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Journal of the Experimental Analysis of Behavior logoLink to Journal of the Experimental Analysis of Behavior
. 1962 Jan;5(1):105–112. doi: 10.1901/jeab.1962.5-105

Effects of dl-amphetamine under concurrent VI DRL reinforcement

Evalyn F Segal
PMCID: PMC1404169  PMID: 16811266

Abstract

Three adult, food-deprived rats were given IP injections of dl-amphetamine sulfate under DRL and concurrent VI DRL reinforcement schedules. The drug results were as follows.

(1) The IRT distributions of DRL responses shifted to the left, but some temporal discrimination remained. (2) The IRT distributions of VI responses shifted slightly to the left. (3) The distinguishing characteristics of VI and DRL IRT distributions were preserved. (4) The frequency distribution of number of VI responses between two consecutive DRL responses was relatively unaffected. (5) Over-all response rates on the two components of the concurrent schedules increased more or less proportionately.

These findings imply that the primary behavioral effect of dl-amphetamine was a motor excitatory one. The drug's disruption of timing behavior was not due to a derangement of internal timing mechanisms, nor to interference with the topography or pattern of behavior. Rather, it might be a secondary result of the accelerated emission of overt behavior patterns mediating the temporal spacing of DRL bar presses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANGER D. The dependence of interresponse times upon the relative reinforcement of different interresponse times. J Exp Psychol. 1956 Sep;52(3):145–161. doi: 10.1037/h0041255. [DOI] [PubMed] [Google Scholar]
  2. BRADY J. V. A review of comparative behavioral pharmacology. Ann N Y Acad Sci. 1957 Mar 14;66(3):719–732. doi: 10.1111/j.1749-6632.1957.tb40761.x. [DOI] [PubMed] [Google Scholar]
  3. BRADY J. V., CONRAD D. G. Some effects of brain stimulation on timing behavior. J Exp Anal Behav. 1960 Apr;3:93–106. doi: 10.1901/jeab.1960.3-93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DEWS P. B. Free-operant behavior under conditions of delayed reinforcement. I. CRF-type schedules. J Exp Anal Behav. 1960 Jul;3:221–234. doi: 10.1901/jeab.1960.3-221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DEWS P. B. Studies on behavior. II. The effects of pentobarbital, methamphetamine and scopolamine on performances in pigeons involving discriminations. J Pharmacol Exp Ther. 1955 Dec;115(4):380–389. [PubMed] [Google Scholar]
  6. DEWS P. B. Studies on behavior. IV. Stimulant actions of methamphetamine. J Pharmacol Exp Ther. 1958 Jan;122(1):137–147. [PubMed] [Google Scholar]
  7. Dews P. B., Morse W. H. Some observations on an operant in human subjects and its modification by dextro amphetamine. J Exp Anal Behav. 1958 Oct;1(4):359–364. doi: 10.1901/jeab.1958.1-359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HERRNSTEIN R. J., MORSE W. H. Effects of drugs on characteristics of behavior maintained by complex schedules of intermittent positive reinforcement. Ann N Y Acad Sci. 1956 Nov 2;65(4):303–317. doi: 10.1111/j.1749-6632.1956.tb49641.x. [DOI] [PubMed] [Google Scholar]
  9. MILLENSON J. R., HURWITZ H. M. Some temporal and sequential properties of behavior during conditioning and extinction. J Exp Anal Behav. 1961 Apr;4:97–106. doi: 10.1901/jeab.1961.4-97. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MILLER N. E. Effects of drugs on motivation; the value of using a variety of measures. Ann N Y Acad Sci. 1956 Nov 2;65(4):318–333. doi: 10.1111/j.1749-6632.1956.tb49642.x. [DOI] [PubMed] [Google Scholar]
  11. MILLER N. E. Experiments on motivation. Studies combining psychological, physiological, and pharmacological techniques. Science. 1957 Dec 20;126(3286):1271–1278. doi: 10.1126/science.126.3286.1271. [DOI] [PubMed] [Google Scholar]
  12. NOTTERMAN J. M. Force emission during bar pressing. J Exp Psychol. 1959 Nov;58:341–347. doi: 10.1037/h0042801. [DOI] [PubMed] [Google Scholar]
  13. OWEN J. E., Jr The influence of dl-, d-, and l-amphetamine and d-methamphetamine on a fixed-ratio schedule. J Exp Anal Behav. 1960 Oct;3:293–310. doi: 10.1901/jeab.1960.3-293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. PREMACK D. Predicting instrumental performance from the independent rate of the contingent response. J Exp Psychol. 1961 Feb;61:163–171. doi: 10.1037/h0042090. [DOI] [PubMed] [Google Scholar]
  15. PREMACK D. Toward empirical behavior laws. I. positive reinforcement. Psychol Rev. 1959 Jul;66(4):219–233. doi: 10.1037/h0040891. [DOI] [PubMed] [Google Scholar]
  16. SEGAL E. F. Behavioral interaction under concurrent spaced-responding, variable-interval schedules of reinforcement. J Exp Anal Behav. 1961 Jul;4:263–266. doi: 10.1901/jeab.1961.4-263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SEGAL E. F. Confirmation of a positive relation between deprivation and number of responses emitted for light reinforcement. J Exp Anal Behav. 1959 Apr;2:165–169. doi: 10.1901/jeab.1959.2-165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SIDMAN M. Behavioral pharmacology. Psychopharmacologia. 1959;1:1–19. doi: 10.1007/BF00408107. [DOI] [PubMed] [Google Scholar]
  19. SIDMAN M. Drug-behavior interaction. Ann N Y Acad Sci. 1956 Nov 2;65(4):282–302. doi: 10.1111/j.1749-6632.1956.tb49640.x. [DOI] [PubMed] [Google Scholar]
  20. SIDMAN M. Technique for assessing the effects of drugs on timing behavior. Science. 1955 Nov 11;122(3176):925–925. doi: 10.1126/science.122.3176.925. [DOI] [PubMed] [Google Scholar]
  21. SIDMAN M. Time discrimination and behavioral interaction in a free operant situation. J Comp Physiol Psychol. 1956 Oct;49(5):469–473. doi: 10.1037/h0041892. [DOI] [PubMed] [Google Scholar]
  22. TEITELBAUM P., DERKS P. The effect of amphetamine on forced drinking in the rat. J Comp Physiol Psychol. 1958 Dec;51(6):801–810. doi: 10.1037/h0038460. [DOI] [PubMed] [Google Scholar]
  23. Verhave T. The effect of methamphetamine on operant level and avoidance behavior. J Exp Anal Behav. 1958 Aug;1(3):207–219. doi: 10.1901/jeab.1958.1-207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. WEISSMAN A. Differential drug effects upon a three-ply multiple schedule of reinforcement. J Exp Anal Behav. 1959 Oct;2:271–287. doi: 10.1901/jeab.1959.2-271. [DOI] [PMC free article] [PubMed] [Google Scholar]

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