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. 1974 Aug;1(4):301–306. doi: 10.1111/j.1365-2125.1974.tb00257.x

A pilot study of orally administered Δ1-trans-tetrahydrocannabinol in the management of patients undergoing radiotherapy for carcinoma of the bronchus

B H Davies, R M Weatherstone, J D P Graham, R D Griffiths
PMCID: PMC1402430  PMID: 22454883

Abstract

1 Δ1-trans-tetrahydrocannabinol (Δ1-THC; 10 mg) or a placebo was given orally on 7 days to two groups of six patients on a cross-over pattern with 7 days rest between.

2 The patients were hospitalized, suffering from inoperable bronchogenic carcinoma, subjected to radiation therapy, and anxious.

3 Self-rating mood scales were filled in before, and 2 and 6 h after ingestion on the first and seventh day of medication.

4 Records of sleep, pain, general well-being, temperature, cardiovascular and gastrointestinal parameters were kept.

5 Δ1-THC caused drowsiness and improved night sleep, reduced pain, increased fatigue and confusion and reduced elation and vigour; it caused slight tachycardia and hypotension as also did placebo.

6 The effects of Δ1-THC were stronger after 2 h than 6 h and no tolerance had developed at 7 days.

7 The management of stressful patients was considered to have been improved by the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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