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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1986 Jul;22(1):93–96.

In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

S Fu, A Björkman, B Wåhlin, D Ofori-Adjei, O Ericsson, F Sjöqvist
PMCID: PMC1401091  PMID: 3527245

Abstract

A 48 h in vitro test was conducted to compare the susceptibility of two strains of Plasmodium falciparum to chloroquine, the two enantiomers of chloroquine, desethylchloroquine and the new antimalarial drug pyronaridine. The five compounds similarly inhibited the chloroquine sensitive strain. However, desethylchloroquine was less active and pyronaridine was much more active than chloroquine and its enantiomers against the chloroquine resistant strain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aderounmu A. F. In vitro assessment of the antimalarial activity of chloroquine and its major metabolites. Ann Trop Med Parasitol. 1984 Dec;78(6):581–585. doi: 10.1080/00034983.1984.11811868. [DOI] [PubMed] [Google Scholar]
  2. Bruce-Chwatt L. J. Chemoprophylaxis of malaria in Africa: the spent "magic bullet". Br Med J (Clin Res Ed) 1982 Sep 11;285(6343):674–676. doi: 10.1136/bmj.285.6343.674. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fink E., Minet G., Nickel P. Chloroquin-Enantiomere. Wirkung gegen Nagetiermalaria (P. vinckei) und Bindung an DNS. Arzneimittelforschung. 1979;29(1):163–164. [PubMed] [Google Scholar]
  4. Gustafsson L. L., Walker O., Alván G., Beermann B., Estevez F., Gleisner L., Lindström B., Sjöqvist F. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol. 1983 Apr;15(4):471–479. doi: 10.1111/j.1365-2125.1983.tb01532.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Haberkorn A., Kraft H. P., Blaschke G. Antimalarial activity of the optical isomers of chloroquine diphosphate. Tropenmed Parasitol. 1979 Sep;30(3):308–312. [PubMed] [Google Scholar]
  6. Lapierre J. Paludisme à Plasmodium falciparum, polychimioresistant, traité avec succès par la benzonaphthyridine. Nouv Presse Med. 1982 Feb 27;11(9):673–673. [PubMed] [Google Scholar]
  7. Nguyen-Dinh P., Trager W. Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test. Am J Trop Med Hyg. 1980 May;29(3):339–342. doi: 10.4269/ajtmh.1980.29.339. [DOI] [PubMed] [Google Scholar]
  8. Ni Y. C., Zhan C. Q., HA S. H., Shao B. R. [The embryotoxicity of a new antimalarial pyronaridine in rats]. Yao Xue Xue Bao. 1982 Jun;17(6):401–406. [PubMed] [Google Scholar]
  9. Trager W., Jensen J. B. Human malaria parasites in continuous culture. Science. 1976 Aug 20;193(4254):673–675. doi: 10.1126/science.781840. [DOI] [PubMed] [Google Scholar]
  10. Verdier F., Le Bras J., Clavier F., Hatin I. Blood levels and in vitro activity of desethylchloroquine against Plasmodium falciparum. Lancet. 1984 May 26;1(8387):1186–1187. doi: 10.1016/s0140-6736(84)91436-3. [DOI] [PubMed] [Google Scholar]
  11. Wåhlin B., Wahlgren M., Perlmann H., Berzins K., Björkman A., Patarroyo M. E., Perlmann P. Human antibodies to a Mr 155,000 Plasmodium falciparum antigen efficiently inhibit merozoite invasion. Proc Natl Acad Sci U S A. 1984 Dec;81(24):7912–7916. doi: 10.1073/pnas.81.24.7912. [DOI] [PMC free article] [PubMed] [Google Scholar]

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