Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1988 Aug;26(2):179–182. doi: 10.1111/j.1365-2125.1988.tb03384.x

Passage of chloroquine into semen.

E I Ette 1, J I Ogonor 1, E E Essien 1
PMCID: PMC1386525  PMID: 3207554

Abstract

The passage of chloroquine into semen was investigated in four healthy men following the oral administration of four chloroquine sulphate tablets (600 mg base) to each subject. Chloroquine was found to be excreted into semen with a slow transfer rate constant of 0.0002 min-1, and the semen/plasma ratio based on regression analysis was 0.40 +/- 0.06 (mean +/- s.d.). It is concluded that the passage of chloroquine from plasma to semen occurs by passive diffusion.

Full text

PDF
179

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alving A. S., Eichelberger L., Craige B., Jones R., Whorton C. M., Pullman T. N. STUDIES ON THE CHRONIC TOXICITY OF CHLOROQUINE (SN-7618). J Clin Invest. 1948 May;27(3 Pt 2):60–65. doi: 10.1172/JCI101974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Collier J. G., Flower R. J. Effect of aspirin on human seminal prostaglandins. Lancet. 1971 Oct 16;2(7729):852–853. doi: 10.1016/s0140-6736(71)90225-x. [DOI] [PubMed] [Google Scholar]
  3. Didolkar A. K., Patel P. B., Roychowdhury D. Effect of aspirin on spermatogenesis in mature and immature rats. Int J Androl. 1980 Oct;3(5):585–593. doi: 10.1111/j.1365-2605.1980.tb00146.x. [DOI] [PubMed] [Google Scholar]
  4. Frisk-Holmberg M., Bergkvist Y., Domeij-Nyberg B., Hellström L., Jansson F. Chloroquine serum concentration and side effects: evidence for dose-dependent kinetics. Clin Pharmacol Ther. 1979 Mar;25(3):345–350. doi: 10.1002/cpt1979253345. [DOI] [PubMed] [Google Scholar]
  5. Gustafsson L. L., Walker O., Alván G., Beermann B., Estevez F., Gleisner L., Lindström B., Sjöqvist F. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol. 1983 Apr;15(4):471–479. doi: 10.1111/j.1365-2125.1983.tb01532.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HART C. W., NAUNTON R. F. THE OTOTOXICITY OF CHLOROQUINE PHOSPHATE. Arch Otolaryngol. 1964 Oct;80:407–412. doi: 10.1001/archotol.1964.00750040419009. [DOI] [PubMed] [Google Scholar]
  7. HOGBEN C. A., SCHANKER L. S., TOCCO D. J., BRODIE B. B. Absorption of drugs from the stomach. II. The human. J Pharmacol Exp Ther. 1957 Aug;120(4):540–545. [PubMed] [Google Scholar]
  8. Hall A. P. The treatment of malaria. Br Med J. 1976 Feb 7;1(6005):323–328. doi: 10.1136/bmj.1.6005.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jacobson M. F., Goldman A. S., Syme R. H. Coffee and birth defects. Lancet. 1981 Jun 27;1(8235):1415–1416. doi: 10.1016/s0140-6736(81)92586-1. [DOI] [PubMed] [Google Scholar]
  10. Jubiz W., Frailey J. Seminal fluid and plasma prostaglandin responses to aspirin in normal subjects. Fertil Steril. 1973 Dec;24(12):977–978. doi: 10.1016/s0015-0282(16)40098-1. [DOI] [PubMed] [Google Scholar]
  11. Kakemi K., Arita T., Hori R., Konishi R., Nishimura K. Absorption and exretion of drugs. XXXIV. An aspect of the mechanism of drug absorption from the intestinal tract in rats. Chem Pharm Bull (Tokyo) 1969 Feb;17(2):255–261. doi: 10.1248/cpb.17.255. [DOI] [PubMed] [Google Scholar]
  12. LUTWAK-MANN C. OBSERVATIONS ON PROGENY OF THALIDOMIDE-TREATED MALE RABBITS. Br Med J. 1964 Apr 25;1(5390):1090–1091. doi: 10.1136/bmj.1.5390.1090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lewis R., Lauersen N. H., Birnbaum S. Malaria associated with pregnancy. Obstet Gynecol. 1973 Nov;42(5):696–700. [PubMed] [Google Scholar]
  14. Matsuzawa Y., Hostetler K. Y. Effects of chloroquine and 4,4'-bis(diethylaminoethoxy)alpha, beta-diethyldiphenylethane on the incorporation of [3H]glycerol into the phospholipids of rat liver lysosomes and other subcellular fractions, in vivo. Biochim Biophys Acta. 1980 Dec 5;620(3):592–602. doi: 10.1016/0005-2760(80)90151-4. [DOI] [PubMed] [Google Scholar]
  15. Matsuzawa Y., Hostetler K. Y. Properties of phospholipase C isolated from rat liver lysosomes. J Biol Chem. 1980 Jan 25;255(2):646–652. [PubMed] [Google Scholar]
  16. Paladine W. J., Cunningham T. J., Donavan M. A., Dumper C. W. Letter: Possible sensitivity to vinblastine in prostatic or seminal fluid. N Engl J Med. 1975 Jan 2;292(1):52–52. doi: 10.1056/nejm197501022920127. [DOI] [PubMed] [Google Scholar]
  17. RALL D. P., STABENAU J. R., ZUBROD C. G. Distribution of drugs between blood and cerebrospinal fluid: general methodology and effect of pH gradients. J Pharmacol Exp Ther. 1959 Mar;125(3):185–193. [PubMed] [Google Scholar]
  18. SCHANKER L. S., TOCCO D. J., BRODIE B. B., HOGBEN C. A. Absorption of drugs from the rat small intestine. J Pharmacol Exp Ther. 1958 May;123(1):81–88. [PubMed] [Google Scholar]
  19. Scott J. E., Persaud T. V. A quantitative study of the effects of acetylsalicylic acid on spermatogenesis and organs of the rat. Int J Fertil. 1978;23(4):282–287. [PubMed] [Google Scholar]
  20. Walker O., Dawodu A. H., Adeyokunnu A. A., Salako L. A., Alvan G. Plasma chloroquine and desethylchloroquine concentrations in children during and after chloroquine treatment for malaria. Br J Clin Pharmacol. 1983 Dec;16(6):701–705. doi: 10.1111/j.1365-2125.1983.tb02244.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES