Abstract
1. The respiratory and psychomotor effects of two benzodiazepines used mainly as anticonvulsants were compared in healthy volunteers, using a double-blind placebo controlled design. 2. Clobazam (10 and 20 mg) produced significantly fewer psychomotor side effects than clonazepam (0.5 and 1 mg). Neither drug at either dose affected the ventilatory response to CO2. 3. Although clonazepam produced significant effects on psychomotor performance, these did not correlate with plasma drug concentration. 4. Our studies provide further evidence that at the doses chosen clobazam is considerably less sedating than clonazepam. Further investigation is required into the tolerance profile of both drugs in patients.
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Selected References
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- Badcock N. R., Pollard A. C. Micro-determination of clonazepam in plasma or serum by electron-capture gas-liquid chromatography. J Chromatogr. 1982 Jul 9;230(2):353–361. doi: 10.1016/s0378-4347(00)80485-5. [DOI] [PubMed] [Google Scholar]
- Caccia S., Ballabio M., Guiso G., Zanini M. G. Gas-liquid chromatographic determination of clobazam and n-desmethyl-clobazam in plasma. J Chromatogr. 1979 Sep 11;164(1):100–105. [PubMed] [Google Scholar]
- Congdon P. J., Forsythe W. I. Intravenous clonazepam in the treatment of status epilepticus in children. Epilepsia. 1980 Feb;21(1):97–102. doi: 10.1111/j.1528-1157.1980.tb04049.x. [DOI] [PubMed] [Google Scholar]
- Crawford T. O., Mitchell W. G., Snodgrass S. R. Lorazepam in childhood status epilepticus and serial seizures: effectiveness and tachyphylaxis. Neurology. 1987 Feb;37(2):190–195. doi: 10.1212/wnl.37.2.190. [DOI] [PubMed] [Google Scholar]
- Greenblatt D. J. Electron-capture GLC determination of clobazam and desmethylclobazam in plasma. J Pharm Sci. 1980 Nov;69(11):1351–1352. doi: 10.1002/jps.2600691131. [DOI] [PubMed] [Google Scholar]
- Hindmarch I. Some aspects of the effects of clobazam on human psychomotor performance. Br J Clin Pharmacol. 1979;7 (Suppl 1):77S–82S. doi: 10.1111/j.1365-2125.1979.tb04669.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Patat A., Foulhoux P. Effect on postural sway of various benzodiazepine tranquillizers. Br J Clin Pharmacol. 1985 Jul;20(1):9–16. doi: 10.1111/j.1365-2125.1985.tb02792.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pleuvry B. J., Maddison S. E., Odeh R. B., Dodson M. E. Respiratory and psychological effects of oral temazepam in volunteers. Br J Anaesth. 1980 Sep;52(9):901–906. doi: 10.1093/bja/52.9.901. [DOI] [PubMed] [Google Scholar]
- Pullar T., Haigh J. R., Peaker S., Feely M. P. Pharmacokinetics of N-desmethylclobazam in healthy volunteers and patients with epilepsy. Br J Clin Pharmacol. 1987 Dec;24(6):793–797. doi: 10.1111/j.1365-2125.1987.tb03247.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Read D. J. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med. 1967 Feb;16(1):20–32. doi: 10.1111/imj.1967.16.1.20. [DOI] [PubMed] [Google Scholar]
- Rudolf M., Geddes D. M., Turner J. A., Saunders K. B. Depression of central respiratory drive by nitrazepam. Thorax. 1978 Feb;33(1):97–100. doi: 10.1136/thx.33.1.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Utting H. J., Pleuvry B. J. Benzoctamine-a study of the respiratory effects of oral doses in human volunteers and interactions with morphine in mice. Br J Anaesth. 1975 Sep;47(9):987–992. doi: 10.1093/bja/47.9.987. [DOI] [PubMed] [Google Scholar]