Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1968 Sep;168(3):502–521. doi: 10.1097/00000658-196809000-00016

Identification of the diarrheogenic hormone associated with non-beta islet cell tumors of the pancreas.

R M Zollinger, R K Tompkins, J R Amerson, G L Endahl, A R Kraft, F T Moore
PMCID: PMC1387358  PMID: 4300128

Full text

PDF
506

Images in this article

508Fig. 1A.
on p.508
509Fig. 1B.
on p.509
512Fig. 2.
on p.512
513Fig. 3.
on p.513
515Fig. 4.
on p.515
516Fig. 5.
on p.516
516Fig. 6.
on p.516

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bank S., Marks I. N., Sealy R., Louw J. H., Silber W. Malignant Zollinger-Ellison syndrome in a Bantu woman with a prolonged remission after gastric radiotherapy. Gut. 1965 Jun;6(3):279–285. doi: 10.1136/gut.6.3.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bodanszky M., Ondetti M. A., Levine S. D., Narayanan V. L., Von Saltza M., Sheehan J. T., Williams N. J., Sabo E. F. Synthesis of a heptacosapeptide amide with the hormonal activity of sccretin. Chem Ind. 1966 Oct 15;42:1757–1758. [PubMed] [Google Scholar]
  3. CARAWAY W. T. A stable starch substrate for the determination of amylase in serum and other body fluids. Am J Clin Pathol. 1959 Jul;32(1):97–99. doi: 10.1093/ajcp/32.1_ts.97. [DOI] [PubMed] [Google Scholar]
  4. GREENLEE H. B., LONGHI E. H., GUERRERO J. D., NELSEN T. S., EL-BEDRI A. L., DRAGSTEDT L. R. Inhibitory effect of pancreatic secretin on gastric secretion. Am J Physiol. 1957 Sep;190(3):396–402. doi: 10.1152/ajplegacy.1957.190.3.396. [DOI] [PubMed] [Google Scholar]
  5. GREGORY R. A., TRACY H. J., FRENCH J. M., SIRCUS W. Extraction of a gastrin-like substance from a pancreatic tumour in a case of Zollinger-Ellison syndrome. Lancet. 1960 May 14;1(7133):1045–1048. doi: 10.1016/s0140-6736(60)90932-6. [DOI] [PubMed] [Google Scholar]
  6. Gardner J. D., Cerda J. J. In vitro inhibition of intestinal fluid and electrolyte transfer by a non-beta islet cell tumor. Proc Soc Exp Biol Med. 1966 Nov;123(2):361–364. doi: 10.3181/00379727-123-31488. [DOI] [PubMed] [Google Scholar]
  7. Gardner J. D., Peskin G. W., Cerda J. J., Brooks F. P. Alterations of in vitro fluid and electrolyte absorption by gastrointestinal hormones. Am J Surg. 1967 Jan;113(1):57–64. doi: 10.1016/0002-9610(67)90257-7. [DOI] [PubMed] [Google Scholar]
  8. Greenough W. B., 3rd Pancreatic and hepatic hypersecretion in cholera. Lancet. 1965 Nov 13;2(7420):991–994. doi: 10.1016/s0140-6736(65)92848-5. [DOI] [PubMed] [Google Scholar]
  9. Grossman M. I. Treatment of duodenal ulcer with secretin: a speculative proposal. Gastroenterology. 1966 Jun;50(6):912–913. [PubMed] [Google Scholar]
  10. Johansen P. G., Hadorn B., Anderson C. M. Effect of secretin on human rectal mucosa in vivo. Nature. 1968 Feb 3;217(5127):468–468. doi: 10.1038/217468a0. [DOI] [PubMed] [Google Scholar]
  11. Kofstad J., Froyshov I., Gjone E., Blix S. Pancreatic tumor with intractable watery diarrhea, hypokalemia and hypercalcemia electrolyte balance studies. Scand J Gastroenterol. 1967;2(4):246–250. doi: 10.3109/00365526709180076. [DOI] [PubMed] [Google Scholar]
  12. LIN T. M., ALPHIN R. S. Comparative bio-assay of secretin and pancreozymin in rats and dogs. Am J Physiol. 1962 Nov;203:926–928. doi: 10.1152/ajplegacy.1962.203.5.926. [DOI] [PubMed] [Google Scholar]
  13. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  14. MAYNARD E. P., 3rd, POINT W. W. Steatorrhea associated with ulcerogenic tumor of the pancreas. Am J Med. 1958 Sep;25(3):456–459. doi: 10.1016/0002-9343(58)90085-8. [DOI] [PubMed] [Google Scholar]
  15. MURRAY J. S., PATON R. R., POPE C. E., 2nd Pancreatic tumor associated with flushing and diarrhea. Report of a case. N Engl J Med. 1961 Mar 2;264:436–439. doi: 10.1056/NEJM196103022640905. [DOI] [PubMed] [Google Scholar]
  16. Marks I. N., Bank S., Louw J. H. Islet cell tumor of the pancreas with reversible watery diarrhea and achylorhydraia. Gastroenterology. 1967 Apr;52(4):695–708. [PubMed] [Google Scholar]
  17. McGavran M. H., Unger R. H., Recant L., Polk H. C., Kilo C., Levin M. E. A glucagon-secreting alpha-cell carcinoma of the pancreas. N Engl J Med. 1966 Jun 23;274(25):1408–1413. doi: 10.1056/NEJM196606232742503. [DOI] [PubMed] [Google Scholar]
  18. Moore F. T., Nadler H., Radefeld D. A., Zollinger R. M. Prolonged remission of diarrhea due to nonbeta islet cell tumor of the pancreas by radiotherapy. Am J Surg. 1968 Jun;115(6):854–855. doi: 10.1016/0002-9610(68)90534-5. [DOI] [PubMed] [Google Scholar]
  19. NATELSON S. Routine use of ultramicro methods in the clinical laboratory; estimation of sodium, potassium, chloride, protein, hematocrit value, sugar, urea and nonprotein nitrogen in fingertip blood; construction of ultramicro pipets; a practical microgasometer for estimation of carbon dioxide. Am J Clin Pathol. 1951 Dec;21(12):1153–1172. [PubMed] [Google Scholar]
  20. PRIEST W. M., ALEXANDER M. K. Isletcell tumour of the pancreas with peptic ulceration, diarrhoea, and hypokalaemia. Lancet. 1957 Dec 7;273(7006):1145–1147. doi: 10.1016/s0140-6736(57)92051-2. [DOI] [PubMed] [Google Scholar]
  21. SHIEBER W. INSULIN-PRODUCING ZOLLINGER-ELLISON TUMOR. Surgery. 1963 Sep;54:448–450. [PubMed] [Google Scholar]
  22. TELLING M., SMIDDY F. G. Islet tumours of the pancreas with intractable diarrhoea. Gut. 1961 Mar;2:12–17. doi: 10.1136/gut.2.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. VAN DER VEER J. S., CHOUFOER J. C., QUERIDO A., VAN DER HEUL R. O., HOLLANDER C. F., VAN RIJSSEL T. METASTASISING ISLET-CELL TUMOUR OF THE PANCREAS ASSOCIATED WITH HYPOGLYCAEMIA AND CARCINOID SYNDROME. Lancet. 1964 Jun 27;2(7348):1416–1419. doi: 10.1016/s0140-6736(64)91985-3. [DOI] [PubMed] [Google Scholar]
  24. VERNER J. V., MORRISON A. B. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med. 1958 Sep;25(3):374–380. doi: 10.1016/0002-9343(58)90075-5. [DOI] [PubMed] [Google Scholar]
  25. Wormsley K. G. Response to secretin in man. Gastroenterology. 1968 Feb;54(2):197–209. [PubMed] [Google Scholar]
  26. ZOLLINGER R. M., ELLISON E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8. [PMC free article] [PubMed] [Google Scholar]
  27. Zaterka S., Grossman M. I. The effect of gastrin and histamine on secretion of bile. Gastroenterology. 1966 Apr;50(4):500–505. [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES