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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1988 Dec;26(6):797–799. doi: 10.1111/j.1365-2125.1988.tb05322.x

Venous responsiveness to atrial natriuretic factor in man.

G A Ford 1, H G Eichler 1, B B Hoffman 1, T F Blaschke 1
PMCID: PMC1386598  PMID: 2977285

Abstract

The venorelaxant effect of atrial natriuretic factor in man was studied using the dorsal hand vein technique. Infusion of met-ANF to preconstricted veins at doses up to 240 ng min-1 in 11 healthy male subjects caused only minimal venorelaxation. Atrial natriuretic factor is unlikely to have a significant venorelaxant effect at physiological doses in man.

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Selected References

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  1. Aellig W. H. A new technique for recording compliance of human hand veins. Br J Clin Pharmacol. 1981 Mar;11(3):237–243. doi: 10.1111/j.1365-2125.1981.tb00527.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eichler H. G., Hiremath A., Katzir D., Blaschke T. F., Hoffman B. B. Absence of age-related changes in venous responsiveness to nitroglycerin in vivo in humans. Clin Pharmacol Ther. 1987 Nov;42(5):521–524. doi: 10.1038/clpt.1987.191. [DOI] [PubMed] [Google Scholar]
  3. Faison E. P., Siegl P. K., Morgan G., Winquist R. J. Regional vasorelaxant selectivity of atrial natriuretic factor in isolated rabbit vessels. Life Sci. 1985 Sep 16;37(11):1073–1079. doi: 10.1016/0024-3205(85)90599-5. [DOI] [PubMed] [Google Scholar]
  4. Hughes A., Thom S., Goldberg P., Martin G., Sever P. Direct effect of alpha-human atrial natriuretic peptide on human vasculature in vivo and in vitro. Clin Sci (Lond) 1988 Feb;74(2):207–211. doi: 10.1042/cs0740207. [DOI] [PubMed] [Google Scholar]
  5. Needleman P., Greenwald J. E. Atriopeptin: a cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med. 1986 Mar 27;314(13):828–834. doi: 10.1056/NEJM198603273141306. [DOI] [PubMed] [Google Scholar]
  6. Pan H. Y., Hoffman B. B., Pershe R. A., Blaschke T. F. Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man. J Pharmacol Exp Ther. 1986 Dec;239(3):802–807. [PubMed] [Google Scholar]
  7. Richards A. M., Nicholls M. G., Ikram H., Webster M. W., Yandle T. G., Espiner E. A. Renal, haemodynamic, and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers. Lancet. 1985 Mar 9;1(8428):545–549. doi: 10.1016/s0140-6736(85)91207-3. [DOI] [PubMed] [Google Scholar]
  8. Watkins R. W., Sybertz E. J., Tedesco R. P. Nitroprusside, but not ANF inhibits venoconstriction in an in situ rat model. Eur J Pharmacol. 1987 Nov 17;143(3):299–304. doi: 10.1016/0014-2999(87)90453-5. [DOI] [PubMed] [Google Scholar]
  9. Winquist R. J. The relaxant effects of atrial natriuretic factor on vascular smooth muscle. Life Sci. 1985 Sep 23;37(12):1081–1087. doi: 10.1016/0024-3205(85)90351-0. [DOI] [PubMed] [Google Scholar]

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