Abstract
Azathioprine metabolism, to red cell 6-thioguanine nucleotides (6TGN), was studied in four patients with pemphigus vulgaris. Throughout treatment blood samples were taken for red cell 6TGN assay and differential white cell counts. Metabolite steady-state occurred in three patients in 2, 2 and 4 months respectively. In the fourth patient red cell 6TGN concentrations increased slowly over 3 years. There was a significant negative correlation between 6TGN concentrations and the white blood cell count (rs = -0.92, P less than 0.0005) in this patient.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Al-Safi S. A., Maddocks J. L. Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms. Br J Clin Pharmacol. 1984 Apr;17(4):417–422. doi: 10.1111/j.1365-2125.1984.tb02366.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Al-Safi S. A., Maddocks J. L. Effects of azathioprine on the human mixed lymphocyte reaction (MLR). Br J Clin Pharmacol. 1983 Feb;15(2):203–209. doi: 10.1111/j.1365-2125.1983.tb01487.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bach J. F., Dardenne M. Serum immunosuppressive activity of azathioprine in normal subjects and patients with liver diseases. Proc R Soc Med. 1972 Mar;65(3):260–263. [PMC free article] [PubMed] [Google Scholar]
- Kinlen L. J., Sheil A. G., Peto J., Doll R. Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs. Br Med J. 1979 Dec 8;2(6203):1461–1466. doi: 10.1136/bmj.2.6203.1461. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lennard L., Brown C. B., Fox M., Maddocks J. L. Azathioprine metabolism in kidney transplant recipients. Br J Clin Pharmacol. 1984 Nov;18(5):693–700. doi: 10.1111/j.1365-2125.1984.tb02531.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lennard L., Maddocks J. L. Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells. J Pharm Pharmacol. 1983 Jan;35(1):15–18. doi: 10.1111/j.2042-7158.1983.tb04255.x. [DOI] [PubMed] [Google Scholar]
- Lennard L., Murphy M. F., Maddocks J. L. Severe megaloblastic anaemia associated with abnormal azathioprine metabolism. Br J Clin Pharmacol. 1984 Feb;17(2):171–172. doi: 10.1111/j.1365-2125.1984.tb02333.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lennard L., Thomas S., Harrington C. I., Maddocks J. L. Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells. Br J Dermatol. 1985 Dec;113(6):723–729. doi: 10.1111/j.1365-2133.1985.tb02408.x. [DOI] [PubMed] [Google Scholar]
- Lever W. F., Schaumburg-Lever G. Immunosuppressants and prednisone in pemphigus vulgaris: therapeutic results obtained in 63 patients between 1961 and 1975. Arch Dermatol. 1977 Sep;113(9):1236–1241. [PubMed] [Google Scholar]
- Lever W. F., Schaumburg-Lever G. Treatment of pemphigus vulgaris. Results obtained in 84 patients between 1961 and 1982. Arch Dermatol. 1984 Jan;120(1):44–47. doi: 10.1001/archderm.120.1.44. [DOI] [PubMed] [Google Scholar]
- Pemphigus: current concepts. Ann Intern Med. 1980 Mar;92(3):396–405. doi: 10.7326/0003-4819-92-3-396. [DOI] [PubMed] [Google Scholar]
- Penn I. Development of cancer in transplantation patients. Adv Surg. 1978;12:155–191. [PubMed] [Google Scholar]
- Szawlowski P. W., Al-Safi S. A., Dooley T., Maddocks J. L. Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome. Br J Clin Pharmacol. 1985 Nov;20(5):489–491. doi: 10.1111/j.1365-2125.1985.tb05104.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tidd D. M., Paterson A. R. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res. 1974 Apr;34(4):738–746. [PubMed] [Google Scholar]