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. 1986 Jul;22(1):55–59. doi: 10.1111/j.1365-2125.1986.tb02880.x

Renal failure does not impair the metabolism of morphine.

D F Woolner, D Winter, T J Frendin, E J Begg, K L Lynn, G J Wright
PMCID: PMC1401094  PMID: 3741727

Abstract

The pharmacokinetics of morphine were measured using gas chromatography-mass spectrometry (GCMS) with specific ion monitoring after the intramuscular administration of papaveretum to four patients with renal failure (one anephric) and three normals. The apparent t1/2 of absorption and t1/2 of elimination were significantly shorter in the patients with renal failure (P less than 0.05). Morphine glucuronides are eliminated slowly in these patients as expected. Renal failure does not impair the elimination of morphine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ball M., McQuay H. J., Moore R. A., Allen M. C., Fisher A., Sear J. Renal failure and the use of morphine in intensive care. Lancet. 1985 Apr 6;1(8432):784–786. doi: 10.1016/s0140-6736(85)91448-5. [DOI] [PubMed] [Google Scholar]
  2. Ebbighausen W. O., Mowat J. H., Stearns H., Vestergaard P. Mass fragmentography of morphine and 6-monoacetylmorphine in blood with a stable isotope internal standard. Biomed Mass Spectrom. 1974 Oct;1(5):305–311. doi: 10.1002/bms.1200010503. [DOI] [PubMed] [Google Scholar]
  3. Grabinski P. Y., Kaiko R. F., Walsh T. D., Foley K. M., Houde R. W. Morphine radioimmunoassay specificity before and after extraction of plasma and cerebrospinal fluid. J Pharm Sci. 1983 Jan;72(1):27–30. doi: 10.1002/jps.2600720107. [DOI] [PubMed] [Google Scholar]
  4. Hanks G. W., Aherne G. W. Morphine metabolism: does the renal hypothesis hold water? Lancet. 1985 Jan 26;1(8422):221–222. doi: 10.1016/s0140-6736(85)92057-4. [DOI] [PubMed] [Google Scholar]
  5. Ikram H., Lynn K. L., Bailey R. R., Little P. J. Cardiovascular changes in chronic hemodialysis patients. Kidney Int. 1983 Sep;24(3):371–376. doi: 10.1038/ki.1983.169. [DOI] [PubMed] [Google Scholar]
  6. Joel S. P., Osborne R. J., Nixon N. S., Slevin M. L. Morphine-6-glucuronide, an important metabolite. Lancet. 1985 May 11;1(8437):1099–1100. doi: 10.1016/s0140-6736(85)92397-9. [DOI] [PubMed] [Google Scholar]
  7. Lee H. K., Gnad P. A., Trebilco P. R., Wright G. J., Pannell L. K. A multiple-scan high resolution mass spectrometer data system for the analysis of mixtures: the analysis of morphine in liver. Biomed Mass Spectrom. 1980 Oct;7(10):418–423. doi: 10.1002/bms.1200071003. [DOI] [PubMed] [Google Scholar]
  8. McQuay H., Moore A. Be aware of renal function when prescribing morphine. Lancet. 1984 Aug 4;2(8397):284–285. doi: 10.1016/s0140-6736(84)90323-4. [DOI] [PubMed] [Google Scholar]
  9. Moore A., Sear J., Baldwin D., Allen M., Hunniset A., Bullingham R., McQuay H. Morphine kinetics during and after renal transplantation. Clin Pharmacol Ther. 1984 May;35(5):641–645. doi: 10.1038/clpt.1984.88. [DOI] [PubMed] [Google Scholar]
  10. Moore R. A., Baldwin D., Allen M. C., Watson P. J., Bullingham R. E., McQuay H. J. Sensitive and specific morphine radioimmunoassay with iodine label: pharmacokinetics of morphine in man after intravenous administration. Ann Clin Biochem. 1984 Jul;21(Pt 4):318–325. doi: 10.1177/000456328402100415. [DOI] [PubMed] [Google Scholar]
  11. Stanski D. R., Greenblatt D. J., Lowenstein E. Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther. 1978 Jul;24(1):52–59. doi: 10.1002/cpt197824152. [DOI] [PubMed] [Google Scholar]
  12. Säwe J., Svensson J. O., Odar-Cederlöf I. Kinetics of morphine in patients with renal failure. Lancet. 1985 Jul 27;2(8448):211–211. doi: 10.1016/s0140-6736(85)91520-x. [DOI] [PubMed] [Google Scholar]
  13. Yeh S. Y. Urinary excretion of morphine and its metabolites in morphine-dependent subjects. J Pharmacol Exp Ther. 1975 Jan;192(1):201–210. [PubMed] [Google Scholar]

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