine and erect blood pressure was measured 24 h postdose at the end of weeks -2, 0, 2, 4, and 6.

3 There was a linear dose-response relationship for both supine and erect blood pressure. Diastolic blood pressure reductions in the lisinopril 20 and 80 mg day-1 groups were significantly greater than in the placebo or lisinopril 1.25 and 5 mg day-1 groups.

4 Lisinopril, at doses up to 80 mg day-1, was well tolerated.

Keywords: lisinopril, angiotensin converting enzyme inhibitor, hypertension, dose-response relationship

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Selected References

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