Abstract
1. The histamine content of the skin has been determined in untreated cats, in cats injected with the histamine liberator, compound 48/80, and in cats injected subcutaneously with an oily suspension of histamine or histidine after treatment with compound 48/80.
2. Skin histamine in cats varied from 2·2 to 37·5 μg/g. Apart from regional variations in the histamine content of the abdominal skin, lower values were obtained from cats kept on a laboratory diet which included aureomycin (mean 8·5 μg/g, range 2·2-13·1) than from cats on a high protein diet without aureomycin (mean 17·5 μg/g, range 5·2-37·5).
3. Compound 48/80 caused a depletion of skin histamine which was never complete, and a residue of 3-7% remained; in cats which originally had a low histamine content of skin, depletion was even less and up to 20% of the original histamine remained.
4. Recovery of skin histamine in cats after injections of compound 48/80 was slow, at least 110 days being required for full restoration. The rate of recovery was not altered by daily subcutaneous injections of histidine, but an effect was found with daily subcutaneous injections of histamine. Histamine had no effect for the first 33 days, but at 55 days the percentage histamine content of the skin was greater than in the cats treated with histidine or the oily suspending vehicle, and at 110 days the histamine content was not only much greater than the other two groups but was greater than that before injection of compound 48/80.
5. No in vitro histamine formation was detected in the skin samples either before compound 48/80 treatment or at any time during the subsequent recovery of the histamine to control levels.
6. The results support the theory that the histamine found in skin tissues of the cat is not formed there but is taken up from the blood stream.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- FELDBERG W., MILES A. A. Regional variations of increased permeability of skin capillaries induced by a histamine liberator and their relation to the histamine content of the skin. J Physiol. 1953 Apr 28;120(1-2):205–213. doi: 10.1113/jphysiol.1953.sp004885. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FELDBERG W., TALESNIK J. Reduction of tissue histamine by compound 48/80. J Physiol. 1953 Jun 29;120(4):550–568. doi: 10.1113/jphysiol.1953.sp004917. [DOI] [PMC free article] [PubMed] [Google Scholar]
- IRVINE W. T., DUTHIE H. L., WATON N. G. Urinary output of free histamine after a meat meal. Lancet. 1959 May 23;1(7082):1061–1064. doi: 10.1016/s0140-6736(59)90649-x. [DOI] [PubMed] [Google Scholar]
- KAHLSON G., NILSSON K., ROSENGREN E., ZEDERFELDT B. Wound healing as on rate of histamine formation. Lancet. 1960 Jul 30;2(7144):230–234. doi: 10.1016/s0140-6736(60)91426-4. [DOI] [PubMed] [Google Scholar]
- RILEY J. F., WEST G. B. Tissue mast cells: studies with a histamine-liberator of low toxicity (compound 48/80). J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):269–282. doi: 10.1002/path.1700690135. [DOI] [PubMed] [Google Scholar]
- SCHAYER R. W., ROTHSCHILD Z., BIZONY P. Increase in histidine decarboxylase activity of rat skin following treatment with compound 48/80. Am J Physiol. 1959 Feb;196(2):295–298. doi: 10.1152/ajplegacy.1959.196.2.295. [DOI] [PubMed] [Google Scholar]
- SMITH A. N. Release of histamine by the histamine liberator compound 48/80 in cats. J Physiol. 1953 Sep;121(3):517–538. doi: 10.1113/jphysiol.1953.sp004962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATON N. G. Is tissue histamine formation necessary in cat, dog and man? Int Arch Allergy Appl Immunol. 1963;22:87–101. doi: 10.1159/000229390. [DOI] [PubMed] [Google Scholar]
- WATON N. G. Studies on mammalian histidine decarboxylase. Br J Pharmacol Chemother. 1956 Jun;11(2):119–127. doi: 10.1111/j.1476-5381.1956.tb01039.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATON N. G. Urinary excretion of free histamine in guineapigs after oral histidine. J Physiol. 1963 Jan;165:174–178. doi: 10.1113/jphysiol.1963.sp007050. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WESTERHOLM B. In vitro release of histamine from cat skin by compound 48/80. Acta Physiol Scand. 1960 Sep 30;50:41–48. doi: 10.1111/j.1748-1716.1960.tb02071.x. [DOI] [PubMed] [Google Scholar]