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. 1996;38(Suppl 2):S43–S47. doi: 10.1136/gut.38.suppl_2.s43

Epidemiology and control of hepatitis B infection: a perspective from the Philippines, Asia.

M A Lansang 1
PMCID: PMC1398043  PMID: 8786053

Abstract

The prevalence of chronic hepatitis B virus (HBV) infection in the Philippines, as indicated by hepatitis B surface antigen (HBsAg) positivity, ranges from 2% to 16.5%, with an average of 12% in a study of rural villagers. Although mother to child transmission is a major route of HBV infection, other routes (particularly child to child transmission) play an important part after the first year of life. In a study assessing the feasibility and effectiveness of incorporating hepatitis B vaccine into the national Expanded Programme on Immunisation, the coverage rate for fully immunised 1 year olds ranged from 80.9-84% and anti-HBs seroconversion rates ranged from 72-88%. In countries where HBV is not endemic, high risk groups include commercial sex workers (CSWs) and intravenous drug users (IVDUs), who generally have higher HBsAg positivity rates than the general population. In countries with a high HBV endemicity, carrier rates may be only slightly higher among CSWs, suggesting that other modes of transmission are more important in those regions. CSWs who are also IVDUs are at even greater risk. If HBV infection is to be controlled, innovative education and screening programmes are needed, together with the mass immunisation of neonates now started in many countries around the world.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson B., Bodsworth N. J., Rohrsheim R. A., Donovan B. J. Hepatitis B virus infection and vaccination status of high risk people in Sydney: 1982 and 1991. Med J Aust. 1994 Sep 19;161(6):368–371. doi: 10.5694/j.1326-5377.1994.tb127489.x. [DOI] [PubMed] [Google Scholar]
  2. Basaca-Sevilla V., Cross J. H., Pastrana E. The hepatitis B problem in the Philippines. Southeast Asian J Trop Med Public Health. 1986 Mar;17(1):75–81. [PubMed] [Google Scholar]
  3. Bratòs M. A., Eiros J. M., Orduña A., Cuervo M., Ortiz de Lejarazu R., Almaraz A., Martín-Rodríguez J. F., Gutiérrez-Rodríguez M. P., Orduña Prieto E., Rodríguez-Torres A. Influence of syphilis in hepatitis B transmission in a cohort of female prostitutes. Sex Transm Dis. 1993 Sep-Oct;20(5):257–261. doi: 10.1097/00007435-199309000-00003. [DOI] [PubMed] [Google Scholar]
  4. Chen C. J., Hwang S. J., Fan K. Y., Chang S. A., Chang Y. H., Wang S. R., Liu W. T., Liaw Y. F., Chai C. Y., Chang R. Seroepidemiology of human T lymphotropic viruses and hepatitis viruses among prostitutes in Taiwan. J Infect Dis. 1988 Sep;158(3):633–635. doi: 10.1093/infdis/158.3.633. [DOI] [PubMed] [Google Scholar]
  5. Christopher P. J., Crewe E. B., Mailer P. T., Murphy A. M. Hepatitis B infection among STD clinic patients in Sydney. Aust N Z J Med. 1984 Aug;14(4):491–494. doi: 10.1111/j.1445-5994.1984.tb03624.x. [DOI] [PubMed] [Google Scholar]
  6. Coppola R. C., Manconi P. E., Piro R., Di Martino M. L., Masia G. HCV, HIV, HBV and HDV infections in intravenous drug addicts. Eur J Epidemiol. 1994 Jun;10(3):279–283. doi: 10.1007/BF01719350. [DOI] [PubMed] [Google Scholar]
  7. Elifson K. W., Boles J., Sweat M. Risk factors associated with HIV infection among male prostitutes. Am J Public Health. 1993 Jan;83(1):79–83. doi: 10.2105/ajph.83.1.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gan C. Y., Yap S. F., Ngeow Y. F., Wong H. C. Hepatitis B infection among Chinese STD patients in Kuala Lumpur, Malaysia. Sex Transm Dis. 1991 Apr-Jun;18(2):84–88. doi: 10.1097/00007435-199118020-00006. [DOI] [PubMed] [Google Scholar]
  9. Goh C. L., Kamarudin A., Chan S. H., Rajan V. S. Hepatitis B virus markers in prostitutes in Singapore. Genitourin Med. 1985 Apr;61(2):127–129. doi: 10.1136/sti.61.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Goh C. L., Rajan V. S., Chan S. H., Kamarudin A. Hepatitis B infection in prostitutes. Int J Epidemiol. 1986 Mar;15(1):112–115. doi: 10.1093/ije/15.1.112. [DOI] [PubMed] [Google Scholar]
  11. Hyams K. C., Escamilla J., Lozada Romero R., Macareno Alvarado E., Bonilla Giraldo N., Papadimos T. J., Rubio Martinez C., Garcia Gonzalez P. Hepatitis B infection in a non-drug abusing prostitute population in Mexico. Scand J Infect Dis. 1990;22(5):527–531. doi: 10.3109/00365549009027091. [DOI] [PubMed] [Google Scholar]
  12. Hyams K. C., Phillips I. A., Tejada A., Li O., Hermoza P., Lopez F., Alva P., Chauca G., Sanchez S., Wignall F. S. Hepatitis B in a highly active prostitute population: evidence for a low risk of chronic antigenemia. J Infect Dis. 1990 Aug;162(2):295–298. doi: 10.1093/infdis/162.2.295. [DOI] [PubMed] [Google Scholar]
  13. Lingao A. L., Domingo E. O., Nishioka K. Hepatitis B virus profile of hepatocellular carcinoma in the Philippines. Cancer. 1981 Oct 1;48(7):1590–1595. doi: 10.1002/1097-0142(19811001)48:7<1590::aid-cncr2820480720>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  14. Lingao A. L., Domingo E. O., West S., Reyes C. M., Gasmen S., Viterbo G., Tiu E., Lansang M. A. Seroepidemiology of hepatitis B virus in the Philippines. Am J Epidemiol. 1986 Mar;123(3):473–480. doi: 10.1093/oxfordjournals.aje.a114262. [DOI] [PubMed] [Google Scholar]
  15. Maayan S., Shufman E. N., Engelhard D., Shouval D. Exposure to hepatitis B and C and to HTLV-1 and 2 among Israeli drug abusers in Jerusalem. Addiction. 1994 Jul;89(7):869–874. doi: 10.1111/j.1360-0443.1994.tb00990.x. [DOI] [PubMed] [Google Scholar]
  16. Nakashima K., Kashiwagi S., Noguchi A., Hayashi J., Morofuji M., Yamauchi Y., Tokiyama K. [An epidemiological study of HBV and HTLV-I among high risk groups in Fukuoka City]. Kansenshogaku Zasshi. 1990 Apr;64(4):419–424. doi: 10.11150/kansenshogakuzasshi1970.64.419. [DOI] [PubMed] [Google Scholar]
  17. Orduña A., Bratos M. A., Gutierrez P., Almaraz A., Eiros J. M., Martín J. F., Gonzalez J. M., Caro-Patón A., Rodríguez-Torres A. Infection by hepatitis B and C virus in non-intravenous drug using female prostitutes in Spain. Eur J Epidemiol. 1992 Sep;8(5):656–659. doi: 10.1007/BF00145380. [DOI] [PubMed] [Google Scholar]
  18. Pollock J. J., Andors L., Gulumoglu A., Ells P. F. Direct measurement of hepatitis B viral antibody and antigen markers in gingival crevicular fluid. Oral Surg Oral Med Oral Pathol. 1984 May;57(5):499–503. doi: 10.1016/0030-4220(84)90307-4. [DOI] [PubMed] [Google Scholar]
  19. Rosenblum L., Darrow W., Witte J., Cohen J., French J., Gill P. S., Potterat J., Sikes K., Reich R., Hadler S. Sexual practices in the transmission of hepatitis B virus and prevalence of hepatitis delta virus infection in female prostitutes in the United States. JAMA. 1992 May 13;267(18):2477–2481. [PubMed] [Google Scholar]
  20. Struve J., Käll K., Stendahl P., Scalia-Tomba G., Giesecke J., Weiland O. Prevalence of hepatitis B virus markers among intravenous drug abusers in Stockholm: impact of heterosexual transmission. Scand J Infect Dis. 1993;25(1):8–13. [PubMed] [Google Scholar]
  21. Sy N. E., Basaca-Sevilla V., Esguerra T., Beasley R. P., Hwang L. Y., Cross J. H. HBsAG and HBeAG markers among pregnant women in Manila, Philippines. Trans R Soc Trop Med Hyg. 1986;80(5):767–770. doi: 10.1016/0035-9203(86)90381-0. [DOI] [PubMed] [Google Scholar]
  22. Tabet S. R., Palmer D. L., Wiese W. H., Voorhees R. E., Pathak D. R. Seroprevalence of HIV-1 and hepatitis B and C in prostitutes in Albuquerque, New Mexico. Am J Public Health. 1992 Aug;82(8):1151–1154. doi: 10.2105/ajph.82.8.1151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Torrella Ramos A., Hernández Aguado I., Santos Rubio C., Fernández García E., García de la Hera M., Aviñ Rico M. J. Determinantes de la prevalencia de infección por virus B de la hepatitis en usuarios de drogas por vía parenteral. Rev Clin Esp. 1993 Dec;193(9):475–479. [PubMed] [Google Scholar]
  24. Van Ameijden E. J., Van den Hoek J. A., Mientjes G. H., Coutinho R. A. A longitudinal study on the incidence and transmission patterns of HIV, HBV and HCV infection among drug users in Amsterdam. Eur J Epidemiol. 1993 May;9(3):255–262. doi: 10.1007/BF00146260. [DOI] [PubMed] [Google Scholar]
  25. Wang E. E., King S., Goldberg E., Bock B., Milner R., Read S. Hepatitis B and human immunodeficiency virus infection in street youths in Toronto, Canada. Pediatr Infect Dis J. 1991 Feb;10(2):130–133. doi: 10.1097/00006454-199102000-00011. [DOI] [PubMed] [Google Scholar]
  26. Wu Q., Li Z., Fan J. [A seroepidemiological study on sexually transmitted HBV infection]. Zhonghua Liu Xing Bing Xue Za Zhi. 1994 Apr;15(2):67–70. [PubMed] [Google Scholar]
  27. Zeldis J. B., Jain S., Kuramoto I. K., Richards C., Sazama K., Samuels S., Holland P. V., Flynn N. Seroepidemiology of viral infections among intravenous drug users in northern California. West J Med. 1992 Jan;156(1):30–35. [PMC free article] [PubMed] [Google Scholar]

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