Skip to main content
PMC home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1986 Oct;22(4):409–413. doi: 10.1111/j.1365-2125.1986.tb02910.x

Effect of captopril on changes in plasma noradrenaline induced by sodium nitroprusside.

R H Becker, A D Struthers, M J Brown
PMCID: PMC1401165  PMID: 3533124

Abstract

There is much animal data to suggest that angiotensin II has a regulatory role in noradrenaline release. We sought evidence for such a mechanism in man by pretreating six normal volunteers with captopril (50 mg) or placebo and then infusing them with incremental doses of sodium nitroprusside. Pretreatment with captopril had no significant effect on the mean arterial pressure, heart rate or plasma noradrenaline response to sodium nitroprusside, despite increasing plasma renin activity. This suggests that in normotensive salt replete man, normal levels of angiotensin II do not exert any tonic effect on noradrenaline release.

Full text

PDF
412

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Antonaccio M. J., Kerwin L. Evidence for prejunctional inhibition of norepinephrine release by captopril in spontaneously hypertensive rats. Eur J Pharmacol. 1980 Nov 21;68(2):209–212. doi: 10.1016/0014-2999(80)90325-8. [DOI] [PubMed] [Google Scholar]
  2. Brown M. J., Jenner D. A. Novel double-isotope technique for enzymatic assay of catecholamines, permitting high precision, sensitivity and plasma sample capacity. Clin Sci (Lond) 1981 Nov;61(5):591–598. doi: 10.1042/cs0610591. [DOI] [PubMed] [Google Scholar]
  3. Campbell B. C., Sturani A., Reid J. L. Evidence of parasympathetic activity of the angiotensin converting enzyme inhibitor, captopril, in normotensive man. Clin Sci (Lond) 1985 Jan;68(1):49–56. doi: 10.1042/cs0680049. [DOI] [PubMed] [Google Scholar]
  4. Dean C. R., Maling T., Dargie H. J., Reid J. L., Dollery C. T. Effect of propranolol on plasma norepinephrine during sodium nitroprusside-induced hypotension. Clin Pharmacol Ther. 1980 Feb;27(2):156–164. doi: 10.1038/clpt.1980.24. [DOI] [PubMed] [Google Scholar]
  5. Giudicelli J. F., Berdeaux A., Edouard A., Richer C., Jacolot D. The effect of enalapril on baroreceptor mediated reflex function in normotensive subjects. Br J Clin Pharmacol. 1985 Sep;20(3):211–218. doi: 10.1111/j.1365-2125.1985.tb05063.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hatton R., Clough D. P. Captopril interferes with neurogenic vasoconstriction in the pithed rat by angiotensin-dependent mechanisms. J Cardiovasc Pharmacol. 1982 Jan-Feb;4(1):116–123. doi: 10.1097/00005344-198201000-00019. [DOI] [PubMed] [Google Scholar]
  7. Imai Y., Abe K., Seino M., Haruyama T., Tajima J., Yoshinaga K., Sekino H. Captopril attenuates pressor responses to norepinephrine and vasopressin through depletion of endogenous angiotensin II. Am J Cardiol. 1982 Apr 21;49(6):1537–1539. doi: 10.1016/0002-9149(82)90381-2. [DOI] [PubMed] [Google Scholar]
  8. Inokuchi K., Malik K. U. Inhibition by bradykinin of renal adrenergic effects in anesthetized rats. Am J Physiol. 1984 Apr;246(4 Pt 2):F387–F394. doi: 10.1152/ajprenal.1984.246.4.F387. [DOI] [PubMed] [Google Scholar]
  9. Millar J. A., Derkx F. H., McLean K., Reid J. L. Pharmacodynamics of converting enzyme inhibition: the cardiovascular, endocrine and autonomic effects of MK421 (enalapril) and MK521. Br J Clin Pharmacol. 1982 Sep;14(3):347–355. doi: 10.1111/j.1365-2125.1982.tb01990.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Millar J. A., McGrath B. P., Matthews P. G., Johnston C. I. Acute effects of captopril on blood pressure and circulating hormone levels in salt-replete and depleted normal subjects and essential hypertensive patients. Clin Sci (Lond) 1981 Jul;61(1):75–83. doi: 10.1042/cs0610075. [DOI] [PubMed] [Google Scholar]
  11. Murphy M. B., Scriven A. J., Brown M. J., Causon R., Dollery C. T. The effects of nifedipine and hydralazine induced hypotension on sympathetic activity. Eur J Clin Pharmacol. 1982;23(6):479–482. doi: 10.1007/BF00637492. [DOI] [PubMed] [Google Scholar]
  12. Wenting G. J., Man in't veld A. J., Woittiez A. J., Boomsma F., Laird-Meeter K., Simoons M. L., Hugenholtz P. G., Schalekamp M. A. Effects of captopril in acute and chronic heart failure. Correlations with plasma levels of noradrenaline, renin, and aldosterone. Br Heart J. 1983 Jan;49(1):65–76. doi: 10.1136/hrt.49.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Zimmerman B. G. Adrenergic facilitation by angiotensin: does it serve a physiological function? Clin Sci (Lond) 1981 Apr;60(4):343–348. doi: 10.1042/cs0600343. [DOI] [PubMed] [Google Scholar]
  14. Zimmerman B. G., Gomer S. K., Liao J. C. Action of angiotensin on vascular adrenergic nerve endings: facilitation of norepinephrine release. Fed Proc. 1972 Jul-Aug;31(4):1344–1350. [PubMed] [Google Scholar]
  15. Zimmerman B. G., Sybertz E. J., Wong P. C. Interaction between sympathetic and renin-angiotensin system. J Hypertens. 1984 Dec;2(6):581–587. doi: 10.1097/00004872-198412000-00002. [DOI] [PubMed] [Google Scholar]
  16. de Jonge A., Knape J. T., van Meel J. C., Kalkman H. O., Wilffert B., Thoolen M. J., Timmermanns P. B., van Zwieten P. A. Effect of converting enzyme inhibition and angiotensin receptor blockade on the vasoconstriction mediated by alpha 1-and alpha 2-adrenoceptor stimulation in pithed normotensive rats. Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):309–313. doi: 10.1007/BF00498519. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES