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. 1987 Dec;24(6):747–752. doi: 10.1111/j.1365-2125.1987.tb03241.x

Effects of silybin on histamine release from human basophil leucocytes.

A Miadonna 1, A Tedeschi 1, E Leggieri 1, M Lorini 1, M Froldi 1, C Zanussi 1
PMCID: PMC1386399  PMID: 2449903

Abstract

1. Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. 2. The f-met peptide and anti-IgE-induced histamine release was significantly (P less than 0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P greater than 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P less than 0.05) reversed by elevating extracellular calcium concentrations. 3. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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