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. 1988 Mar;25(3):397–400. doi: 10.1111/j.1365-2125.1988.tb03319.x

Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.

R A Robson 1, J O Miners 1, D J Birkett 1
PMCID: PMC1386365  PMID: 3358901

Abstract

Nine healthy male volunteers were studied to assess the possibility of an interaction between theophylline and nifedipine or verapamil using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly with and without nifedipine 20 mg 12 hourly and verapamil 80 mg 8 hourly. Nifedipine treatment reduced mean total theophylline clearance by 9%, due to decreased clearances via 1- and 3-demethylation. Verapamil treatment reduced mean total theophylline clearance by 14%, due to decreased clearances via 1- and 3-demethylation and 8-hydroxylation. Verapamil and nifedipine at usual clinical doses are unlikely to cause clinically significant changes in theophylline disposition.

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Selected References

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