Abstract
1 The half-life of hydrocortisone (cortisol) has been measured in six patients before and after a three-week course of prednisone given for asthma.
2 There was considerable variation in peak plasma level of cortisol both within and between patients, but on both occasions the plasma half-lives were the same.
3 It was concluded that short courses of prednisone have no effect on the handling of hydrocortisone.
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Selected References
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- Collins J. V., Clark T. J., Harris P. W., Townsend J. Intravenous corticosteroids in treatment of acute bronchial asthma. Lancet. 1970 Nov 21;2(7682):1047–1049. doi: 10.1016/s0140-6736(70)90283-7. [DOI] [PubMed] [Google Scholar]
- Dwyer J., Lazarus L., Hickie J. B. A study of cortisol metabolism in patients with chronic asthma. Australas Ann Med. 1967 Nov;16(4):297–304. doi: 10.1111/imj.1967.16.4.297. [DOI] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwartz H. J., Lowell F. C., Melby J. C. Steroid resistance in bronchial asthma. Ann Intern Med. 1968 Sep;69(3):493–499. doi: 10.7326/0003-4819-69-3-493. [DOI] [PubMed] [Google Scholar]
- Speizer F. E., Doll R., Heaf P., Strang L. B. Investigation into use of drugs preceding death from asthma. Br Med J. 1968 Feb 10;1(5588):339–343. doi: 10.1136/bmj.1.5588.339. [DOI] [PMC free article] [PubMed] [Google Scholar]