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. 1966 Jul;185(2):471–485. doi: 10.1113/jphysiol.1966.sp007997

Presynaptic inhibition evoked by muscle contraction

M S Devanandan, Rosamond M Eccles, D Stenhouse
PMCID: PMC1395816  PMID: 16992233

Abstract

1. Contractions of flexor and extensor muscles of the knee and ankle were used to investigate presynaptic inhibition at the spinal level.

2. Contractions evoked dorsal root potentials, and increased the excitability of the central terminals of group Ia, Ib and low threshold cutaneous primary afferent fibres.

3. The monosynaptic reflexes recorded in response to stimulation of flexor or extensor muscle nerves were depressed, in the presence of strychnine hydrochloride 0·1 mg/kg I.V., by the contractions.

4. It is suggested that these presynaptic inhibitory effects are largely due to the activation of Golgi tendon organs by contraction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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