Abstract
Nine patients were given intrathecal injections of midazolam (dose 0.3-2 mg dissolved in 3 ml 5% dextrose). No changes in motor power or general sensation were produced. Resting heart rate and blood pressure were unchanged and normal valsalva manoeuvres were elicited 30 min post-injection. Cardiovascular responses were provoked at a light plane of anaesthesia by intubation of the trachea and manipulation of peritoneum and bowel but not by surgical incision of the skin. Intrathecal administration of midazolam relieved post-operative pain of somatic origin but not of visceral origin. It is concluded that intrathecal midazolam in the dosage used interrupts somatic nociceptive afferent pathways but not abdominal visceral nociceptive afferent pathways.
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Selected References
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- Boralessa H., Senior D. F., Whitwam J. G. Cardiovascular response to intubation. A comparative study of thiopentone and midazolam. Anaesthesia. 1983 Jul;38(7):623–627. doi: 10.1111/j.1365-2044.1983.tb12152.x. [DOI] [PubMed] [Google Scholar]
- Braestrup C., Nielsen M. GABA reduces binding of 3H-methyl beta-carboline-3-carboxylate to brain benzodiazepine receptors. Nature. 1981 Dec 3;294(5840):472–474. doi: 10.1038/294472a0. [DOI] [PubMed] [Google Scholar]
- Cervero F. Visceral nociception: peripheral and central aspects of visceral nociceptive systems. Philos Trans R Soc Lond B Biol Sci. 1985 Feb 19;308(1136):325–337. doi: 10.1098/rstb.1985.0033. [DOI] [PubMed] [Google Scholar]
- Deckert J., Kuhn W., Przuntek H. Endogenous benzodiazepine ligands in human cerebrospinal fluid. Peptides. 1984 May-Jun;5(3):641–644. doi: 10.1016/0196-9781(84)90096-2. [DOI] [PubMed] [Google Scholar]
- Möhler H., Okada T. Benzodiazepine receptor: demonstration in the central nervous system. Science. 1977 Nov 25;198(4319):849–851. doi: 10.1126/science.918669. [DOI] [PubMed] [Google Scholar]
- Niv D., Whitwam J. G., Loh L. Depression of nociceptive sympathetic reflexes by the intrathecal administration of midazolam. Br J Anaesth. 1983 Jun;55(6):541–547. doi: 10.1093/bja/55.6.541. [DOI] [PubMed] [Google Scholar]
- Schoch P., Richards J. G., Häring P., Takacs B., Stähli C., Staehelin T., Haefely W., Möhler H. Co-localization of GABA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies. Nature. 1985 Mar 14;314(6007):168–171. doi: 10.1038/314168a0. [DOI] [PubMed] [Google Scholar]
- Whitwam J. G. Benzodiazepine receptors. Anaesthesia. 1983 Feb;38(2):93–95. doi: 10.1111/j.1365-2044.1983.tb13923.x. [DOI] [PubMed] [Google Scholar]
- Whitwam J. G., Niv D., Loh L., Jack R. D. Depression of nociceptive reflexes by intrathecal benzodiazepine in dogs. Lancet. 1982 Dec 25;2(8313):1465–1465. doi: 10.1016/s0140-6736(82)91368-x. [DOI] [PubMed] [Google Scholar]