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. 1970 Dec;211(3):539–549. doi: 10.1113/jphysiol.1970.sp009292

The relation between L-methionine uptake and sodium in rat small intestine in vitro

H Newey, A J Rampone, D H Smyth
PMCID: PMC1396080  PMID: 5501050

Abstract

1. Uptakes of L-methionine and mannitol by rat jejunum in vitro were measured over test periods from 5 to 120 sec after 30 min pre-test periods in the presence or absence of Na.

2. The initial stage in methionine uptake was dependent on the presence of Na+ and to a lesser extent on the K+ concentration. In contrast mannitol uptake was independent of Na and K.

3. The initial stage in methionine uptake can be reactivated 30-60% within 5 sec by replacing an Na-deficient intestine into an Na-containing medium.

4. Initial methionine uptake was greater with a normal intracellular and low medium Na concentration than with a high medium and low intracellular Na concentration. It is suggested that the intracellular Na concentration is a critical factor, more important than the Na gradient, in determining the rate of amino acid transfer across the luminal membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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