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. 1995 Apr;36(4):581–584. doi: 10.1136/gut.36.4.581

Hereditary proctalgia fugax and constipation: report of a second family.

A F Celik 1, P Katsinelos 1, N W Read 1, M I Khan 1, T C Donnelly 1
PMCID: PMC1382501  PMID: 7737568

Abstract

A second family with hereditary proctalgia fugax and internal anal sphincter hypertrophy associated with constipation is described. Anorectal ultrasonography, manometry, and sensory tests were conducted in two symptomatic and one asymptomatic subjects within the same family and further clinical information was obtained from other family members. The inheritance would correspond to an autosomal dominant condition with incomplete penetration, presenting after the second decade of life. Physiological studies showed deep, ultraslow waves and an absence of internal anal sphincter relaxation on rectal distension in the two most severely affected family members, suggesting the possibility of a neuropathic origin. Both of these patients had an abnormally high blood pressure. After treatment with a sustained release formulation of the calcium antagonist, nifedipine, their blood pressure returned to normal, anal tone was reduced, and the frequency and intensity of anal pain was suppressed. These together improved the quality of the patients' sleep, which had previously been very troubled because of night time attacks of anal pain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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