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. 1990 Dec;71(4):480–485.

Somatostatin receptors on human lymphocytes and leukaemia cells.

K Hiruma 1, T Koike 1, H Nakamura 1, T Sumida 1, T Maeda 1, H Tomioka 1, S Yoshida 1, T Fujita 1
PMCID: PMC1384866  PMID: 2177723

Abstract

Receptors for somatostatin were identified on mitogen-activated human peripheral blood lymphocytes (PBL) and human leukaemic cells in 87.5% of lymphoblastic leukaemia and in 12.5% of non-lymphocytic leukaemia, using a somatostatin radiobinding assay. The specific binding of 125I-somatostatin of these cells increased linearly with the cell numbers and was suppressed by non-iodinated somatostatin. We investigated the distribution of fluorescent somatostatin to mitogen-activated PBL by using a fluorescence-activated cell sorter (FACS). Over 95% of the cell populations bound fluorescent somatostatin and no distinct predilection was found among certain lymphocyte subpopulations and somatostatin receptor-positive cells. Scatchard analysis showed a single class (low affinity) of binding site on mitogen-activated PBL and two classes (high and low affinity) of specific binding sites on lymphoblastic leukaemia cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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