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. 1987 Dec;24(6):699–704. doi: 10.1111/j.1365-2125.1987.tb03234.x

The effect of angiotensin II on endogenous noradrenaline release in man.

P H Seidelin 1, W J Coutie 1, A D Struthers 1
PMCID: PMC1386392  PMID: 3440094

Abstract

1. Considerable data from animal studies suggest that angiotensin II exerts a facilitatory effect on noradrenaline release. We sought evidence for such an effect in man by examining how a subpressor dose of angiotensin II (1.5 ng kg-1 min-1) influences the haemodynamic and plasma noradrenaline responses to physiological stimulation of the sympathetic nervous system. 2. The physiological stimuli investigated were a cold pressor test, the response to standing from lying, bicycle exercise and forearm isometric exercise. 3. The presence of the angiotensin II infusion had no effect on the systolic blood pressure, diastolic blood pressure, heart rate or plasma noradrenaline responses to stimulation of the sympathetic nervous system. 4. We have therefore found no evidence to support the enhancement of noradrenaline release by this low dose of angiotensin II in man.

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Selected References

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  1. Ajayi A. A., Campbell B. C., Howie C. A., Reid J. L. Acute and chronic effects of the converting enzyme inhibitors enalapril and lisinopril on reflex control of heart rate in normotensive man. J Hypertens. 1985 Feb;3(1):47–53. doi: 10.1097/00004872-198502000-00008. [DOI] [PubMed] [Google Scholar]
  2. Becker R. H., Struthers A. D., Brown M. J. Effect of captopril on changes in plasma noradrenaline induced by sodium nitroprusside. Br J Clin Pharmacol. 1986 Oct;22(4):409–413. doi: 10.1111/j.1365-2125.1986.tb02910.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown M. J., Jenner D. A. Novel double-isotope technique for enzymatic assay of catecholamines, permitting high precision, sensitivity and plasma sample capacity. Clin Sci (Lond) 1981 Nov;61(5):591–598. doi: 10.1042/cs0610591. [DOI] [PubMed] [Google Scholar]
  4. Brown M. J., Lhoste F. J., Zamboulis C., Ind P. W., Jenner D. A., Dollery C. T. Estimation of sympathetic activity in essential hypertension. Clin Pharmacol Ther. 1982 Jan;31(1):16–22. doi: 10.1038/clpt.1982.3. [DOI] [PubMed] [Google Scholar]
  5. Campbell B. C., Sturani A., Reid J. L. Evidence of parasympathetic activity of the angiotensin converting enzyme inhibitor, captopril, in normotensive man. Clin Sci (Lond) 1985 Jan;68(1):49–56. doi: 10.1042/cs0680049. [DOI] [PubMed] [Google Scholar]
  6. Flammer J., Weidmann P., Glück Z., Ziegler W. H., Reubi F. C. Cardiovascular and endocrine profile of adrenergic neurone blockade in normal and hypertensive man. Am J Med. 1979 Jan;66(1):34–42. doi: 10.1016/0002-9343(79)90479-0. [DOI] [PubMed] [Google Scholar]
  7. Goldstein D. S., McCarty R., Polinsky R. J., Kopin I. J. Relationship between plasma norepinephrine and sympathetic neural activity. Hypertension. 1983 Jul-Aug;5(4):552–559. doi: 10.1161/01.hyp.5.4.552. [DOI] [PubMed] [Google Scholar]
  8. Hatton R., Clough D. P. Captopril interferes with neurogenic vasoconstriction in the pithed rat by angiotensin-dependent mechanisms. J Cardiovasc Pharmacol. 1982 Jan-Feb;4(1):116–123. doi: 10.1097/00005344-198201000-00019. [DOI] [PubMed] [Google Scholar]
  9. Lake C. R., Ziegler M. G., Kopin I. J. Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man. Life Sci. 1976 Jun 1;18(11):1315–1325. doi: 10.1016/0024-3205(76)90210-1. [DOI] [PubMed] [Google Scholar]
  10. MacGregor G. A., Markandu N. D., Roulston J. E., Jones J. C., Morton J. J. Maintenance of blood pressure by the renin-angiotensin system in normal man. Nature. 1981 May 28;291(5813):329–331. doi: 10.1038/291329a0. [DOI] [PubMed] [Google Scholar]
  11. Mendelsohn F. A., Doyle A. E., Gray G. W. Lack of response of sympathetic nervous system to angiotensin infusion. Lancet. 1980 Mar 1;1(8166):492–493. doi: 10.1016/s0140-6736(80)91045-4. [DOI] [PubMed] [Google Scholar]
  12. Millar J. A., Derkx F. H., McLean K., Reid J. L. Pharmacodynamics of converting enzyme inhibition: the cardiovascular, endocrine and autonomic effects of MK421 (enalapril) and MK521. Br J Clin Pharmacol. 1982 Sep;14(3):347–355. doi: 10.1111/j.1365-2125.1982.tb01990.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morton J. J., Webb D. J. Measurement of plasma angiotensin II. Clin Sci (Lond) 1985 Apr;68(4):483–484. doi: 10.1042/cs0680483. [DOI] [PubMed] [Google Scholar]
  14. Niarchos A. P., Pickering T. G., Morganti A., Laragh J. H. Plasma catecholamines and cardiovascular responses during converting enzyme inhibition in normotensive and hypertensive man. Clin Exp Hypertens A. 1982;4(4-5):761–789. doi: 10.3109/10641968209061612. [DOI] [PubMed] [Google Scholar]
  15. Nicholls M. G., Espiner E. A., Miles K. D., Zweifler A. J., Julius S. Evidence against an interaction of angiotensin II with the sympathetic nervous system in man. Clin Endocrinol (Oxf) 1981 Nov;15(5):423–430. doi: 10.1111/j.1365-2265.1981.tb00684.x. [DOI] [PubMed] [Google Scholar]
  16. Nielsen S. L., Christensen N. J., Olsen N., Lassen N. A. Raynaud's phenomenon: peripheral catecholamine concentration and effect of sympathectomy. Acta Chir Scand Suppl. 1980;502:57–62. [PubMed] [Google Scholar]
  17. Oelkers W., Brown J. J., Fraser R., Lever A. F., Morton J. J., Robertson J. I. Sensitization of the adrenal cortex to angiotensin II in sodium-deplete man. Circ Res. 1974 Jan;34(1):69–77. doi: 10.1161/01.res.40.4.69. [DOI] [PubMed] [Google Scholar]
  18. Robertson D., Johnson G. A., Robertson R. M., Nies A. S., Shand D. G., Oates J. A. Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man. Circulation. 1979 Apr;59(4):637–643. doi: 10.1161/01.cir.59.4.637. [DOI] [PubMed] [Google Scholar]
  19. Struthers A. D., Burrin J. M., Brown M. J. Exercise-induced increases in plasma catecholamines and growth hormone are augmented by selective alpha 2-adrenoceptor blockade in man. Neuroendocrinology. 1986;44(1):22–28. doi: 10.1159/000124616. [DOI] [PubMed] [Google Scholar]
  20. Tree M., Morton J. J. Evidence that the acute hypotensive effect of captopril in dogs is not wholly explained by a reduction of plasma angiotensin II and its direct vasoconstrictor effect. Clin Sci (Lond) 1980 Dec;59(6):451–456. doi: 10.1042/cs0590451. [DOI] [PubMed] [Google Scholar]
  21. Wallin B. G., Mörlin C., Hjemdahl P. Muscle sympathetic activity and venous plasma noradrenaline concentrations during static exercise in normotensive and hypertensive subjects. Acta Physiol Scand. 1987 Apr;129(4):489–497. doi: 10.1111/j.1748-1716.1987.tb08088.x. [DOI] [PubMed] [Google Scholar]
  22. Wallin B. G., Sundlöf G., Eriksson B. M., Dominiak P., Grobecker H., Lindblad L. E. Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiol Scand. 1981 Jan;111(1):69–73. doi: 10.1111/j.1748-1716.1981.tb06706.x. [DOI] [PubMed] [Google Scholar]
  23. Watson R. D., Hamilton C. A., Jones D. H., Reid J. L., Stallard T. J., Littler W. A. Sequential changes in plasma noradrenaline during bicycle exercise. Clin Sci (Lond) 1980 Jan;58(1):37–43. doi: 10.1042/cs0580037. [DOI] [PubMed] [Google Scholar]
  24. Zimmerman B. G., Sybertz E. J., Wong P. C. Interaction between sympathetic and renin-angiotensin system. J Hypertens. 1984 Dec;2(6):581–587. doi: 10.1097/00004872-198412000-00002. [DOI] [PubMed] [Google Scholar]
  25. Zimmerman B. G., Whitmore L. Effect of angiotensin and phenoxybenzamine on release of norepinephrine in vessels during sympathetic nerve stimulation. Int J Neuropharmacol. 1967 Jan;6(1):27–38. doi: 10.1016/0028-3908(67)90039-1. [DOI] [PubMed] [Google Scholar]

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