Abstract
Antipyrine clearance was measured before and 1 day after administration of a single intramuscular dose of recombinant human leukocyte alpha A interferon. In the nine patients studied, antipyrine clearance was reduced after interferon from 0.49 (0.21-1.13) ml kg-1 min-1 (median (range)) to 0.41 (0.20-1.07) ml kg-1 min-1, P less than 0.01. In individual patients, the decrement in antipyrine clearance was variable, ranging from 5-47% (median, 16%). This study provides the first direct evidence that interferon inhibits hepatic oxidative drug metabolism in humans and alerts clinicians to the possibility of potentially toxic drug-drug interactions.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Farrell G. C., Zaluzny L. Accuracy and clinical utility of simplified tests of antipyrine metabolism. Br J Clin Pharmacol. 1984 Oct;18(4):559–565. doi: 10.1111/j.1365-2125.1984.tb02504.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gray J. D., Renton K. W., Hung O. R. Depression of theophylline elimination following BCG vaccination. Br J Clin Pharmacol. 1983 Dec;16(6):735–737. doi: 10.1111/j.1365-2125.1983.tb02253.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutterman J. U., Blumenschein G. R., Alexanian R., Yap H. Y., Buzdar A. U., Cabanillas F., Hortobagyi G. N., Hersh E. M., Rasmussen S. L., Harmon M. Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma. Ann Intern Med. 1980 Sep;93(3):399–406. doi: 10.7326/0003-4819-93-3-399. [DOI] [PubMed] [Google Scholar]
- Meredith C. G., Christian C. D., Johnson R. F., Troxell R., Davis G. L., Schenker S. Effects of influenza virus vaccine on hepatic drug metabolism. Clin Pharmacol Ther. 1985 Apr;37(4):396–401. doi: 10.1038/clpt.1985.61. [DOI] [PubMed] [Google Scholar]
- Omata M., Imazeki F., Yokosuka O., Ito Y., Uchiumi K., Mori J., Okuda K. Recombinant leukocyte a interferon treatment in patients with chronic hepatitis B virus infection. Pharmacokinetics, tolerance, and biologic effects. Gastroenterology. 1985 Apr;88(4):870–880. doi: 10.1016/s0016-5085(85)80002-0. [DOI] [PubMed] [Google Scholar]
- Quesada J. R., Reuben J., Manning J. T., Hersh E. M., Gutterman J. U. Alpha interferon for induction of remission in hairy-cell leukemia. N Engl J Med. 1984 Jan 5;310(1):15–18. doi: 10.1056/NEJM198401053100104. [DOI] [PubMed] [Google Scholar]
- Renton K. W., Singh G., Stebbing N. Relationship between the antiviral effects of interferons and their abilities to depress cytochrome P-450. Biochem Pharmacol. 1984 Dec 1;33(23):3899–3902. doi: 10.1016/0006-2952(84)90058-3. [DOI] [PubMed] [Google Scholar]
- Roberts R. K., Grice J., Wood L., Petroff V., McGuffie C. Cimetidine impairs the elimination of theophylline and antipyrine. Gastroenterology. 1981 Jul;81(1):19–21. [PubMed] [Google Scholar]
- Singh G., Renton K. W. Inhibition of the synthesis of hepatic cytochrome P-450 by the interferon-inducing agent poly rI.rCi. Can J Physiol Pharmacol. 1984 Apr;62(4):379–383. doi: 10.1139/y84-060. [DOI] [PubMed] [Google Scholar]
- Taylor G., Marafino B. J., Jr, Moore J. A., Gurley V., Blaschke T. F. Interferon reduces hepatic drug metabolism in vivo in mice. Drug Metab Dispos. 1985 Jul-Aug;13(4):459–463. [PubMed] [Google Scholar]
- Vesell E. S. The antipyrine test in clinical pharmacology: conceptions and misconceptions. Clin Pharmacol Ther. 1979 Sep;26(3):275–286. doi: 10.1002/cpt1979263275. [DOI] [PubMed] [Google Scholar]
- el Azhary R., Renton K. W., Mannering G. J. Effect of interferon inducing agents (polyriboinosinic acid . polyribocytidylic acid and tilorone) on the heme turnover of hepatic cytochrome P-450. Mol Pharmacol. 1980 May;17(3):395–399. [PubMed] [Google Scholar]