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. 1992 Nov;34(5):415–420. doi: 10.1111/j.1365-2125.1992.tb05650.x

7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.

J Hakkola 1, J Mäenpää 1, R T Mayer 1, S S Park 1, H V Gelboin 1, O Pelkonen 1
PMCID: PMC1381470  PMID: 1467136

Abstract

1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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