Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1979 Jan;189(1):62–67. doi: 10.1097/00000658-197901000-00013

Intimal thickening and hyperlipidemia in experimental primate vascular autografts.

R L McCann, R M Larson, J S Mitchener 3rd, J C Fuchs, P O Hagen
PMCID: PMC1396939  PMID: 103507

Abstract

Intimal thickening is a significant cause of late failure of aorto-coronary vein grafts. The microscopic appearance of this thickening has some similarities to the microscopic appearance of arterial atherosclerosis, and it has been suggested that hyperlipidemia may play a role in its pathogenesis. This study examines the morphology and lipid composition of autologous vein and artery grafts in normal and hyperlipidemic rhesus monkeys. Grafts were examined six months after insertion by light and electron microscopy and tissue lipids were determined quantitatively. Intimal thickening occurred in all grafts. Specific morphological and lipid compositional features of the grafts were influenced by the type of tissue used for grafting and the presence or absence of hyperlipidemia. However, the degree of intimal thickening per se could not be related to either of these two factors. It is concluded that surgical transplantation in this model provides the most powerful stimulus for intimal thickening and any additional effect on this process by hyperlipidemia is small.

Full text

PDF
62

Images in this article

64Fig. 2a.
on p.64
64Fig. 2a.
on p.64
64Fig. 2b.
on p.64
64Fig. 2b.
on p.64
65Fig. 3a and b.
on p.65

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barboriak J. J., Batayias G. E., Pintar K., Korns M. E. Pathological changes in surgically removed aortocoronary vein grafts. Ann Thorac Surg. 1976 Jun;21(6):524–527. doi: 10.1016/s0003-4975(10)63922-7. [DOI] [PubMed] [Google Scholar]
  2. Barboriak J. J., Batayias G. E., Pintar K., Tieu T. M., Van Horn D. L., Korns M. E. Late lesions in aorta-coronary artery vein grafts. J Thorac Cardiovasc Surg. 1977 Apr;73(4):596–601. [PubMed] [Google Scholar]
  3. Bond M. G., Hostetler J. R., Karayannacos P. E., Geer J. C., Vasko J. S. Intimal changes in arteriovenous bypass grafts. Effects of varying the angle of implantation at the proximal anastomosis and of producing stenosis in the distal runoff artery. J Thorac Cardiovasc Surg. 1976 Jun;71(6):907–916. [PubMed] [Google Scholar]
  4. Bulkley B. H., Hutchins G. M. Accelerated "atherosclerosis". A morphologic study of 97 saphenous vein coronary artery bypass grafts. Circulation. 1977 Jan;55(1):163–169. doi: 10.1161/01.cir.55.1.163. [DOI] [PubMed] [Google Scholar]
  5. Curtis J., Conkle D. M., Finch W. T., Lanier V. C., Jr, Younger R. K., Scott H. W., Jr The effects of experimental hypercholesterolemia on transposed arterial and venous autografts. J Surg Res. 1975 Feb;18(2):163–167. doi: 10.1016/0022-4804(75)90011-6. [DOI] [PubMed] [Google Scholar]
  6. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  7. Grondin C. M., Castonguay Y. R., Lepage G., Meere C., Grondin P. Aortocoronary bypass grafts. Early postoperative angiographic evaluation and reexploration for stenosis or thrombosis of the vein graft. Arch Surg. 1971 Nov;103(5):535–538. doi: 10.1001/archsurg.1971.01350110033004. [DOI] [PubMed] [Google Scholar]
  8. Grondin C. M., Lespérance J., Bourassa M. G., Pasternac A., Campneau L., Grondin P. Serial angiograpic evaluation in 60 consecutive patients with aorto-coronary artery vein grafts 2 weeks, 1 year, and 3 years after operation. J Thorac Cardiovasc Surg. 1974 Jan;67(1):1–6. [PubMed] [Google Scholar]
  9. Hagen P. O. Structural comparison between triglycerides and phospholipids from pig kidney. Lipids. 1971 Dec;6(12):935–941. doi: 10.1007/BF02531178. [DOI] [PubMed] [Google Scholar]
  10. Haimovici H., Maier N. Autogenous vein grafts in experimental canine atherosclerosis. Their fate in the abdominal aorta and peripheral arteries. Arch Surg. 1974 Jul;109(1):95–102. doi: 10.1001/archsurg.1974.01360010073018. [DOI] [PubMed] [Google Scholar]
  11. Kern W. H., Dermer G. B., Lindesmith G. G. The intimal proliferation in aortic-coronary saphenous vein grafts. Light and electron microscopic studies. Am Heart J. 1972 Dec;84(6):771–777. doi: 10.1016/0002-8703(72)90070-1. [DOI] [PubMed] [Google Scholar]
  12. King P., Royle J. P. Autogenous vein grafting in atheromatous rabbits. Cardiovasc Res. 1972 Nov;6(6):627–633. doi: 10.1093/cvr/6.6.627. [DOI] [PubMed] [Google Scholar]
  13. Lawrie G. M., Lie J. T., Morris G. C., Jr, Beazley H. L. Vein graft patency and intimal proliferation after aortocoronary bypass: early and long-term angiopathologic correlations. Am J Cardiol. 1976 Dec;38(7):856–862. doi: 10.1016/0002-9149(76)90798-0. [DOI] [PubMed] [Google Scholar]
  14. Ross R., Glomset J. A. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973 Jun 29;180(4093):1332–1339. doi: 10.1126/science.180.4093.1332. [DOI] [PubMed] [Google Scholar]
  15. Ross R., Harker L. Hyperlipidemia and atherosclerosis. Science. 1976 Sep 17;193(4258):1094–1100. doi: 10.1126/science.822515. [DOI] [PubMed] [Google Scholar]
  16. Rossiter S. J., Brody W. R., Kosek J. C., Lipton M. J., Angell W. W. Internal mammary artery versus autogenous vein for coronary artery bypass graft. Circulation. 1974 Dec;50(6):1236–1243. doi: 10.1161/01.cir.50.6.1236. [DOI] [PubMed] [Google Scholar]
  17. Rudel L. L., Lee J. A., Morris M. D., Felts J. M. Characterization of plasma lipoproteins separated and purified by agarose-column chromatography. Biochem J. 1974 Apr;139(1):89–95. doi: 10.1042/bj1390089. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Unni K. K., Kottke B. A., Titus J. L., Frye R. L., Wallace R. B., Brown A. L. Pathologic changes in aortocoronary saphenous vein grafts. Am J Cardiol. 1974 Oct 3;34(5):526–532. doi: 10.1016/0002-9149(74)90122-2. [DOI] [PubMed] [Google Scholar]
  19. Vlodaver Z., Edwards J. E. Pathologic analysis in fatal cases following saphenous vein coronary arterial bypass. Chest. 1973 Nov;64(5):555–563. doi: 10.1378/chest.64.5.555. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES