Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1988 Sep;26(3):245–251. doi: 10.1111/j.1365-2125.1988.tb05273.x

Vascular responses to local atrial natriuretic peptide infusion in man.

D J Webb 1, N Benjamin 1, M J Allen 1, J Brown 1, M O'Flynn 1, J R Cockcroft 1
PMCID: PMC1386535  PMID: 2972307

Abstract

1. The effect on skin and muscle blood flow of arterial infusion of atrial natriuretic peptide (ANP) directly into the forearm circulation, and on venous tone of direct infusion into a dorsal hand vein, was studied in normal subjects. 2. ANP produced a dose-dependent increase in both skin and muscle blood flow, but at equivalent doses, produced no dilatation of noradrenaline-preconstricted dorsal hand veins. These findings indicate that ANP acting locally, is an arterioselective dilator in the upper limb circulation in normal man. 3. Measurements of ANP in venous plasma during arterial infusion suggest marked clearance of ANP across the forearm vascular bed. Such peripheral clearance may, at least in part, account for the short plasma half-life of this peptide. 4. The lowest dose of ANP infused was calculated to produce plasma levels similar to those found in patients with heart failure. The findings with this dose suggest that, in heart failure, circulating levels of ANP may be within a range capable of influencing peripheral vascular resistance directly.

Full text

PDF
251

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahn H., Johansson K., Lundgren O., Nilsson G. E. In vivo evaluation of signal processors for laser Doppler tissue flowmeters. Med Biol Eng Comput. 1987 Mar;25(2):207–211. doi: 10.1007/BF02442852. [DOI] [PubMed] [Google Scholar]
  2. Allen D. E., Gellai M. Cardioinhibitory effect of atrial peptide in conscious rats. Am J Physiol. 1987 Mar;252(3 Pt 2):R610–R616. doi: 10.1152/ajpregu.1987.252.3.R610. [DOI] [PubMed] [Google Scholar]
  3. Almeida F. A., Suzuki M., Maack T. Atrial natriuretic factor increases hematocrit and decreases plasma volume in nephrectomized rats. Life Sci. 1986 Sep 29;39(13):1193–1199. doi: 10.1016/0024-3205(86)90351-6. [DOI] [PubMed] [Google Scholar]
  4. Anderson J. V., Donckier J., Payne N. N., Beacham J., Slater J. D., Bloom S. R. Atrial natriuretic peptide: evidence of action as a natriuretic hormone at physiological plasma concentrations in man. Clin Sci (Lond) 1987 Mar;72(3):305–312. doi: 10.1042/cs0720305. [DOI] [PubMed] [Google Scholar]
  5. Anderson J. V., Struthers A. D., Payne N. N., Slater J. D., Bloom S. R. Atrial natriuretic peptide inhibits the aldosterone response to angiotensin II in man. Clin Sci (Lond) 1986 May;70(5):507–512. doi: 10.1042/cs0700507. [DOI] [PubMed] [Google Scholar]
  6. Ballerman B. J., Brenner B. M. Biologically active atrial peptides. J Clin Invest. 1985 Dec;76(6):2041–2048. doi: 10.1172/JCI112206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bolli P., Müller F. B., Linder L., Raine A. E., Resink T. J., Erne P., Kiowski W., Ritz R., Bühler F. R. The vasodilator potency of atrial natriuretic peptide in man. Circulation. 1987 Jan;75(1):221–228. doi: 10.1161/01.cir.75.1.221. [DOI] [PubMed] [Google Scholar]
  8. Breuhaus B. A., Saneii H. H., Brandt M. A., Chimoskey J. E. Atriopeptin II lowers cardiac output in conscious sheep. Am J Physiol. 1985 Dec;249(6 Pt 2):R776–R780. doi: 10.1152/ajpregu.1985.249.6.R776. [DOI] [PubMed] [Google Scholar]
  9. Brown J., Corr L. Renal mechanisms of human alpha-atrial natriuretic peptide in man. J Physiol. 1987 Jun;387:31–46. doi: 10.1113/jphysiol.1987.sp016560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bussien J. P., Biollaz J., Waeber B., Nussberger J., Turini G. A., Brunner H. R., Brunner-Ferber F., Gomez H. J., Otterbein E. S. Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers. J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):216–220. doi: 10.1097/00005344-198601000-00031. [DOI] [PubMed] [Google Scholar]
  11. Cantin M., Genest J. The heart and the atrial natriuretic factor. Endocr Rev. 1985 Spring;6(2):107–127. doi: 10.1210/edrv-6-2-107. [DOI] [PubMed] [Google Scholar]
  12. Clough D. P., Collis M. G., Conway J., Hatton R., Keddie J. R. Interaction of angiotensin-converting enzyme inhibitors with the function of the sympathetic nervous system. Am J Cardiol. 1982 Apr 21;49(6):1410–1414. doi: 10.1016/0002-9149(82)90352-6. [DOI] [PubMed] [Google Scholar]
  13. Collier J. G., Robinson B. F. Comparison of effects of locally infused angiotensin I and II on hand veins and forearm arteries in man: evidence for converting enzyme activity in limb vessels. Clin Sci Mol Med. 1974 Aug;47(2):189–192. doi: 10.1042/cs0470189. [DOI] [PubMed] [Google Scholar]
  14. Currie M. G., Geller D. M., Cole B. R., Boylan J. G., YuSheng W., Holmberg S. W., Needleman P. Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria. Science. 1983 Jul 1;221(4605):71–73. doi: 10.1126/science.6857267. [DOI] [PubMed] [Google Scholar]
  15. Garcia R., Thibault G., Cantin M., Genest J. Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds. Am J Physiol. 1984 Jul;247(1 Pt 2):R34–R39. doi: 10.1152/ajpregu.1984.247.1.R34. [DOI] [PubMed] [Google Scholar]
  16. Garcia R., Thibault G., Nutt R. F., Cantin M., Genest J. Comparative vasoactive effects of native and synthetic atrial natriuretic factor (ANF). Biochem Biophys Res Commun. 1984 Mar 15;119(2):685–688. doi: 10.1016/s0006-291x(84)80304-6. [DOI] [PubMed] [Google Scholar]
  17. Grammer R. T., Fukumi H., Inagami T., Misono K. S. Rat atrial natriuretic factor. Purification and vasorelaxant activity. Biochem Biophys Res Commun. 1983 Oct 31;116(2):696–703. doi: 10.1016/0006-291x(83)90581-8. [DOI] [PubMed] [Google Scholar]
  18. Harris P. J., Thomas D., Morgan T. O. Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption. Nature. 1987 Apr 16;326(6114):697–698. doi: 10.1038/326697a0. [DOI] [PubMed] [Google Scholar]
  19. Hintze T. H., Currie M. G., Needleman P. Atriopeptins: renal-specific vasodilators in conscious dogs. Am J Physiol. 1985 Apr;248(4 Pt 2):H587–H591. doi: 10.1152/ajpheart.1985.248.4.H587. [DOI] [PubMed] [Google Scholar]
  20. Hirata Y., Ishii M., Sugimoto T., Matsuoka H., Ishimitsu T., Atarashi K., Sugimoto T., Miyata A., Kangawa K., Matsuo H. Relationship between the renin-aldosterone system and atrial natriuretic polypeptide in rats. Clin Sci (Lond) 1987 Feb;72(2):165–170. doi: 10.1042/cs0720165. [DOI] [PubMed] [Google Scholar]
  21. Holtz J., Stewart D. J., Elsner D., Bassenge E. In vivo atrial peptide-venodilation: minimal potency relative to nitroglycerin in dogs. Life Sci. 1986 Dec 8;39(23):2177–2184. doi: 10.1016/0024-3205(86)90394-2. [DOI] [PubMed] [Google Scholar]
  22. Lang R. E., Unger T., Ganten D. Atrial natriuretic peptide: a new factor in blood pressure control. J Hypertens. 1987 Jun;5(3):255–271. doi: 10.1097/00004872-198706000-00001. [DOI] [PubMed] [Google Scholar]
  23. Lappe R. W., Smits J. F., Todt J. A., Debets J. J., Wendt R. L. Failure of atriopeptin II to cause arterial vasodilation in the conscious rat. Circ Res. 1985 Apr;56(4):606–612. doi: 10.1161/01.res.56.4.606. [DOI] [PubMed] [Google Scholar]
  24. Marks E. S., Zukowska-Grojec Z., Ropchak T., Keiser H. R. Alterations in systemic haemodynamics induced by atriopeptin III. J Hypertens. 1987 Feb;5(1):39–46. doi: 10.1097/00004872-198702000-00006. [DOI] [PubMed] [Google Scholar]
  25. Murad F. Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest. 1986 Jul;78(1):1–5. doi: 10.1172/JCI112536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Needleman P., Greenwald J. E. Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med. 1986 Mar 27;314(13):828–834. doi: 10.1056/NEJM198603273141306. [DOI] [PubMed] [Google Scholar]
  27. Pegram B. L., Trippodo N. C., Natsume T., Kardon M. B., Frohlich E. D., Cole F. E., MacPhee A. A. Hemodynamic effects of atrial natriuretic hormone. Fed Proc. 1986 Aug;45(9):2382–2386. [PubMed] [Google Scholar]
  28. Richards A. M., Cleland J. G., Tonolo G., McIntyre G. D., Leckie B. J., Dargie H. J., Ball S. G., Robertson J. I. Plasma alpha natriuretic peptide in cardiac impairment. Br Med J (Clin Res Ed) 1986 Aug 16;293(6544):409–412. doi: 10.1136/bmj.293.6544.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Richards A. M., Nicholls M. G., Ikram H., Webster M. W., Yandle T. G., Espiner E. A. Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers. Lancet. 1985 Mar 9;1(8428):545–549. doi: 10.1016/s0140-6736(85)91207-3. [DOI] [PubMed] [Google Scholar]
  30. Richards A. M., Tonolo G., McIntyre G. D., Leckie B. J., Robertson J. I. Radio-immunoassay for plasma alpha human atrial natriuretic peptide: a comparison of direct and pre-extracted methods. J Hypertens. 1987 Apr;5(2):227–236. doi: 10.1097/00004872-198704000-00015. [DOI] [PubMed] [Google Scholar]
  31. Robinson B. F. Assessment of the effect of drugs on the venous system in man. Br J Clin Pharmacol. 1978 Nov;6(5):381–386. doi: 10.1111/j.1365-2125.1978.tb04600.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Robinson B. F., Collier J. G. Vascular smooth muscle. Correlations between basic properties and responses of human blood-vessels. Br Med Bull. 1979 Sep;35(3):305–312. doi: 10.1093/oxfordjournals.bmb.a071593. [DOI] [PubMed] [Google Scholar]
  33. Tikkanen I., Fyhrquist F., Metsärinne K., Leidenius R. Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers. Lancet. 1985 Jul 13;2(8446):66–69. doi: 10.1016/s0140-6736(85)90178-3. [DOI] [PubMed] [Google Scholar]
  34. Webb D. J., Collier J. G. Influence of ramipril diacid on the peripheral vascular effects of angiotensin I. Am J Cardiol. 1987 Apr 24;59(10):45D–49D. doi: 10.1016/0002-9149(87)90052-x. [DOI] [PubMed] [Google Scholar]
  35. Winquist R. J., Faison E. P., Nutt R. F. Vasodilator profile of synthetic atrial natriuretic factor. Eur J Pharmacol. 1984 Jun 15;102(1):169–173. doi: 10.1016/0014-2999(84)90353-4. [DOI] [PubMed] [Google Scholar]
  36. Xiang J. Z., Linz W., Becker H., Ganten D., Lang R. E., Schölkens B., Unger T. Effects of converting enzyme inhibitors: ramipril and enalapril on peptide action and sympathetic neurotransmission in the isolated heart. Eur J Pharmacol. 1985 Jul 17;113(2):215–223. doi: 10.1016/0014-2999(85)90738-1. [DOI] [PubMed] [Google Scholar]
  37. Zimmerman B. G. Adrenergic facilitation by angiotensin: does it serve a physiological function? Clin Sci (Lond) 1981 Apr;60(4):343–348. doi: 10.1042/cs0600343. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES