Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1992 Oct;34(4):281–288. doi: 10.1111/j.1365-2125.1992.tb05632.x

Diethylcarbamazine in the treatment of patients with onchocerciasis.

K Awadzi 1, H M Gilles 1
PMCID: PMC1381407  PMID: 1457260

Full text

PDF
285

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS J. C., WOODRUFF A. W. Diethylcarbamazine in the treatment of onchocerciasis. Trans R Soc Trop Med Hyg. 1953 Jan;47(1):66–69. doi: 10.1016/0035-9203(53)90025-x. [DOI] [PubMed] [Google Scholar]
  2. Albiez E. J., Walter G., Kaiser A., Newland H. S., White A. T., Greene B. M., Taylor H. R., Büttner D. W. Effects of high doses of diethylcarbamazine on adult Onchocerca volvulus examined by the collagenase technique and by histology. Trop Med Parasitol. 1988 Jun;39(2):87–92. [PubMed] [Google Scholar]
  3. Anderson J., Fuglsang H. Topical diethylcarbamazine in ocular onchocerciasis. Trans R Soc Trop Med Hyg. 1973;67(5):710–717. doi: 10.1016/0035-9203(73)90042-4. [DOI] [PubMed] [Google Scholar]
  4. Anderson J., Fuglsang H., de C Marshall T. F. Effects of diethylcarbamazine on ocular onchocerciasis. Tropenmed Parasitol. 1976 Sep;27(3):263–278. [PubMed] [Google Scholar]
  5. Aviel E., David R. Topical diethylcarbamazine in ocular onchocerciasis. Isr J Med Sci. 1972 Aug-Sep;8(8):1166–1168. [PubMed] [Google Scholar]
  6. Awadzi K., Adjepon-Yamoah K. K., Edwards G., Orme M. L., Breckenridge A. M., Gilles H. M. The effect of moderate urine alkalinisation on low dose diethylcarbamazine therapy in patients with onchocerciasis. Br J Clin Pharmacol. 1986 Jun;21(6):669–676. doi: 10.1111/j.1365-2125.1986.tb05232.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Awadzi K., Dadzie K. Y., Schulz-Key H., Gilles H. M., Fulford A. J., Aziz M. A. The chemotherapy of onchocerciasis. XI. A double-blind comparative study of ivermectin, diethylcarbamazine and placebo in human onchocerciasis in northern Ghana. Ann Trop Med Parasitol. 1986 Aug;80(4):433–442. doi: 10.1080/00034983.1986.11812044. [DOI] [PubMed] [Google Scholar]
  8. Awadzi K., Orme M. L., Breckenridge A. M., Gilles H. M. The chemotherapy of onchocerciasis IX. The effect of prednisone plus cyproheptadine on the Mazzotti reaction. Ann Trop Med Parasitol. 1982 Oct;76(5):547–555. doi: 10.1080/00034983.1982.11687579. [DOI] [PubMed] [Google Scholar]
  9. Awadzi K., Orme M. L., Breckenridge A. M., Gilles H. M. The chemotherapy of onchocerciasis VI. The effect of indomethacin and cyproheptadine on the Mazzotti reaction. Ann Trop Med Parasitol. 1982 Jun;76(3):323–330. doi: 10.1080/00034983.1982.11687548. [DOI] [PubMed] [Google Scholar]
  10. Awadzi K., Orme M. L., Breckenridge A. M., Gilles H. M. The chemotherapy of onchocerciasis VII. The effect of prednisone on the Mazzotti reaction. Ann Trop Med Parasitol. 1982 Jun;76(3):331–338. doi: 10.1080/00034983.1982.11687549. [DOI] [PubMed] [Google Scholar]
  11. Awadzi K. The chemotherapy of onchocerciasis II. Quantitation of the clinical reaction to microfilaricides. Ann Trop Med Parasitol. 1980 Apr;74(2):189–197. doi: 10.1080/00034983.1980.11687330. [DOI] [PubMed] [Google Scholar]
  12. Ben-Sira I., Aviel E., Lazar M., Liebermann T. W., Leopold I. H. Topical hetrazan in the treatment of ocular onchocerciasis. Am J Ophthalmol. 1970 Nov;70(5):741–743. doi: 10.1016/0002-9394(70)90493-9. [DOI] [PubMed] [Google Scholar]
  13. Berhard J. A., Figueroa L. N., García Manzo G. A. Triamcinolona como profiláctico en las reacciones secundarias producidas por el hetrazán. Salud Publica Mex. 1964 Sep-Oct;6(5):835–841. [PubMed] [Google Scholar]
  14. Bird A. C., el-Sheikh H., Anderson J., Fuglsang H. Changes in visual function and in the posterior segment of the eye during treatment of onchocerciasis with diethylcarbamazine citrate. Br J Ophthalmol. 1980 Mar;64(3):191–200. doi: 10.1136/bjo.64.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Bryceson A. D., Warrell D. A., Pope H. M. Dangerous reactions to treatment of onchocerciasis with diethylcarbamazine. Br Med J. 1977 Mar 19;1(6063):742–744. doi: 10.1136/bmj.1.6063.742. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Campbell W. C. Ivermectin as an antiparasitic agent for use in humans. Annu Rev Microbiol. 1991;45:445–474. doi: 10.1146/annurev.mi.45.100191.002305. [DOI] [PubMed] [Google Scholar]
  17. DUKE B. O. The reappearance, rate of increase and distribution of the microfilariae of Onchocerca volvulus following treatment with diethylcarbamazine. Trans R Soc Trop Med Hyg. 1957 Jan;51(1):37–44. doi: 10.1016/0035-9203(57)90004-4. [DOI] [PubMed] [Google Scholar]
  18. Dadzie K. Y., Bird A. C., Awadzi K., Schulz-Key H., Gilles H. M., Aziz M. A. Ocular findings in a double-blind study of ivermectin versus diethylcarbamazine versus placebo in the treatment of onchocerciasis. Br J Ophthalmol. 1987 Feb;71(2):78–85. doi: 10.1136/bjo.71.2.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Diallo S., Aziz M. A., Lariviere M., Diallo J. S., Diop-Mar I., N'Dir O., Badiane S., Py D., Schulz-Key H., Gaxotte P. A double-blind comparison of the efficacy and safety of ivermectin and diethylcarbamazine in a placebo controlled study of Senegalese patients with onchocerciasis. Trans R Soc Trop Med Hyg. 1986;80(6):927–934. doi: 10.1016/0035-9203(86)90262-2. [DOI] [PubMed] [Google Scholar]
  20. Duke B. O. The effects of drugs on Onchocerca volvulus. 1. Methods of assessment, population dynamics of the parasite and the effects of diethylcarbamazine. Bull World Health Organ. 1968;39(2):137–146. [PMC free article] [PubMed] [Google Scholar]
  21. Edwards G., Awadzi K., Breckenridge A. M., Gilles H. M., Orme M. L., Ward S. A. Diethylcarbamazine disposition in patients with onchocerciasis. Clin Pharmacol Ther. 1981 Oct;30(4):551–557. doi: 10.1038/clpt.1981.202. [DOI] [PubMed] [Google Scholar]
  22. Edwards G., Breckenridge A. M., Adjepon-Yamoah K. K., Orme M. L., Ward S. A. The effect of variations in urinary pH on the pharmacokinetics of diethylcarbamazine. Br J Clin Pharmacol. 1981 Dec;12(6):807–812. doi: 10.1111/j.1365-2125.1981.tb01311.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Edwards G., Breckenridge A. M. Clinical pharmacokinetics of anthelmintic drugs. Clin Pharmacokinet. 1988 Aug;15(2):67–93. doi: 10.2165/00003088-198815020-00001. [DOI] [PubMed] [Google Scholar]
  24. Francis H., Awadzi K., Ottesen E. A. The Mazzotti reaction following treatment of onchocerciasis with diethylcarbamazine: clinical severity as a function of infection intensity. Am J Trop Med Hyg. 1985 May;34(3):529–536. doi: 10.4269/ajtmh.1985.34.529. [DOI] [PubMed] [Google Scholar]
  25. Fuglsang H., Anderson J. Deseril and diethylcarbamazine in the treatment of onchocerciasis. Trans R Soc Trop Med Hyg. 1976;70(5-6):534–534. doi: 10.1016/0035-9203(76)90151-6. [DOI] [PubMed] [Google Scholar]
  26. Fuglsang H., Anderson J. Letter: Collapse during treatment of onchocerciasis with diethylcarbamazine. Trans R Soc Trop Med Hyg. 1974;68(1):72–73. doi: 10.1016/0035-9203(74)90259-4. [DOI] [PubMed] [Google Scholar]
  27. Fulford A. J., Macfarlane S. B., Awadzi K., Bell D. R., Gilles H. M. The chemotherapy of onchocerciasis. XII. The prediction of microfilarial loads in patients with onchocerciasis after treatment with diethylcarbamazine in northern Ghana. Ann Trop Med Parasitol. 1987 Dec;81(6):701–711. [PubMed] [Google Scholar]
  28. Garcia Manzo A., Figueroa L. N., Bernhard J. A. El uso del fosfato de betametasona para controlar las reacciones secundarias producidas por Hetrazán en pacientes oncocercosos. Salud Publica Mex. 1965 Mar-Apr;7(2):209–212. [PubMed] [Google Scholar]
  29. Greene B. M., Taylor H. R., Cupp E. W., Murphy R. P., White A. T., Aziz M. A., Schulz-Key H., D'Anna S. A., Newland H. S., Goldschmidt L. P. Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. N Engl J Med. 1985 Jul 18;313(3):133–138. doi: 10.1056/NEJM198507183130301. [DOI] [PubMed] [Google Scholar]
  30. HAWKING F. A histological study of onchocerciasis treated with hetrazan. Br Med J. 1952 May 10;1(4766):992–994. doi: 10.1136/bmj.1.4766.992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Henson P. M., Mackenzie C. D., Spector W. G. Inflammatory reactions in onchocerciasis: a report on current knowledge and recommendations for further study. Bull World Health Organ. 1979;57(5):667–682. [PMC free article] [PubMed] [Google Scholar]
  32. Hero M., Bird A. C., Awadzi K. Quantification of the ocular reactions to microfilaricides in the chemotherapy of onchocerciasis. Eye (Lond) 1992;6(Pt 1):93–96. doi: 10.1038/eye.1992.19. [DOI] [PubMed] [Google Scholar]
  33. Jones B. R., Anderson J., Fuglsang H. Effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis, and the possibilities of improved therapy from continuous non-pulsed delivery. Br J Ophthalmol. 1978 Jul;62(7):428–439. doi: 10.1136/bjo.62.7.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. LAGRAULET J., MONJUSIAU A., DURAND B. ETUDE CLINIQUE DE L'ACTION DU M'ETHYSERGIDE SUR LE CHOC TH'ERAPEUTIQUE 'A LA DI'ETHYLCARBAMAZINE DANS L'ONCHOCERCOSE (ESSAI PR'ELIMINAIRE) Bull Soc Pathol Exot Filiales. 1964 May-Jul;57:528–536. [PubMed] [Google Scholar]
  35. Langham M. E., Beltranena F. The Onchocerca volvulus micro- and macrofilarial responses in onchocerciasis patients to increased dosage of diethylcarbamazine. Trop Med Parasitol. 1985 Sep;36(3):175–179. [PubMed] [Google Scholar]
  36. Langham M. E., Traub Z. D., Richardson R. A transepidermal chemotherapy of onchocerciasis. Tropenmed Parasitol. 1978 Jun;29(2):156–162. [PubMed] [Google Scholar]
  37. Lariviere M., Vingtain P., Aziz M., Beauvais B., Weimann D., Derouin F., Ginoux J., Schulz-Key H., Gaxotte P., Basset D. Double-blind study of ivermectin and diethylcarbamazine in African onchocerciasis patients with ocular involvement. Lancet. 1985 Jul 27;2(8448):174–177. doi: 10.1016/s0140-6736(85)91496-5. [DOI] [PubMed] [Google Scholar]
  38. MARKELL E. K., TURNER J. Cortisone and prednisone in the suppression of allergic reactions to diethylcarbamazine treatment of onchocerciasis. Am J Trop Med Hyg. 1957 May;6(3):546–552. doi: 10.4269/ajtmh.1957.6.546. [DOI] [PubMed] [Google Scholar]
  39. MARTINEZ BAEZ M. Acción del hetrazán sobre Onchocerca volvulus al estado adulto. Medicina (Mex) 1952 Nov 25;32(664):521–523. [PubMed] [Google Scholar]
  40. MAZZOTTI L. Observations on the use of hetrazan in onchocerciasis in Mexico. Am J Trop Med Hyg. 1951 Sep;31(5):628–632. doi: 10.4269/ajtmh.1951.s1-31.628. [DOI] [PubMed] [Google Scholar]
  41. Philippon G., Moreau J. P., Le Chapois D., Prod'hon J., Flye Sainte-Marie F. Evaluation de protocoles de traitement collectig de l'onchocercose par la diethylcarbamazine. Med Trop (Mars) 1981 Nov-Dec;41(6):613–618. [PubMed] [Google Scholar]
  42. Prod'hon J., Moreau J. P., Mongin C. Chimiothérapie de l'onchocercose. I. Essais de traitement de masse par la diéthylcarbamazine, le lévamisole et l'association diéthylcarbamazine + lévamisole. Med Trop (Mars) 1979 Nov-Dec;39(6):619–628. [PubMed] [Google Scholar]
  43. Rougemont A., Boisson M. E., Borges da Silva G., Zander N. Un essai de traitement collectif par la diéthylcarbamazine dans un village d'hyperendémie onchocerquienne de la région de Bamako (Mali) Bull World Health Organ. 1976;54(4):403–410. [PMC free article] [PubMed] [Google Scholar]
  44. Rée G. H. Onchocerciasis treated with diethylcarbamazine. Br J Dermatol. 1977 Nov;97(5):551–554. doi: 10.1111/j.1365-2133.1977.tb14134.x. [DOI] [PubMed] [Google Scholar]
  45. Sowa J., Sowa S. C. Long-term treatment of onchocerciasis in children with low doses of diethylcarbamazine. Ann Trop Med Parasitol. 1978 Feb;72(1):79–85. doi: 10.1080/00034983.1978.11719282. [DOI] [PubMed] [Google Scholar]
  46. TORROELLA J. RESULTADO DE LA APLICACI'ON EN EL CAMPO DE LA DIETILCARBAMAZINA ASOCIADA AL CLORHIDRATO DE METDILAZINA Y TRIAMCINOLONA; ESTAD'ISTICA DE LAS REACCIONES DESFAVORABLES COMPARATIVAMENTE CON EL EMPLEO DE LA DIETILCARBAMAZINA SOLA. Salud Publica Mex. 1964 Jul-Aug;6:595–597. [PubMed] [Google Scholar]
  47. Taylor H. R., Greene B. M., Langham M. E. Controlled clinical trial of oral and topical diethylcarbamazine in treatment of onchocerciasis. Lancet. 1980 May 3;1(8175):943–946. doi: 10.1016/s0140-6736(80)91402-6. [DOI] [PubMed] [Google Scholar]
  48. Villamayor C. A. Estudio para valorar la prevención del choque terapéutico en la oncocercosis. Salud Publica Mex. 1970 May-Jun;12(3):321–331. [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES