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. 1990 Mar;29(3):355–358. doi: 10.1111/j.1365-2125.1990.tb03647.x

Single doses of ritodrine delay orocaecal transit in patients with irritable bowel syndrome.

G Basilisco 1, M G Camboni 1, A Bozzani 1, M Molgora 1, P A Bianchi 1
PMCID: PMC1380137  PMID: 2310659

Abstract

The lactulose hydrogen breath test was used to assess the effect of a single dose of the beta 2-adrenoceptor agonist ritodrine on orocaecal transit time in 11 patients (three men) with irritable bowel syndrome. Transit time (median values, range) was significantly longer (P less than 0.01) after ritodrine than after placebo (120, 50-200 vs 75, 40-100 min). Median heart rate was similar before treatments whereas the maximal increase in heart rate was significantly greater (P less than 0.01) after ritodrine than after placebo.

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Selected References

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  1. Basilisco G., Camboni G., Bozzani A., Paravicini M., Bianchi P. A. Oral naloxone antagonizes loperamide-induced delay of orocecal transit. Dig Dis Sci. 1987 Aug;32(8):829–832. doi: 10.1007/BF01296704. [DOI] [PubMed] [Google Scholar]
  2. Camboni G., Basilisco G., Bozzani A., Bianchi P. A. Repeatability of lactulose hydrogen breath test in subjects with normal or prolonged orocecal transit. Dig Dis Sci. 1988 Dec;33(12):1525–1527. doi: 10.1007/BF01535941. [DOI] [PubMed] [Google Scholar]
  3. Cann P. A., Read N. W., Brown C., Hobson N., Holdsworth C. D. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut. 1983 May;24(5):405–411. doi: 10.1136/gut.24.5.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cann P. A., Read N. W., Holdsworth C. D. What is the benefit of coarse wheat bran in patients with irritable bowel syndrome? Gut. 1984 Feb;25(2):168–173. doi: 10.1136/gut.25.2.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Caritis S. N., Toig G., Heddinger L. A., Ashmead G. A double-blind study comparing ritodrine and terbutaline in the treatment of preterm labor. Am J Obstet Gynecol. 1984 Sep 1;150(1):7–14. doi: 10.1016/s0002-9378(84)80101-5. [DOI] [PubMed] [Google Scholar]
  6. Ek B. A., Bjellin L. A., Lundgren B. T. Beta-adrenergic control of motility in the rat colon. I. Evidence for functional separation of the beta 1- and beta 2-adrenoceptor-mediated inhibition of colon activity. Gastroenterology. 1986 Feb;90(2):400–407. doi: 10.1016/0016-5085(86)90939-x. [DOI] [PubMed] [Google Scholar]
  7. Fielding J. F., Regan R. Excessive cold pressor responses in the irritable bowel syndrome. Ir J Med Sci. 1984 Oct;153(10):348–350. doi: 10.1007/BF02939930. [DOI] [PubMed] [Google Scholar]
  8. Giudice A., Croci T., Bianchetti A., Manara L. Inhibition of rat colonic motility and cardiovascular effects of new gut-specific beta-adrenergic phenylethanolaminotetralines. Life Sci. 1989;44(19):1411–1417. doi: 10.1016/0024-3205(89)90399-8. [DOI] [PubMed] [Google Scholar]
  9. Hedges A., Turner P. Beta-receptors in human isolated smooth muscle. Br J Pharmacol. 1969 Oct;37(2):547P–548P. [PMC free article] [PubMed] [Google Scholar]
  10. Kellow J. E., Phillips S. F., Miller L. J., Zinsmeister A. R. Dysmotility of the small intestine in irritable bowel syndrome. Gut. 1988 Sep;29(9):1236–1243. doi: 10.1136/gut.29.9.1236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lyrenäs E., Abrahamsson H., Dotevall G. Effects of beta-adrenoceptor stimulation on rectosigmoid motility in man. Dig Dis Sci. 1985 Jun;30(6):536–540. doi: 10.1007/BF01320259. [DOI] [PubMed] [Google Scholar]
  12. Lyrenäs E., Abrahamsson H., Dotevall G. Rectosigmoid motility response to beta-adrenoceptor stimulation in patients with the irritable bowel syndrome. Scand J Gastroenterol. 1985 Dec;20(10):1163–1168. doi: 10.3109/00365528509089270. [DOI] [PubMed] [Google Scholar]
  13. Metz G., Gassull M. A., Leeds A. R., Blendis L. M., Jenkins D. J. A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling. Clin Sci Mol Med. 1976 Mar;50(3):237–240. doi: 10.1042/cs0500237. [DOI] [PubMed] [Google Scholar]
  14. Read N. W., Al-Janabi M. N., Bates T. E., Holgate A. M., Cann P. A., Kinsman R. I., McFarlane A., Brown C. Interpretation of the breath hydrogen profile obtained after ingesting a solid meal containing unabsorbable carbohydrate. Gut. 1985 Aug;26(8):834–842. doi: 10.1136/gut.26.8.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rees M. R., Clark R. A., Holdsworth C. D., Barber D. C., Howlett P. J. The effect of beta-adrenoceptor agonists and antagonists on gastric emptying in man. Br J Clin Pharmacol. 1980 Dec;10(6):551–554. doi: 10.1111/j.1365-2125.1980.tb00509.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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