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. 1991 Dec;74(4):652–656.

Echinococcus multilocularis antigens modify accessory cell function of macrophages.

N K Rakha 1, J B Dixon 1, S D Carter 1, P S Craig 1, P Jenkins 1, S Folkard 1
PMCID: PMC1384774  PMID: 1783424

Abstract

Peritoneal macrophages and splenic lymphocytes were collected from BALB/c mice, normal or previously infected with Echinococcus multilocularis. In an accessory cell function assay, peritoneal macrophages, in increasing numbers, were added to cultures of splenic lymphocytes. Cultures were stimulated by concanavalin A (Con A) or E. multilocularis culture supernatant (EMSN). Post-infection macrophages, unlike normal macrophages, suppressed Con A- and EMSN-driven lymphocyte transformation. Modification of accessory cells could also be repeatedly induced in vivo by EMSN or a single FPLC fraction of EMSN. Lymphocytes were made more sensitive to accessory cell signals following incubation with EMSN.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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