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. 1987 Sep;24(3):329–334. doi: 10.1111/j.1365-2125.1987.tb03177.x

Cyclosporin-phenytoin interaction: re-evaluation using metabolite data.

M Rowland 1, S K Gupta 1
PMCID: PMC1386254  PMID: 3663449

Abstract

1 Freeman et al. (1984) evoked enzyme induction to explain the lower plasma concentration of cyclosporin following phenytoin co-administration in man. 2 We have examined the whole blood concentration data of two metabolites of cyclosporin, as well as unchanged drug, all measured by h.p.l.c., associated with the above mentioned study. 3 Phenytoin produced no significant effect on either the terminal half-life of both metabolites or the ratio of area under the concentration-time curve of metabolite to parent drug. 4 These data strongly suggest that phenytoin reduces the absorption of cyclosporin; they do not generally support the idea that phenytoin induces cyclosporin metabolism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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