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. 1986 Apr;21(4):425–429. doi: 10.1111/j.1365-2125.1986.tb05217.x

Prolonged midazolam elimination half-life.

J W Dundee, P S Collier, R J Carlisle, K W Harper
PMCID: PMC1400931  PMID: 2939863

Abstract

The pharmacokinetics of a fixed dose of midazolam (0.3 mg kg-1 i.v.) were studied in detail in 115 healthy patients or volunteers and nine were found with a prolonged elimination half-life. A further 102 patients had an abbreviated pharmacokinetic study, of whom five showed a similar abnormality. Defective hepatic metabolism of midazolam may be a factor in the aetiology of what appears to be a true phenomenon, occurring in 6% of over 200 fit subjects given a standard dose of the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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