Abstract
The effects of a single oral dose of 25 mg carvedilol on the plasma and urinary kinetics of digoxin after an oral and intravenous 0.5 mg dose, were investigated in two separate double-blind, placebo-controlled, period-balanced cross-over studies in healthy male subjects. Carvedilol increased the mean maximum plasma concentration and the area under the plasma concentration time-curve of digoxin when administered orally. The effects were virtually confined to the first 4 h after dosing, and the apparent terminal disposition rate constant was not changed. Carvedilol did not alter the plasma and urinary kinetics of intravenously administered digoxin.
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Selected References
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- Bertler A., Bergdahl B., Karlsson E. Letter: Plasma-digoxin concentrations after an intravenous loading dose. Lancet. 1974 Oct 19;2(7886):958–958. doi: 10.1016/s0140-6736(74)91168-4. [DOI] [PubMed] [Google Scholar]
- Cubeddu L. X., Fuenmayor N., Varin F., Villagra V. G., Colindres R. E., Powell J. R. Clinical pharmacology of carvedilol in normal volunteers. Clin Pharmacol Ther. 1987 Jan;41(1):31–44. doi: 10.1038/clpt.1987.6. [DOI] [PubMed] [Google Scholar]
- Meineke I. A simple BASIC program for the calculation of nonparametric confidence intervals in bioequivalence testing. Comput Methods Programs Biomed. 1987 Feb;24(1):65–71. doi: 10.1016/0169-2607(87)90067-8. [DOI] [PubMed] [Google Scholar]
- Rodin S. M., Johnson B. F. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet. 1988 Oct;15(4):227–244. doi: 10.2165/00003088-198815040-00003. [DOI] [PubMed] [Google Scholar]
- Sponer G., Bartsch W., Strein K., Müller-Beckmann B., Böhm E. Pharmacological profile of carvedilol as a beta-blocking agent with vasodilating and hypotensive properties. J Cardiovasc Pharmacol. 1987 Mar;9(3):317–327. doi: 10.1097/00005344-198703000-00009. [DOI] [PubMed] [Google Scholar]
- Steinijans V. W., Diletti E. Generalization of distribution--free confidence intervals for bioavailability ratios. Eur J Clin Pharmacol. 1985;28(1):85–88. doi: 10.1007/BF00635713. [DOI] [PubMed] [Google Scholar]