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. 1996 Jul;39(1):43–47. doi: 10.1136/gut.39.1.43

Factors associated with serum antibodies to reticulin, endomysium, and gliadin in an adult population.

S A McMillan 1, R P Watson 1, E E McCrum 1, A E Evans 1
PMCID: PMC1383229  PMID: 8881807

Abstract

BACKGROUND: Gluten sensitivity is thought to be significantly under-diagnosed in the population. AIMS: The aims of this study were to investigate the prevalence of antibodies associated with coeliac disease in a large representative sample of the adult population and to determine factors that are associated with their presence. PATIENTS: Serum samples from 5420 subjects with approximately equal numbers in each five year group from ages 15 to 65 years were obtained from the Belfast MONICA project and Change of Heart surveys, set up to monitor and assess risk factors associated with coronary heart disease in the population. METHODS: Using immunofluorescence and enzyme linked immunosorbent assay (ELISA) techniques autoantibodies, including those to reticulin, endomysium, and gliadin were determined. RESULTS: The results establish that IgA antigliadin antibody prevalence is high at 5.7%. Antiendomysial antibody was present in 1.2% of samples and gliadin and endomysial antibodies in 0.4%. No significant differences were found between men and women, area of residence in Northern Ireland or the year of sampling over the eight year period. However, there was a significant increase in the prevalence of IgA gliadin antibody, and to a lesser extent IgA endomysial antibody, with increasing age. CONCLUSION: The high prevalence of these positive antibodies suggests that coeliac disease may be relatively common in Northern Ireland.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Catassi C., Rätsch I. M., Fabiani E., Rossini M., Bordicchia F., Candela F., Coppa G. V., Giorgi P. L. Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994 Jan 22;343(8891):200–203. doi: 10.1016/s0140-6736(94)90989-x. [DOI] [PubMed] [Google Scholar]
  2. Collin P., Helin H., Mäki M., Hällström O., Karvonen A. L. Follow-up of patients positive in reticulin and gliadin antibody tests with normal small-bowel biopsy findings. Scand J Gastroenterol. 1993 Jul;28(7):595–598. doi: 10.3109/00365529309096094. [DOI] [PubMed] [Google Scholar]
  3. Corrao G., Corazza G. R., Andreani M. L., Torchio P., Valentini R. A., Galatola G., Quaglino D., Gasbarrini G., di Orio F. Serological screening of coeliac disease: choosing the optimal procedure according to various prevalence values. Gut. 1994 Jun;35(6):771–775. doi: 10.1136/gut.35.6.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grodzinsky E., Franzen L., Hed J., Ström M. High prevalence of celiac disease in healthy adults revealed by antigliadin antibodies. Ann Allergy. 1992 Jul;69(1):66–70. [PubMed] [Google Scholar]
  5. Grodzinsky E., Hed J., Liedén G., Sjögren F., Ström M. Presence of IgA and IgG antigliadin antibodies in healthy adults as measured by micro-ELISA. Effect of various cutoff levels on specificity and sensitivity when diagnosing coeliac disease. Int Arch Allergy Appl Immunol. 1990;92(2):119–123. doi: 10.1159/000235201. [DOI] [PubMed] [Google Scholar]
  6. Hallert C., Gotthard R., Norrby K., Walan A. On the prevalence of adult coeliac disease in Sweden. Scand J Gastroenterol. 1981;16(2):257–261. doi: 10.3109/00365528109181965. [DOI] [PubMed] [Google Scholar]
  7. Holmes G. K., Prior P., Lane M. R., Pope D., Allan R. N. Malignancy in coeliac disease--effect of a gluten free diet. Gut. 1989 Mar;30(3):333–338. doi: 10.1136/gut.30.3.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lerner A., Kumar V., Iancu T. C. Immunological diagnosis of childhood coeliac disease: comparison between antigliadin, antireticulin and antiendomysial antibodies. Clin Exp Immunol. 1994 Jan;95(1):78–82. doi: 10.1111/j.1365-2249.1994.tb06018.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Logan R. F., Tucker G., Rifkind E. A., Heading R. C., Ferguson A. Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-79. Br Med J (Clin Res Ed) 1983 Jan 8;286(6359):95–97. doi: 10.1136/bmj.286.6359.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MACDONALD W. C., DOBBINS W. O., 3rd, RUBIN C. E. STUDIES OF THE FAMILIAL NATURE OF CELIAC SPRUE USING BIOPSY OF THE SMALL INTESTINE. N Engl J Med. 1965 Mar 4;272:448–456. doi: 10.1056/NEJM196503042720903. [DOI] [PubMed] [Google Scholar]
  11. Mazure R., Vazquez H., Gonzalez D., Mautalen C., Pedreira S., Boerr L., Bai J. C. Bone mineral affection in asymptomatic adult patients with celiac disease. Am J Gastroenterol. 1994 Dec;89(12):2130–2134. [PubMed] [Google Scholar]
  12. McFarlane X. A., Bhalla A. K., Reeves D. E., Morgan L. M., Robertson D. A. Osteoporosis in treated adult coeliac disease. Gut. 1995 May;36(5):710–714. doi: 10.1136/gut.36.5.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McMillan S. A., Haughton D. J., Biggart J. D., Edgar J. D., Porter K. G., McNeill T. A. Predictive value for coeliac disease of antibodies to gliadin, endomysium, and jejunum in patients attending for jejunal biopsy. BMJ. 1991 Nov 9;303(6811):1163–1165. doi: 10.1136/bmj.303.6811.1163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Midhagen G., Järnerot G., Kraaz W. Adult coeliac disease within a defined geographic area in Sweden. A study of prevalence and associated diseases. Scand J Gastroenterol. 1988 Oct;23(8):1000–1004. doi: 10.3109/00365528809090160. [DOI] [PubMed] [Google Scholar]
  15. O'Farrelly C., Graeme-Cook F., Hourihane D. O., Feighery C., Weir D. G. Histological changes associated with wheat protein antibodies in the absence of villous atrophy. J Clin Pathol. 1987 Oct;40(10):1228–1230. doi: 10.1136/jcp.40.10.1228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Stokes P. L., Ferguson R., Holmes G. K., Cooke W. T. Familial aspects of coeliac disease. Q J Med. 1976 Oct;45(180):567–582. [PubMed] [Google Scholar]
  17. Stokes P. L., Prior P., Sorahan T. M., McWalter R. J., Waterhouse J. A., Cooke W. T. Malignancy in relatives of patients with coeliac disease. Br J Prev Soc Med. 1976 Mar;30(1):17–21. doi: 10.1136/jech.30.1.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Swinson C. M., Levi A. J. Is coeliac disease underdiagnosed? Br Med J. 1980 Nov 8;281(6250):1258–1260. doi: 10.1136/bmj.281.6250.1258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Watson R. G., McMillan S. A., Dickey W., Biggart J. D., Porter K. G. Detection of undiagnosed coeliac disease with atypical features using antireticulin and antigliadin antibodies. Q J Med. 1992 Sep;84(305):713–718. [PubMed] [Google Scholar]

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